Protein detail

ANXA3

Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)

Entry name
ANXA3
UniProt ID
P12429
EVMP confidence score
0.38
Supporting publications (n)
2
Transmembrane count
Protein classification
FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)
Protein Class (4)
FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (2)
  • FDA approved drug targets:Small molecule drugs
  • Predicted intracellular proteins
Ensembl
ENSG00000138772
Entrez Gene Symbol
ANXA3
Gene Synonym
ANX3
Gene Description
Annexin A3
Chromosome
4
Position
78551747-78610451
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization6
ANXA3 fluorescence
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function (2)
  • FDA approved drug targets:Small molecule drugs
  • Predicted intracellular proteins
Cellular Component (11)
Page 1 of 2
Molecular Function (5)
Biological Process (3)
Reactome (3)
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence8

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Protein Complex Composition (3)

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ANXA3CPS1P12429P313270:0hu.MAP
ANXA3CPS1DARS2IARS2PDPRP12429P31327Q6PI48Q8NCN5Q9NSE40:0:0:0:0hu.MAP
ANXA3CPS1IARS2P12429P31327Q9NSE40:0:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometry437786918348179062898658527894104
Sequence, Structure & Domains11

Sequences

Length
323
Mass
36,375
Sequence
MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD

3D Structural Models

Turn
186..188; 280..283
Helix
20..31; 38..45; 50..64; 68..75; 78..88; 91..103; 110..119; 122..136; 140..147; 150..160; 172..185; 194..203; 206..220; 224..231; 234..262; 269..279; 284..295; 299..306; 309..319
Beta Strand
32..35; 105..107; 189..191; 263..266
3D Structure
X-ray crystallography (2)

Domain & Motif Annotations

Repeat
18..89; Annexin 1; 90..161; Annexin 2; 173..245; Annexin 3; 249..320; Annexin 4
Domain (CC)
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Protein Families
Annexin family
Sequence Similarities
Belongs to the annexin family.
Clinical Relevance4
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (26)
NPY-(13-36) (PIG)NPY-(2-36) (PIG)[D-TRP32]NPY[125I]PYY-(3-36) (HUMAN)NPY-(2-36)C2-NPY (PIG)NPY-(22-36) (PIG)NPY-(3-36) (PIG)[LEU31,PRO34]NPY (PIG)NPY-(26-36) (PIG)[125I]PYYPYY-(13-36) (MOUSE, RAT, PIG)[LEU31,PRO34]NPY[LEU31,PRO34]PYY (HUMAN)JNJ-5207787NPY-(20-36) (PIG)NEUROPEPTIDE Y-(3-36)PEPTIDE YYNEUROPEPTIDE Y[125I]NPY (HUMAN, MOUSE, RAT)NPY[PRO34]PYY (HUMAN)[ALA31,AIB32]NPY (PIG)PYY-(3-36)BIIE0246NPY-(16-36) (PIG)
Antibody (2)
HPA013398HPA013431
Supporting Publications2
PMIDTitleAbstract
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No abstract available
39558134Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.No abstract available