Protein detail
EPB41
Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)
Protein symbol EPB41 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
4.1REL1
Gene Description
Erythrocyte membrane protein band 4.1
Chromosome
1
Position
28887091-29120046
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificCholangiocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificnaive CD8 T-cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0005938 cell cortex
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0014731 spectrin-associated cytoskeleton
- GO:0016323 basolateral plasma membrane
- GO:0016604 nuclear body
- GO:0030054 cell junction
- GO:0030863 cortical cytoskeleton
- GO:0032991 protein-containing complex
- GO:0045171 intercellular bridge
- GO:0072686 mitotic spindle
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
15 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EPB41 | EGFR | P00533 | Y | 660 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapper | dbPTM:1647028dbPTM:2171679SIGNOR:1647028phosphoELM:1647028KEA:1647028ProtMapper:1647028 |
| EPB41 | EGFR | P00533 | Y | 437 | phosphorylation | HPRDKEA | KEA:1647028HPRD:1647028 |
| EPB41 | EGFR | P00533 | Y | 418 | phosphorylation | HPRDPhosphoSiteKEA | KEA:1647028HPRD:1647028 |
| EPB41 | CDK1 | P06493 | S | 712 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperdbPTMREACH_ProtMapper | dbPTM:18220336dbPTM:15525677dbPTM:2171679ProtMapper:15525677dbPTM:18669648 |
| EPB41 | CDK1 | P06493 | T | 60 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPProtMapperdbPTMREACH_ProtMapperPhosphoSite | dbPTM:2171679dbPTM:15525677ProtMapper:15525677 |
| EPB41 | CDK1 | P06493 | S | 679 | phosphorylation | PhosphoSite | |
| EPB41 | PRKCB | P05771 | S | 312 | phosphorylation | HPRDPhosphoSiteKEA | HPRD:15611095KEA:15611095 |
| EPB41 | PRKCB | P05771 | S | 521 | phosphorylation | MIMPHPRD_MIMPPhosphoSite_MIMP | |
| EPB41 | PRKCB | P05771 | S | 578 | phosphorylation | MIMPHPRD_MIMPKEAPhosphoSite_MIMP | KEA:15611095 |
| EPB41 | PRKCB | P05771 | S | 369 | phosphorylation | KEA | KEA:15611095 |
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Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ferm_domain | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EGFR | P00533 | EPB41 | P11171 | Yes | Yes | Yes | HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDCui2007CA1WangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos | HPRD-phos:1647028dbPTM:1647028PhosphoSite:1647028dbPTM:2171679HPRD:1647028SIGNOR:1647028phosphoELM:1647028KEA:1647028CA1:1647028ProtMapper:1647028 |
| EPB41 | P11171 | DLG1 | Q12959 | Yes | Yes | No | SIGNORHPRDCui2007CA1Wang | SIGNOR:12807908CA1:7937897HPRD:7937897 |
| EPB41 | P11171 | NUMA1 | Q14980 | Yes | Yes | No | HPRDHINTLit-BM-17SIGNOR | HINT:35271311HINT:10189366SIGNOR:23870127Lit-BM-17:10189366HPRD:10189366 |
| KPCA | P17252 | EPB41 | P11171 | Yes | No | No | PhosphoSite | PhosphoSite:21542582PhosphoSite:2171679 |
| CDK1 | P06493 | EPB41 | P11171 | Yes | No | No | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperdbPTMREACH_ProtMapperPhosphoSite | dbPTM:18220336dbPTM:15525677dbPTM:2171679PhosphoSite:15525677ProtMapper:15525677dbPTM:18669648 |
Protein Complex Composition
16 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DVL3EPB41L4AFOXK1FOXK2NXN | P85037Q01167Q6DKJ4Q92997Q9HCS5 | 0:0:0:0:0 | hu.MAP2 | |||
| DVL3EPB41L4AFOXK2 | Q01167Q92997Q9HCS5 | 0:0:0 | hu.MAP2 | |||
| BLTP3ACHD9EPB41L5 | Q3L8U1Q6BDS2Q9HCM4 | 0:0:0 | hu.MAP2 | |||
| BLTP3ACHD9EPB41L5HECTD1 | Q3L8U1Q6BDS2Q9HCM4Q9ULT8 | 0:0:0:0 | hu.MAP2 | |||
| BLTP3AEPB41L5HECTD1 | Q6BDS2Q9HCM4Q9ULT8 | 0:0:0 | hu.MAP2 | |||
| EPB41L3KRT222 | Q8N1A0Q9Y2J2 | 0:0 | hu.MAP2 |
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Sequence, Structure & Domains
Sequences
Length
864
Mass
97,017
Sequence
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P11171-1; Sequence=Displayed; Name=2; IsoId=P11171-2; Sequence=VSP_000470; Name=3; IsoId=P11171-3; Sequence=VSP_000468, VSP_000471; Name=4; Synonyms=Erythroid; IsoId=P11171-4; Sequence=VSP_000468, VSP_000470, VSP_000473; Name=5; Synonyms=Non-erythroid A; IsoId=P11171-5; Sequence=VSP_000469, VSP_000470, VSP_000472; Name=6; Synonyms=Non-erythroid B; IsoId=P11171-6; Sequence=VSP_000468, VSP_000469, VSP_000470, VSP_000472; Name=7; IsoId=P11171-7; Sequence=VSP_000471, VSP_012872, VSP_012873
Alternative Sequence
1..209; Missing (in isoform 3, isoform 4 and isoform 6); 228..262; Missing (in isoform 5 and isoform 6); 616..648; Missing (in isoform 2, isoform 4, isoform 5 and isoform 6); 635..648; Missing (in isoform 3 and isoform 7); 649..669; Missing (in isoform 5 and isoform 6); 729..734; PPLVKT -> VSTLST (in isoform 7); 735..864; Missing (in isoform 7); 772..805; Missing (in isoform 4)
3D Structural Models
Turn
275..277; 394..397
Helix
232..243; 248..250; 271..274; 293..295; 299..314; 322..337; 342..345; 350..352; 361..372; 379..390; 434..436; 470..486
Beta Strand
211..215; 221..225; 251..258; 261..264; 281..288; 356..358; 399..404; 410..415; 417..424; 427..433; 437..443; 446..451; 454..458; 461..466
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1..16; Polar residues; 27..41; Polar residues; 61..75; Basic and acidic residues; 76..87; Low complexity; 101..117; Basic and acidic residues; 149..158; Polar residues; 182..199; Basic and acidic residues; 587..600; Basic and acidic residues; 601..610; Acidic residues
Domain (FT)
210..491; FERM
Region
1..122; Disordered; 136..170; Disordered; 182..202; Disordered; 494..614; Hydrophilic; 518..572; Disordered; 586..611; Disordered; 615..713; Spectrin--actin-binding; 714..864; C-terminal (CTD)
Clinical Relevance
Disease Involvement
ElliptocytosisHereditary hemolytic anemiaPyropoikilocytosis
Interaction Protein
ENSG00000170027
Interaction Count
1
Interaction Dataset
intact_biogrid