Protein detail
MYL4
Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform)
Entry name MYL4 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform)
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
ALC1AMLCGT1PRO1957
Gene Description
Myosin light chain 4
Chromosome
17
Position
47200446-47223679
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (5)
Canonical Pathways
M232 Pid ecadherin stabilization pathway
Mediation Categories
Other mediation
Relations & Evidence8
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACTBCALM3HSP90AA1IP6K2MYH7BMYL4MYO19PPIFUBCUNC45A | A7E2Y1P07900P0CG48P0DP25P12829P30405P60709Q96H55Q9H3U1Q9UHH9 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4989 | ||
| ACTBCALM3CORO1AHSP90AA1MCM5MYH7BMYL4MYO19PWP1UBCUNC45A | A7E2Y1P07900P0CG48P0DP25P12829P31146P33992P60709Q13610Q96H55Q9H3U1 | 1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7450 | ||
| CALM3HECTD3MYH7BMYL4MYO19POTEGPPIFSTX8UBCUNC45A | A7E2Y1P0CG48P0DP25P12829P30405Q5T447Q6S5H5Q96H55Q9H3U1Q9UNK0 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6588 | ||
| MYL3MYL4 | P08590P12829 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
197
Mass
21,565
Sequence
MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMSG
Domain & Motif Annotations
Compositional Bias
1..13; Basic and acidic residues; 16..32; Pro residues; 33..42; Basic and acidic residues
Domain (FT)
51..88; EF-hand 1; 130..165; EF-hand 2
Region
1..42; Disordered
Clinical Relevance
Disease Involvement (2)
Atrial fibrillationDisease variant
Related Diseases
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 31414377 | Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics. | No related sentences available |