Protein detail
FCGR1
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Protein symbol FCGR1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Protein Function
- CD markers
- FDA approved drug targets:Biotech drugs
Transmembrane
293..313; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- CD markers
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04145 Phagosome
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05202 Transcriptional misregulation in cancer
- KEGG:hsa05221 Acute myeloid leukemia
- KEGG:hsa05322 Systemic lupus erythematosus
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1236978 cross presentation of soluble exogenous antigens endosomes
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-877300 interferon gamma signaling
- R-hsa-913531 interferon signaling
- R-hsa-9658195 leishmania infection
- R-hsa-2029485 role of phospholipids in phagocytosis
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
374
Mass
42,632
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=P12314-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P12314-2; Sequence=VSP_002637
Alternative Sequence
333..374; HEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT -> GQALEAPTQGCA (in isoform 2)
3D Structural Models
Helix
77..79; 127..129; 160..162; 252..254
Beta Strand
23..28; 31..34; 39..44; 54..62; 67..74; 81..87; 88..91; 96..101; 103..110; 112..115; 120..126; 133..139; 142..149; 153..157; 164..177; 181..186; 193..198; 200..203; 204..206; 208..213; 225..231; 234..241; 244..249; 256..264; 267..272; 276..278
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Motif
173..175; Interaction with Fc glycan
Domain (FT)
22..101; Ig-like C2-type 1; 95..184; Ig-like C2-type 2; 190..277; Ig-like C2-type 3
Region
312..332; Interaction with EPB41L2; 352..374; Disordered
Protein Families
- Immunoglobulin superfamily
- FCGR1 family
Sequence Similarities
Belongs to the immunoglobulin superfamily. FCGR1 family.