Protein detail
ANXA3
Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)
Entry name ANXA3 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)
Protein Class
FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ANX3
Gene Description
Annexin A3
Chromosome
4
Position
78551747-78610451
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
323
Mass
36,375
Sequence
MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD
3D Structural Models
Turn
186..188; 280..283
Helix
20..31; 38..45; 50..64; 68..75; 78..88; 91..103; 110..119; 122..136; 140..147; 150..160; 172..185; 194..203; 206..220; 224..231; 234..262; 269..279; 284..295; 299..306; 309..319
Beta Strand
32..35; 105..107; 189..191; 263..266
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Repeat
18..89; Annexin 1; 90..161; Annexin 2; 173..245; Annexin 3; 249..320; Annexin 4
Domain (CC)
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Protein Families
Annexin family
Sequence Similarities
Belongs to the annexin family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
NPY-(13-36) (PIG)NPY-(2-36) (PIG)[D-TRP32]NPY[125I]PYY-(3-36) (HUMAN)NPY-(2-36)C2-NPY (PIG)NPY-(22-36) (PIG)NPY-(3-36) (PIG)[LEU31,PRO34]NPY (PIG)NPY-(26-36) (PIG)[125I]PYYPYY-(13-36) (MOUSE, RAT, PIG)[LEU31,PRO34]NPY[LEU31,PRO34]PYY (HUMAN)JNJ-5207787NPY-(20-36) (PIG)NEUROPEPTIDE Y-(3-36)PEPTIDE YYNEUROPEPTIDE Y[125I]NPY (HUMAN, MOUSE, RAT)NPY[PRO34]PYY (HUMAN)[ALA31,AIB32]NPY (PIG)PYY-(3-36)BIIE0246NPY-(16-36) (PIG)