Protein detail
CADH1
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Protein symbol CADH1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Protein Class
Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Head and neck cancers
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- CD markers
- Potential drug targets
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Cancers:Cancers of male genital organs
Transmembrane
710..730; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD324UVOuvomorulin
Gene Description
Cadherin 1
Chromosome
16
Position
68737292-68835537
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificEnterocytes
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Head and neck cancers
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- CD markers
- Potential drug targets
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Cancers:Cancers of male genital organs
Cellular Component
- GO:0005576 extracellular region
- GO:0005768 endosome
- GO:0005802 trans-Golgi network
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0016328 lateral plasma membrane
- GO:0016342 catenin complex
- GO:0016600 flotillin complex
- GO:0030027 lamellipodium
- GO:0030054 cell junction
- GO:0030057 desmosome
- GO:0030864 cortical actin cytoskeleton
- GO:0043296 apical junction complex
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0098794 postsynapse
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008013 beta-catenin binding
- GO:0030506 ankyrin binding
- GO:0032794 GTPase activating protein binding
- GO:0042802 identical protein binding
- GO:0045295 gamma-catenin binding
- GO:0045296 cadherin binding
- GO:0050839 cell adhesion molecule binding
- GO:1990782 protein tyrosine kinase binding
Biological Process
KEGG
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04520 Adherens junction
- KEGG:hsa05100 Bacterial invasion of epithelial cells
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05213 Endometrial cancer
- KEGG:hsa05216 Thyroid cancer
- KEGG:hsa05218 Melanoma
- KEGG:hsa05219 Bladder cancer
- KEGG:hsa05226 Gastric cancer
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-109581 apoptosis
- R-hsa-111465 apoptotic cleavage of cellular proteins
- R-hsa-351906 apoptotic cleavage of cell adhesion proteins
- R-hsa-75153 apoptotic execution phase
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-1474228 degradation of the extracellular matrix
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9924644 developmental lineages of the mammary gland
- R-hsa-9927418 developmental lineage of mammary gland luminal epithelial cells
- R-hsa-9927432 developmental lineage of mammary gland myoepithelial cells
- R-hsa-9938206 developmental lineage of mammary stem cells
- R-hsa-9758919 epithelial mesenchymal transition emt during gastrulation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-9823730 formation of definitive endoderm
- R-hsa-9758941 gastrulation
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-8876493 inla mediated entry of listeria monocytogenes into host cells
- R-hsa-216083 integrin cell surface interactions
- R-hsa-8876384 listeria monocytogenes entry into host cells
- R-hsa-9856651 mitf m dependent gene expression
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-9764790 positive regulation of cdh1 gene transcription
- R-hsa-5357801 programmed cell death
- R-hsa-9764561 regulation of cdh1 function
- R-hsa-9764560 regulation of cdh1 gene transcription
- R-hsa-9764562 regulation of cdh1 mrna translation by micrornas
- R-hsa-9768727 regulation of cdh1 posttranslational processing and trafficking to plasma membrane
- R-hsa-9759476 regulation of homotypic cell cell adhesion
- R-hsa-9926550 regulation of mitf m dependent genes involved in extracellular matrix focal adhesion and epithelial to mesenchymal transition
- R-hsa-5626467 rho gtpases activate iqgaps
- R-hsa-195258 rho gtpase effectors
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-9856649 transcriptional and post translational regulation of mitf m expression and activity
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
26 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CDH1 | PRKCA | P17252 | T | 790 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:27203386 |
| CDH1 | CFH | P08603 | S | 838 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28163245 |
| CDH1 | CFH | P08603 | S | 840 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28163245 |
| CDH1 | CSNK1A1L | Q8N752 | S | 846 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:17353278 |
| CDH1 | CHKA | P35790 | S | 846 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:26556953 |
| CDH1 | PLK1 | P53350 | S | 146 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:23972993 |
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Ligand-Receptor Signaling
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| basolateral_cell_membrane | plasma_membrane | LOCATE | No | No | No | Yes | No |
Regulatory Interaction Network
32 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TBK1 | Q9UHD2 | CADH1 | P12830 | Yes | No | Yes | SIGNOR | SIGNOR:33310066 |
| CDK5 | Q00535 | CADH1 | P12830 | Yes | No | Yes | SIGNOR | SIGNOR:22836916 |
| ADA10 | O14672 | CADH1 | P12830 | Yes | Yes | No | WangSIGNOR | SIGNOR:26284334 |
| UBP28 | Q96RU2 | CADH1 | P12830 | Yes | Yes | No | SIGNOR | SIGNOR:18662541 |
| COMPLEX:P20248_P24941 | CADH1 | P12830 | Yes | Yes | Yes | SPIKE_LCSIGNOR | SIGNOR:23972993SPIKE_LC:18319725SPIKE_LC:10548110 | |
| COMPLEX:P63208_Q13616_Q9Y297 | CADH1 | P12830 | Yes | No | Yes | SIGNOR | SIGNOR:23972993 | |
| ARVC | O00192 | CADH1 | P12830 | Yes | Yes | No | HPRDSIGNOR | HPRD:11058098SIGNOR:14610055 |
| KC1D | P48730 | CADH1 | P12830 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperKEAphosphoELM_KEAphosphoELMPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17353278PhosphoSite:17353278KEA:17353278phosphoELM:17353278PhosphoSite:22770219 |
| KPCD1 | Q15139 | CADH1 | P12830 | Yes | Yes | No | WangSPIKE_LCSIGNOR | SIGNOR:15695390SPIKE_LC:15695390 |
| MARH8 | Q5T0T0 | CADH1 | P12830 | Yes | No | Yes | SIGNOR | SIGNOR:33540066 |
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CDH1-CKS1B complex | CDH1CKS1B | P12830P61024 | 1:1 | CompleatCORUM | CORUM:5319Compleat:HC32 | 15014502 |
| CDH1-SKP2 complex | CDH1SKP2 | P12830Q13309 | 1:1 | CompleatCORUM | CORUM:5320Compleat:HC3070 | 15014502 |
| CDH15HSF1LIG4MSANTD3NACC1NFIL3PARP1RFC1RFC2RFC4RFC5RPA2TFAMXRCC5XRCC6 | P09874P12956P13010P15927P35249P35250P35251P40937P49917P55291Q00059Q00613Q16649Q96H12Q96RE7 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6205 | ||
| CDH1 | P12830 | 2 | PDB | PDB:4zt1PDB:4ztePDB:7stz | ||
| CDH1LRPPRCSLIRP | P12830P42704Q9GZT3 | 0:0:0 | hu.MAP2 | |||
| CDH1SLIRP | P12830Q9GZT3 | 0:0 | hu.MAP | |||
| CDH1CTNNA3 | P12830Q9UI47 | 0:0 | hu.MAP2 | |||
| CDH17 | Q12864 | 2 | PDB | PDB:7ev1PDB:6ulmPDB:7cym |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30865381 |
Sequence, Structure & Domains
Sequences
Length
882
Mass
97,456
Sequence
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P12830-1; Sequence=Displayed; Name=2; IsoId=P12830-2; Sequence=VSP_055586
Alternative Sequence
380..440; Missing (in isoform 2)
3D Structural Models
Turn
196..198; 209..211; 222..224; 292..294; 321..323; 335..337; 407..409; 429..432; 444..446; 537..539; 553..555; 635..637
Helix
181..184; 350..352; 769..771
Beta Strand
163..166; 169..177; 189..195; 199..201; 204..207; 213..216; 227..235; 241..243; 246..253; 261..263; 265..272; 280..283; 301..309; 316..319; 325..328; 340..348; 356..366; 374..384; 394..396; 410..417; 423..428; 433..440; 448..460; 470..477; 485..498; 504..507; 522..527; 533..535; 541..544; 557..568; 571..573; 576..586; 594..596; 599..607; 610..615; 622..625; 627..633; 638..644; 648..656; 660..673; 675..691
3D Structure
Electron microscopy (3); X-ray crystallography (18)
Domain & Motif Annotations
Compositional Bias
755..767; Acidic residues
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and strengthen the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
155..262; Cadherin 1; 263..375; Cadherin 2; 376..486; Cadherin 3; 487..593; Cadherin 4; 594..697; Cadherin 5
Region
747..767; Disordered; 758..769; Required for binding CTNND1 and PSEN1; 811..882; Required for binding alpha, beta and gamma catenins
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantEctodermal dysplasia
Interaction Protein
ENSG00000004897ENSG00000044115ENSG00000077782ENSG00000080815ENSG00000146648ENSG00000166689ENSG00000168036ENSG00000172531ENSG00000197122ENSG00000198561
Interaction Count
10
Interaction Dataset
intact_biogridintact_biogrid_opencell_bioplex