Protein detail
CD20
B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)
Protein symbol CD20 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)
Protein Class
CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
57..78; Helical; 85..105; Helical; 121..141; Helical; 189..209; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
B1Bp35CD20FMC7
Gene Description
Membrane spanning 4-domains A1
Chromosome
11
Position
60455846-60470752
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificoligodendrocyte precursor cellSecretome LocationSecreted in brainSecretome FunctionDevelopmental protein
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MS4A1 | CSNK2A2 | P19784 | S | 289 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:7678037ProtMapper:7678037SIGNOR:7678037 |
| MS4A1 | CSNK2A2 | P19784 | S | 231 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:7678037ProtMapper:7678037SIGNOR:7678037 |
| MS4A1 | CSNK2A2 | P19784 | T | 250 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:7678037ProtMapper:7678037SIGNOR:7678037 |
| MS4A1 | CSNK2A1 | P68400 | S | 289 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:7678037ProtMapper:7678037SIGNOR:7678037 |
| MS4A1 | CSNK2A1 | P68400 | T | 250 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:7678037ProtMapper:7678037SIGNOR:7678037 |
| MS4A1 | CSNK2A1 | P68400 | S | 231 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:7678037ProtMapper:7678037SIGNOR:7678037 |
| MS4A1 | PRKCB | P05771 | S | 231 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| b_lymphocyte_calcium | ion_channel | OmniPath | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK22 | P19784 | CD20 | P11836 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | SIGNOR:7678037KEA:7678037ProtMapper:7678037HPRD:7678037 |
| CSK21 | P68400 | CD20 | P11836 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | SIGNOR:7678037KEA:7678037ProtMapper:7678037HPRD:7678037 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 24 | 311969683168598434889606392904593994949031508500382254533279541423161513259503832924238030071318316943443902299040619995407845293246803336635400376863664009834631320591412168844031161638136601 |
Sequence, Structure & Domains
Sequences
Length
297
Mass
33,077
Sequence
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11836-1; Sequence=Displayed; Name=2; IsoId=P11836-2; Sequence=VSP_057058
Alternative Sequence
38..204; Missing (in isoform 2)
3D Structural Models
Turn
206..209
Helix
49..70; 80..83; 86..97; 98..101; 114..142; 153..156; 172..174; 178..185
Beta Strand
107..109
3D Structure
Electron microscopy (7); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
260..276; Acidic residues; 285..297; Polar residues
Region
74..80; Epitope 1; 146..160; Epitope 2; 168..175; Epitope 3 (recognized by antibodies, including Rituximab); 247..297; Disordered
Protein Families
MS4A family
Sequence Similarities
Belongs to the MS4A family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
IBRITUMOMAB TIUXETANVELTUZUMABNULLTRU-015TOSITUMOMAB 131IRITUXIMABOBINUTUZUMABOCRELIZUMABIODINE-131-TOSITUMOMABGLOFITAMABODRONEXTAMABYTTRIUM Y 90 IBRITUMOMAB TIUXETANOCARATUZUMABMONOCLONAL ANTIBODY 1F5LFB-R603OFATUMUMABUBLITUXIMABFBT-A05AUTOLOGOUS ANTI-CD20 CAR TRANSDUCED CD4/CD8 ENRICHED T-CELLS MB-CART20.1TISAGENLECLEUCELANTI-CD20 CAR T CELLS PREPARATIONMOSUNETUZUMABTOSITUMOMABAME-133VPLAMOTAMABDI-LEU16-IL2EPCORITAMABMT-3724