Protein detail

MYL4

Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform)

Entry name MYL4	UniProt ID P12829	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Ensembl

ENSG00000198336

Entrez Gene Symbol

MYL4

Gene Synonym (4)

ALC1AMLCGT1PRO1957

Gene Description

Myosin light chain 4

Chromosome

Position

47200446-47223679

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificEsophageal apical cells

Function & Pathway8

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG (5)

Reactome (2)

Canonical Pathways

M232 Pid ecadherin stabilization pathway

Mediation Categories

Other mediation

Relations & Evidence8

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACTB CALM3 HSP90AA1 IP6K2 MYH7B MYL4 MYO19 PPIF UBC UNC45A	A7E2Y1 P07900 P0CG48 P0DP25 P12829 P30405 P60709 Q96H55 Q9H3U1 Q9UHH9	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4989
ACTB CALM3 CORO1A HSP90AA1 MCM5 MYH7B MYL4 MYO19 PWP1 UBC UNC45A	A7E2Y1 P07900 P0CG48 P0DP25 P12829 P31146 P33992 P60709 Q13610 Q96H55 Q9H3U1	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7450
CALM3 HECTD3 MYH7B MYL4 MYO19 POTEG PPIF STX8 UBC UNC45A	A7E2Y1 P0CG48 P0DP25 P12829 P30405 Q5T447 Q6S5H5 Q96H55 Q9H3U1 Q9UNK0	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6588
MYL3 MYL4	P08590 P12829	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	2	27894104 38321535

Sequence, Structure & Domains6

Sequences

Length

197

Mass

21,565

Sequence

MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMSG

Domain & Motif Annotations

Compositional Bias

1..13; Basic and acidic residues; 16..32; Pro residues; 33..42; Basic and acidic residues

Domain (FT)

51..88; EF-hand 1; 130..165; EF-hand 2

Region

1..42; Disordered

Clinical Relevance3

Disease Involvement (2)

Atrial fibrillationDisease variant

Drugs (3)

OMECAMTIV MECARBIL DANICAMTIV MAVACAMTEN

Antibody (3)

HPA046859 HPA051884 HPA063034

Supporting Publications1

PMID	Title	Abstract
31414377	Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.	No abstract available