EV MemProt Atlas

Basic Information

Protein Names

Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)

Protein Class

Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Enzymes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000186716

Entrez Gene Symbol

BCR

Gene Synonym

ALLBCR1CMLD22S11D22S662PHL

Gene Description

BCR activator of RhoGEF and GTPase

Chromosome

22

Position

23179704-23318037

Frequency

1

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificretinaCell SpecificCone photoreceptor cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Enzymes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M68 Pid rhoa reg pathway

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

35 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
BCR	GSK3B	P49841	S	463	phosphorylation	KEA	KEA:17570479
BCR	INSR	P06213	Y	246	phosphorylation	KEA	KEA:17570479
BCR	MAPK14	Q16539	S	459	phosphorylation	KEA	KEA:17570479
BCR	PRKCA	P17252	S	1,264	phosphorylation	KEA	KEA:17570479
BCR	PRKCA	P17252	T	310	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	No	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Regulatory Interaction Network

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
BCR	P11274	ABL1	P00519	Yes	Yes	No	PhosphoPointHPRDHINTSignaLink3BioGRIDWang	HINT:1712671 SignaLink3:8112292 HINT:21653319 BioGRID:12543778 HINT:8112292 HPRD:11780146 SignaLink3:1712671 SignaLink3:23331499 BioGRID:1712671 SignaLink3:12543778
BCR	P11274	1433T	P27348	Yes	Yes	No	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAKinexus_KEAHPRD_KEASIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	HPRD-phos:19415658 HPRD-phos:18669648 HPRD-phos:9360956 ProtMapper:19415658 KEA:17081983 HPRD-phos:20068231 KEA:18669648 KEA:16045749 KEA:98030561 KEA:9360956 ProtMapper:18691976 SIGNOR:16045749 HPRD:16045749 ProtMapper:9360956 HPRD-phos:18691976 ProtMapper:20068231 ProtMapper:16045749 ProtMapper:18669648 ProtMapper:19664995 HPRD-phos:19664995
LNX1	Q8TBB1	BCR	P11274	Yes	No	Yes	SIGNOR	SIGNOR:22889411
BCR	P11274	PPARG	P37231	Yes	No	Yes	SIGNORSparser_ProtMapperProtMapper	SIGNOR:19023129 ProtMapper:19023129
BCR	P11274	RAC1	P63000	Yes	No	Yes	WangSIGNOR	SIGNOR:32203420
FES	P07332	BCR	P11274	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperSparser_ProtMapperHPRD-phos	ProtMapper:9178913 KEA:10405761 HPRD-phos:12522270 KEA:8622703 KEA:7529874 HPRD-phos:8955135 iPTMnet:9407116 phosphoELM:8955135 KEA:9178913 dbPTM:15302586 ProtMapper:12522270 HPRD:8955135 KEA:9407116 ProtMapper:15302586 HPRD:7529874 KEA:12124177 KEA:12522270 KEA:8955135 ProtMapper:16497976 SIGNOR:8955135 phosphoELM:10405761 HPRD-phos:9407116 ProtMapper:9407116 HPRD-phos:16497976 ProtMapper:8955135 ProtMapper:10405761 HPRD-phos:9178913
PTN1	P18031	BCR	P11274	Yes	No	Yes	SIGNORHPRDHINTIntActSPIKE_LCHPRD-phos	HPRD:9566916 HPRD-phos:9566916 SPIKE_LC:9566916 IntAct:9566916 SIGNOR:9566916 HINT:9566916 HINT:36086954
BCR	P11274	1433Z	P63104	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTKEAKinexus_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper	HPRD:7939633 HINT:35271311 HPRD:16045749 ProtMapper:16045749 SIGNOR:16045749 HINT:36931259 KEA:9360956
	A9UF07	BCR	P11274	Yes	No	No	iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:12124177 PhosphoSite:8955135 PhosphoSite:8112292 PhosphoSite:9178913 PhosphoSite:9747873 iPTMnet:8112292 PhosphoSite:9407116 PhosphoSite:9467953 PhosphoSite:8622703 PhosphoSite:11376433

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BCR	P11274	8	PDB	PDB:5oc7PDB:1k1f
BCR ERCC3 ERCC5	P11274 P19447 P28715	0:0:0	hu.MAP2
BCR GRAP MAPK6 NEB SOS1	P11274 P20929 Q07889 Q13588 Q16659	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8774

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	ELISA	2	26775013 40098346

Sequence, Structure & Domains

Sequences

Length

1,271

Mass

142,819

Sequence

MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11274-1; Sequence=Displayed; Name=2; IsoId=P11274-2; Sequence=VSP_024352

Alternative Sequence

961..1004; Missing (in isoform 2)

3D Structural Models

Turn

547..549

Helix

4..14; 28..64; 492..521; 524..531; 540..546; 550..569; 578..586; 588..611; 613..618; 639..651; 653..661; 670..687; 759..761; 851..865; 876..885

Beta Strand

533..535; 630..634; 694..697; 709..719; 722..740; 751..758; 762..767; 830..838; 843..847; 1268..1271

3D Structure

NMR spectroscopy (2); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

87..105; Low complexity; 123..138; Low complexity; 185..198; Basic and acidic residues; 199..208; Polar residues; 346..356; Low complexity; 369..382; Low complexity; 441..451; Basic and acidic residues

Coiled Coil

28..55

Domain (CC)

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.; DOMAIN: The DH domain is involved in interaction with CCPG1..; DOMAIN: The amino terminus contains an intrinsic kinase activity. The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The C-terminus is a Rho-GAP domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. The protein has a unique structure having two opposing regulatory activities toward small GTP-binding proteins.

Domain (FT)

498..691; DH; 708..866; PH; 893..1020; C2; 1054..1248; Rho-GAP

Region

1..426; Kinase; 67..173; Disordered; 185..247; Disordered; 197..385; Binding to ABL SH2-domain; 286..392; Disordered; 416..476; Disordered

Clinical Relevance

Disease Involvement

Cancer-related genesFDA approved drug targetsProto-oncogene

Drug Targets

FDA approved drug targetsPatented-recorded targetLiterature-reported targetSuccessful target

Antibody

CAB010421 CAB018545 HPA038337

Interaction Protein

ENSG00000108953ENSG00000141510ENSG00000164924ENSG00000204435

Interaction Count

4

Interaction Dataset

biogrid_opencellintact_biogrid

Entry name BCR	UniProt ID P11274	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteins