Protein detail
ITAM
Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
Protein symbol ITAM | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
Protein Class
Cancer-related genesCD markersDisease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Transmembrane
1105..1128; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD11BCR3AMAC-1
Gene Description
Integrin subunit alpha M
Chromosome
16
Position
31259967-31332892
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Cellular Component
- GO:0005615 extracellular space
- GO:0005886 plasma membrane
- GO:0008305 integrin complex
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0034688 integrin alphaM-beta2 complex
- GO:0035579 specific granule membrane
- GO:0044853 plasma membrane raft
- GO:0070062 extracellular exosome
- GO:0070821 tertiary granule membrane
Molecular Function
Biological Process
KEGG
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04145 Phagosome
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04610 Complement and coagulation cascades
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05133 Pertussis
- KEGG:hsa05134 Legionellosis
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05202 Transcriptional misregulation in cancer
- KEGG:hsa05221 Acute myeloid leukemia
Reactome
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
- R-hsa-216083 integrin cell surface interactions
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-6798695 neutrophil degranulation
- R-hsa-449147 signaling by interleukins
- R-hsa-168898 toll like receptor cascades
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| integrins | receptor | HPMR | No | Yes | No | Yes | No |
| itam | receptor | HPMR | No | Yes | No | Yes | No |
| integrin | receptor | Surfaceome | No | Yes | No | Yes | No |
| innate_immune | receptor | ICELLNET | No | Yes | No | Yes | No |
| innate_immune_complement | receptor | ICELLNET | No | Yes | No | Yes | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | No | Yes | No |
| ecm_interaction | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ITAM | P11215 | ICAM1 | P05362 | Yes | Yes | No | HPRDWangSIGNOR | HPRD:11073102SIGNOR:23994464HPRD:9488691 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| C3CFHCFIITGAM | P01024P05156P08603P11215 | 1:1:1:1 | CompleatCFinder | Compleat:HC5771 | ||
| C3ITGAM | P01024P11215 | 4:2 | PDB | PDB:4m76PDB:7akk | ||
| ITGAM | P11215 | 2 | PDB | PDB:1idnPDB:3q3gPDB:8ce9PDB:1bhoPDB:1bhqPDB:3qa3 | ||
| ITGAMPTN | P11215P21246 | 1:1 | PDB | PDB:8vohPDB:8voi | ||
| ITGAMJAM3 | P11215Q9BX67 | 0:0 | Cellinker |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | R SequencingMass spectrometry | 11 | 3228482537786918395057563481790628986585278941042904550530646616309501853832153533709510 |
Sequence, Structure & Domains
Sequences
Length
1,152
Mass
127,179
Sequence
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11215-1; Sequence=Displayed; Name=2; IsoId=P11215-2; Sequence=VSP_047365
Alternative Sequence
499; G -> GQ (in isoform 2)
3D Structural Models
Turn
32..35; 42..44; 68..70; 97..100; 237..239; 559..561; 681..683; 692..694; 743..746; 911..913; 1076..1078
Helix
163..180; 202..207; 211..215; 227..236; 241..243; 268..270; 272..277; 289..291; 294..303; 308..311; 318..324; 325..333; 371..374; 397..399; 426..428; 545..548; 573..575; 633..636; 1010..1016; 1086..1088; 1130..1132; 1133..1143
Beta Strand
25..28; 36..41; 45..50; 54..56; 61..67; 73..75; 91..96; 101..112; 117..126; 128..131; 135..140; 149..156; 159..161; 185..200; 249..259; 280..288; 312..317; 348..350; 355..359; 361..367; 378..385; 387..390; 406..413; 416..423; 430..438; 441..449; 459..464; 469..471; 474..483; 485..495; 507..509; 515..520; 524..528; 530..534; 537..542; 550..555; 568..572; 585..591; 593..597; 600..605; 608..614; 617..631; 640..642; 645..647; 650..659; 672..680; 684..686; 695..705; 710..717; 729..739; 759..764; 770..773; 780..785; 792..794; 798..800; 803..808; 813..815; 817..822; 826..832; 845..848; 860..871; 875..885; 894..902; 914..924; 928..931; 938..940; 949..958; 965..979; 981..992; 997..1003; 1019..1021; 1024..1037; 1042..1051; 1060..1062; 1064..1073; 1089..1098; 1147..1149
3D Structure
Electron microscopy (2); NMR spectroscopy (4); X-ray crystallography (19)
Domain & Motif Annotations
Repeat
18..75; FG-GAP 1; 76..135; FG-GAP 2; 339..390; FG-GAP 3; 391..442; FG-GAP 4; 443..503; FG-GAP 5; 506..564; FG-GAP 6; 569..629; FG-GAP 7
Motif
1131..1135; GFFKR motif
Domain (CC)
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Domain (FT)
150..328; VWFA
Protein Families
Integrin alpha chain family
Sequence Similarities
Belongs to the integrin alpha chain family.
Clinical Relevance
Disease Involvement
Cancer-related genesSystemic lupus erythematosus
Related Diseases
Biomarker
Phase 1/2
Drug Targets
Literature-reported target
Drugs