Protein detail
FCGR1
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Entry name FCGR1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Protein Function (2)
- CD markers
- FDA approved drug targets:Biotech drugs
Transmembrane
293..313; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.38
Function & Pathway7
Protein Function (2)
- CD markers
- FDA approved drug targets:Biotech drugs
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
KEGG (11)
- hsa04145 Phagosome
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05202 Transcriptional misregulation in cancer
- KEGG:hsa05221 Acute myeloid leukemia
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Reactome (16)
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1236978 cross presentation of soluble exogenous antigens endosomes
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
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Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence45
Ligand-Receptor Signaling (43)
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
Protein Complex Composition (1)
Sequence, Structure & Domains13
Sequences
Length
374
Mass
42,632
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=P12314-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P12314-2; Sequence=VSP_002637
Alternative Sequence
333..374; HEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT -> GQALEAPTQGCA (in isoform 2)
3D Structural Models
Helix
77..79; 127..129; 160..162; 252..254
Beta Strand
23..28; 31..34; 39..44; 54..62; 67..74; 81..87; 88..91; 96..101; 103..110; 112..115; 120..126; 133..139; 142..149; 153..157; 164..177; 181..186; 193..198; 200..203; 204..206; 208..213; 225..231; 234..241; 244..249; 256..264; 267..272; 276..278
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Motif
173..175; Interaction with Fc glycan
Domain (FT)
22..101; Ig-like C2-type 1; 95..184; Ig-like C2-type 2; 190..277; Ig-like C2-type 3
Region
312..332; Interaction with EPB41L2; 352..374; Disordered
Protein Families (2)
- Immunoglobulin superfamily
- FCGR1 family
Sequence Similarities
Belongs to the immunoglobulin superfamily. FCGR1 family.
Clinical Relevance1
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |