Protein detail

FGFR1

Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)

Entry name FGFR1	UniProt ID P11362	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters

Basic Information

Protein Names

Protein Class (11)

Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters

Protein Function (14)

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Human disease related genes:Cancers:Cancers of the breast and female genital organs
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport

Page 1 of 2

Transmembrane

377..397; Helical

Transmembrane Count

Ensembl

ENSG00000077782

Entrez Gene Symbol

FGFR1

Gene Synonym (11)

BFGFRCD331CEKFLGFLT2H2H3H4H5KAL2N-SAM

Gene Description

Fibroblast growth factor receptor 1

Chromosome

Position

38400215-38468834

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Function & Pathway

Protein Function (14)

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Human disease related genes:Cancers:Cancers of the breast and female genital organs
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport

Page 1 of 2

Cellular Component (9)

Molecular Function (10)

KEGG (18)

Page 1 of 2

Reactome (34)

Page 1 of 4

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence127

Enzyme-Mediated Modification (23)

23 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FGFR1	PRKCE	Q02156	S	779	phosphorylation	SIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:23564461 ProtMapper:23564461
FGFR1	PRKCE	Q02156	S	810	phosphorylation	MIMPPhosphoSite_MIMP
FGFR1	MAPK14	Q16539	S	777	phosphorylation	Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:18411303 ProtMapper:20626350 ProtMapper:18411303 SIGNOR:20626350
FGFR1	MAPK14	Q16539	S	808	phosphorylation	MIMPPhosphoSite_MIMP
FGFR1	MAPK3	P27361	S	777	phosphorylation	Sparser_ProtMapperSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:27342992 ProtMapper:23405013 SIGNOR:23405013
FGFR1	MAPK3	P27361	S	808	phosphorylation	MIMPPhosphoSite_MIMP
FGFR1	MAPK1	P28482	S	777	phosphorylation	Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:27342992 ProtMapper:23405013 SIGNOR:23405013
FGFR1	MAPK1	P28482	S	808	phosphorylation	MIMPPhosphoSite_MIMP
FGFR1	MMP2	P08253	V	366	cleavage	HPRD	HPRD:8692946
FGFR1	MMP2	P08253	V	279	cleavage	HPRD	HPRD:8692946

Page 1 of 3Next

Ligand-Receptor Signaling (68)

68 records.

Category	Parent	Database	Receiver	Plasma Membrane (Transmembrane)
receptor	receptor	CellCellInteractions	Yes	Yes
receptor	receptor	EMBRACE	Yes	Yes
tyrosine_kinase	receptor	HGNC	Yes	Yes
receptor	receptor	HGNC	Yes	Yes
transmembrane	transmembrane_predicted	Phobius		Yes
transmembrane_phobius	transmembrane_predicted	Almen2009		Yes
transmembrane_sosui	transmembrane_predicted	Almen2009		Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009		Yes

Page 7 of 7Previous

Regulatory Interaction Network (23)

23 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FGF1	P05230	FGFR1	P11362	Yes	Yes		iTALKICELLNETSIGNORProtMapperHINTSignaLink3DIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020Reactome_ProtMapperSPIKE_LCLRdb	HINT:11714710 Cellinker:25772309 BioGRID:8756477 HPRD:11032250 Lit-BM-17:11714710 HINT:10748122 HINT:1697263 BioGRID:9624181 HPMR:8663044 IntAct:18441324 HINT:1309595 SignaLink3:11030354 Cellinker:10336501 Lit-BM-17:7730326 DIP:1722683 HINT:1709094 Baccin2019:8756477 HINT:9624181 HINT:22955284 HINT:11030354 IntAct:25241761 SignaLink3:8576175 Lit-BM-17:10830168 connectomeDB2020:11032250 connectomeDB2020:8756477 ICELLNET:25772309 Lit-BM-17:23597563 Lit-BM-17:11030354 DIP:7730326 BioGRID:1309595 BioGRID:1383494 CellTalkDB:16597617 HINT:1383494 SIGNOR:11030354 IntAct:14613973 connectomeDB2020:10336501 HINT:10830168 HINT:18261743 IntAct:10830168 DIP:22244757 HINT:22244757 HINT:8576175 Lit-BM-17:8576175 HINT:8756477 HINT:22057274 SignaLink3:23331499 HPRD:10336501 Cellinker:8663044 HINT:33961781 SignaLink3:21071413 Lit-BM-17:1722683 Baccin2019:8663044 Baccin2019:11032250 Lit-BM-17:18441324 Lit-BM-17:25241761 Baccin2019:10336501 HINT:28769084 HINT:8321198 Cellinker:11032250 DIP:10830168 HINT:18441324 Cellinker:8756477 SIGNOR:18940940 Cellinker:16597617 HINT:14613973 LRdb:16597617 HINT:8692946 SPIKE_LC:16189514 connectomeDB2020:8663044
FGFR1	P11362	FRS2	Q8WU20	Yes	Yes	Yes	WangSparser_ProtMapperPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEABioGRIDACSNSignaLink3SPIKE_LCLit-BM-17	ACSN:15574420 SignaLink3:9660748 ACSN:16488589 HPRD:11877385 ACSN:11274345 Lit-BM-17:11877385 ACSN:17496910 ACSN:15567848 ProtMapper:25394172 HINT:11877385 HINT:21765395 Lit-BM-17:11090629 ACSN:14585353 ACSN:12040186 SIGNOR:9182757 HINT:11090629 ACSN:11777939 ACSN:11447289 HINT:10464310 Lit-BM-17:10629055 KEA:9632781 ACSN:15173823 HPRD:9632781 SignaLink3:23331499 Lit-BM-17:9660748 BioGRID:10629055 BioGRID:11877385 ACSN:19568798 HPRD:11090629 ACSN:6321473 HINT:9660748 ACSN:11997436 Lit-BM-17:21765395 SPIKE_LC:16189514
FGFR1	P11362	GRB14	Q14449	Yes	Yes		PhosphoPointHPRDHINTSignaLink3Lit-BM-17	HINT:20932831 HPRD:10713090 SignaLink3:10713090 HINT:10713090 SignaLink3:23331499 Lit-BM-17:10713090
FGFR1	P11362	SHB	Q15464	Yes	Yes		PhosphoPointSignaLink3	SignaLink3:7537362 SignaLink3:23331499
FGFR1	P11362	PDP1	Q9P0J1	Yes		Yes	Sparser_ProtMapperPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:24962578 PhosphoSite:24962578 ProtMapper:24486017
FGFR1	P11362	PDK1	Q15118	Yes	Yes		PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:22195962 PhosphoSite:22195962 SIGNOR:22195962
MK01	P28482	FGFR1	P11362	Yes		Yes	WangSparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:27342992 ProtMapper:23405013 SIGNOR:23405013
FGFR1	P11362	HNRPQ	O60506	Yes		Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapper	ProtMapper:12601080 SIGNOR:12601080 phosphoELM:12601080 KEA:12601080
FGFR1	P11362	BCAR1	P56945	Yes	Yes		WangPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMLi2012SIGNOR_ProtMapper	ProtMapper:11019781 SIGNOR:11019781 phosphoELM:12601080 SIGNOR:12601080 ProtMapper:12601080 KEA:12601080
FGFR1	P11362	PDPK1	O15530	Yes	Yes		SIGNOR	SIGNOR:22195962

Page 1 of 3Next

Protein Complex Composition (12)

12 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	FGF23 FGFR1 KL	P11362 Q9GZV9 Q9UEF7	2:1:1	PDB	PDB:7yshPDB:5w21
	FGFR1OP2 STRIP2 TRAF3IP3	Q9NVK5 Q9ULQ0 Q9Y228	0:0:0	hu.MAP2

Page 2 of 2Previous

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27863537

Sequence, Structure & Domains

Sequences

Length

822

Mass

91,868

Sequence

MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

Alternative Products

Event=Alternative splicing; Named isoforms=21; Name=1; Synonyms=Alpha A1, IV; IsoId=P11362-1; Sequence=Displayed; Name=2; Synonyms=Alpha A2; IsoId=P11362-8; Sequence=VSP_009842, VSP_009843; Name=3; Synonyms=Alpha A3; IsoId=P11362-17; Sequence=VSP_009836, VSP_009837; Name=4; Synonyms=Alpha B1; IsoId=P11362-2; Sequence=VSP_002960; Name=5; Synonyms=Alpha B2; IsoId=P11362-9; Sequence=VSP_002960, VSP_009842, VSP_009843; Name=6; Synonyms=Beta A1, II, H2; IsoId=P11362-3; Sequence=VSP_002958; Name=7; Synonyms=Beta A2; IsoId=P11362-10; Sequence=VSP_002958, VSP_009842, VSP_009843; Name=8; Synonyms=Beta B1; IsoId=P11362-4; Sequence=VSP_002958, VSP_002960; Name=9; Synonyms=Beta B2; IsoId=P11362-11; Sequence=VSP_002958, VSP_002960, VSP_009842, VSP_009843; Name=10; Synonyms=Gamma A1; IsoId=P11362-5; Sequence=VSP_002957; Name=11; Synonyms=Gamma A2; IsoId=P11362-12; Sequence=VSP_002957, VSP_009842, VSP_009843; Name=12; Synonyms=Gamma B1; IsoId=P11362-6; Sequence=VSP_002957, VSP_002960; Name=13; Synonyms=Gamma B2; IsoId=P11362-13; Sequence=VSP_002957, VSP_002960, VSP_009842, VSP_009843; Name=14; Synonyms=A, III; IsoId=P11362-7; Sequence=VSP_002959; Name=15; Synonyms=I, H3; IsoId=P11362-14; Sequence=VSP_002958, VSP_002959; Name=16; Synonyms=V; IsoId=P11362-15; Sequence=VSP_009838, VSP_009839; Name=17; Synonyms=H4; IsoId=P11362-16; Sequence=VSP_002958, VSP_009840, VSP_009841; Name=18; Synonyms=H5; IsoId=P11362-18; Sequence=VSP_002958, VSP_002959, VSP_009840, VSP_009841; Name=19; IsoId=P11362-19; Sequence=VSP_038470, VSP_002959, VSP_038471; Name=20; IsoId=P11362-20; Sequence=VSP_041916, VSP_041918; Name=21; IsoId=P11362-21; Sequence=VSP_041917, VSP_002959

Alternative Sequence

1..160; Missing (in isoform 10, isoform 11, isoform 12 and isoform 13); 1..30; MWSWKCLLFWAVLVTATLCTARPSPTLPEQ -> MAAVTRDFGEMLLHSGRVLPAE (in isoform 20); 1; M -> MEARVSLKRRIELTVEYPWRCGALSPTSNCRTGM (in isoform 21); 31..119; Missing (in isoform 6, isoform 7, isoform 8, isoform 9, isoform 15, isoform 17 and isoform 18); 32..61; QPWGAPVEVESFLVHPGDLLQLRCRLRDDV -> CPDLQEAKSCSASFHSITPLPFGLGTRLSD (in isoform 3); 62..822; Missing (in isoform 3); 119; S -> SVPI (in isoform 19); 120..150; DALPSSEDDDDDDDSSSEEKETDNTKPNRMP -> ACPDLQEAKWCSASFHSITPLPFGLGTRLSD (in isoform 16); 148..149; Missing (in isoform 14, isoform 15, isoform 18, isoform 19 and isoform 21); 151..822; Missing (in isoform 16); 313..391; TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV -> VIMAPVFVGQSTGKETTVSGAQVPVGRLSCPRMGSFLTLQAHTLHLSRDLATSPRTSNRGHKVEVSWEQRAAGMGGAGL (in isoform 17 and isoform 18); 313..360; TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE -> HSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRP (in isoform 19); 392..822; Missing (in isoform 17 and isoform 18); 427..428; Missing (in isoform 20); 428..429; Missing (in isoform 4, isoform 5, isoform 8, isoform 9, isoform 12 and isoform 13); 619..662; CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL -> VWNLKAPLVHTPRPGSQECPGDRGQCDEDSRLWPRTGHSPHRLL (in isoform 2, isoform 5, isoform 7, isoform 9, isoform 11 and isoform 13); 663..822; Missing (in isoform 2, isoform 5, isoform 7, isoform 9, isoform 11 and isoform 13)

3D Structural Models

Turn

93..95; 210..213; 461..463; 469..471

Helix

159..161; 199..201; 222..224; 320..323; 475..477; 522..538; 569..574; 591..593; 597..616; 626..628; 648..650; 663..666; 669..674; 679..694; 706..714; 727..736; 741..743; 747..760

Beta Strand

40..42; 51..54; 63..72; 77..81; 83..88; 97..105; 108..116; 151..156; 165..169; 174..177; 180..184; 187..192; 207..209; 214..217; 226..234; 237..248; 265..268; 269..271; 273..276; 286..293; 296..300; 302..304; 307..313; 316..318; 325..328; 333..335; 337..345; 348..359; 478..486; 488..499; 501..503; 508..516; 547..551; 553..555; 558..562; 579..583; 584..586; 629..631; 637..639; 641..643; 653..655; 658..660; 676..678; 722..724

3D Structure

Electron microscopy (2); NMR spectroscopy (2); X-ray crystallography (75)

Domain & Motif Annotations

Compositional Bias

125..135; Acidic residues; 136..145; Basic and acidic residues; 778..792; Polar residues

Domain (CC)

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Isoforms lacking the first Ig-like domain have higher affinity for fibroblast growth factors (FGF) and heparan sulfate proteoglycans than isoforms with all three Ig-like domains.

Domain (FT)

25..119; Ig-like C2-type 1; 158..246; Ig-like C2-type 2; 255..357; Ig-like C2-type 3; 478..767; Protein kinase

Region

120..154; Disordered; 160..177; Heparin-binding; 778..822; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
Fibroblast growth factor receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

Clinical Relevance

Disease Involvement (9)

Cancer-related genesCraniosynostosisDisease variantDwarfismFDA approved drug targetsHoloprosencephalyHypogonadotropic hypogonadismIntellectual disabilityKallmann syndrome

Biomarker

Phase 3; Phase 1; Phase 1/2; Phase 2; Investigative; Approved; Terminated

Drug Targets

FDA approved drug targets

Drugs (107)

AVUTOMETINIB PD-0166285 LUCITANIB NINTEDANIB ESYLATE INFIGRATINIB NULL MUPARFOSTAT ALPELISIB OLVEREMBATINIB GW843682X XL999 TOZASERTIB ARSENIC TRIOXIDE GW441756X BRIVANIB FEXAGRATINIB TG100-801 XL228 ZOTATIFIN MIDOSTAURIN DERAZANTINIB PAZOPANIB GUNAGRATINIB MK-2461 PD173074 PALIFERMIN DEHYDRATED ALCOHOL RG-1530 VANDETANIB AST-487 GO-6976 DOCETAXEL ANHYDROUS CARBOPLATIN HMPL-453 ALISERTIB FGFR INHIBITOR CPL304110 PONATINIB ALSTERPAULLONE MASITINIB RABEPRAZOLE CHEMBL:CHEMBL578061 ZOLIGRATINIB FP-1039 PEMIGATINIB TRAMETINIB DIMETHYL SULFOXIDE CP-547632 MLN-8054 AFIMOXIFENE LENVATINIB ODM-203 CISPLATIN REGORAFENIB PICTILISIB ERDAFITINIB ENMD-981693 VARGATEF TASURGRATINIB ROGARATINIB AZD8055 SORAFENIB BUPARLISIB AZD-4547 ENMD-2076 BRIGATINIB CENISERTIB FUTIBATINIB CHEMBL:CHEMBL546797 DOVITINIB NVP-TAE684 SP-600125 ROMIPLOSTIM LORLATINIB SULFATINIB LY-2874455 ENTRECTINIB HESPERADIN FGFR/CSF-1R INHIBITOR 3D185 VISTUSERTIB PACLITAXEL TAMATINIB ILORASERTIB FINASTERIDE CHEMBL:CHEMBL459729 TOPICAL POTASSIUM DOBESILATE MEK INHIBITOR RO4987655 PRN1371 ORANTINIB CP-459632 FGFR INHIBITOR DEBIO 1347 TRAFERMIN DASATINIB ANHYDROUS SELUMETINIB ETOPOSIDE XL-999 CEDIRANIB FGF-1 SUNITINIB FGF RECEPTOR ANTAGONIST HGS1036 PHA-665752 SIROLIMUS JNJ-7706621 BRIVANIB ALANINATE VACCINE INFIGRATINIB PHOSPHATE CYC-116 PF-562271 KW-2449

Antibody (3)

HPA009029 CAB033614 HPA056402

Interaction Protein (12)

ENSG00000011201ENSG00000039068ENSG00000066468ENSG00000069869ENSG00000096384ENSG00000113578ENSG00000118972ENSG00000124181ENSG00000138685ENSG00000160867ENSG00000168036ENSG00000178394

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Related sentences
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.