Protein detail
GTR1
Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
Protein symbol GTR1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 12 | Protein classification Cancer-related genesDisease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
Transmembrane
12..33; Helical; Name=1; 67..87; Helical; Name=2; 91..112; Helical; Name=3; 121..144; Helical; Name=4; 156..176; Helical; Name=5; 186..206; Helical; Name=6; 272..293; Helical; Name=7; 307..328; Helical; Name=8; 335..355; Helical; Name=9; 366..388; Helical; Name=10; 402..422; Helical; Name=11; 430..450; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
CSEDYT18DYT9GLUTGLUT-1GLUT1HTLVR
Gene Description
Solute carrier family 2 member 1
Chromosome
1
Position
42925353-42958893
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
Cellular Component
- GO:0000139 Golgi membrane
- GO:0001674 female germ cell nucleus
- GO:0001917 photoreceptor inner segment
- GO:0001939 female pronucleus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0014704 intercalated disc
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030018 Z disc
- GO:0030496 midbody
- GO:0030864 cortical actin cytoskeleton
- GO:0042383 sarcolemma
- GO:0042470 melanosome
- GO:0070062 extracellular exosome
- GO:0072562 blood microparticle
- GO:0098793 presynapse
- GO:1990350 glucose transporter complex
Molecular Function
- GO:0005324 long-chain fatty acid transmembrane transporter activity
- GO:0005515 protein binding
- GO:0019900 kinase binding
- GO:0033300 dehydroascorbic acid transmembrane transporter activity
- GO:0042802 identical protein binding
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0055056 D-glucose transmembrane transporter activity
Biological Process
KEGG
- hsa04066 HIF-1 signaling pathway
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa04920 Adipocytokine signaling pathway
- KEGG:hsa04922 Glucagon signaling pathway
- KEGG:hsa04931 Insulin resistance
- KEGG:hsa04976 Bile secretion
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05211 Renal cell carcinoma
- KEGG:hsa05230 Central carbon metabolism in cancer
- KEGG:hsa05415 Diabetic cardiomyopathy
Reactome
- R-hsa-189200 cellular hexose transport
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-163685 integration of energy metabolism
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-422356 regulation of insulin secretion
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-5619102 slc transporter disorders
- R-hsa-382551 transport of small molecules
- R-hsa-196836 vitamin c ascorbate metabolism
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLC2A1 | ATM | Q13315 | S | 490 | phosphorylation | REACH_ProtMapperPhosphoSiteProtMapper | ProtMapper:30799198 |
| SLC2A1 | AGT | P01019 | S | 226 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:30087656 |
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STOM | P27105 | GTR1 | P11166 | Yes | No | Yes | HPRDMPPISIGNOR | MPPI:10562431HPRD:10562431SIGNOR:10562431 |
| ATM | Q13315 | GTR1 | P11166 | Yes | No | No | ProtMapperSPIKE_LCREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SPIKE_LC:17525332ProtMapper:30799198PhosphoSite:30799198 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Glucose transporter complex 1 | SLC2A1 | P11166 | 1 | ComplexPortal | intact:EBI-959455 | 15449578147552921429721 |
| NPC1PDE6DSLC25A15SLC2A14UBCUBE2NL | O15118O43924P0CG48Q5JXB2Q8TDB8Q9Y619 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4175 | ||
| NPC1SLC25A15SLC2A14TMEM33UBCUBE2NL | O15118P0CG48P57088Q5JXB2Q8TDB8Q9Y619 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6603 | ||
| MND1NPC1SLC25A15SLC2A14UBCUBE2NL | O15118P0CG48Q5JXB2Q8TDB8Q9BWT6Q9Y619 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7473 | ||
| ORMDL3SLC2A12SPRY4 | Q8N138Q8TD20Q9C004 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture | Mass spectrometryWestern blotting|Immunoelectron MicroscopyWestern blottingR Sequencing | 18 | 377869183228482539766158363985643778691838168906372050983481790628986585216304622789410429045505383215353955813439569406400890671983798234980157 |
Sequence, Structure & Domains
Sequences
Length
492
Mass
54,084
Sequence
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
3D Structural Models
Turn
150..152; 177..180; 183..185; 216..218; 284..286; 357..360; 382..385; 397..399
Helix
11..31; 37..52; 58..81; 83..90; 92..111; 113..116; 119..147; 153..157; 159..173; 186..191; 194..203; 204..206; 211..215; 221..231; 238..252; 259..264; 266..283; 287..300; 306..327; 328..330; 333..356; 364..381; 386..394; 400..429; 430..432; 433..450
Beta Strand
32..34
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Region
468..492; Disordered
Protein Families
- Major facilitator superfamily
- Sugar transporter (TC 2.A.1.1) family
- Glucose transporter subfamily
Sequence Similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesCataractDisease variantDystoniaEpilepsyHereditary hemolytic anemiaIntellectual disability
Related Diseases
Biomarker
Preclinical
Drugs
Interaction Protein
ENSG00000071553ENSG00000082898ENSG00000096384ENSG00000111737ENSG00000155561ENSG00000185344
Interaction Count
6
Interaction Dataset
biogrid_bioplexbiogrid_opencell