Protein detail

SRC

Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Protein symbol
SRC
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
Protein classification
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Entrez Gene Symbol
Gene Synonym
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

128 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
SRCLYNP07948Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:26536590
SRCINSP01308Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:24632852ProtMapper:25748795
SRCHGFP14210Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:23524339
SRCAGTP01019Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:26751575
SRCBDNFP23560Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:26252487
SRCHYOU1Q9Y4L1Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:19956670
SRCTGP01266Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:18314876
SRCTGFB1P01137Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:21829547
SRCRENBPP51606Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:28178976
SRCP69208P69208Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:29464048
Page 12 of 13PreviousNext

Ligand-Receptor Signaling

13 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_adhesioncell_adhesionCellinkerYesYesNoNoNo
adhesionadhesionOmniPathYesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
Page 1 of 2Next

Regulatory Interaction Network

362 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
SRCP12931ITALP20701YesYesYesSIGNORSIGNOR:25624455
SRCP12931PAK2Q13177YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALit-BM-17DOMINOHPRDKinexus_KEAWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperSPIKE_LCKEA:12215529phosphoELM:12215529Lit-BM-17:16374509SPIKE_LC:16374509HPRD:16374509ProtMapper:12215529HPRD:12215529SIGNOR:12215529DOMINO:16374509
SRCP12931TERTO14746YesNoYesHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phosHPRD:12808100dbPTM:18829466KEA:12808100dbPTM:12808100ProtMapper:12808100PhosphoSite:24413564PhosphoSite:26908447PhosphoSite:12808100HPRD-phos:12808100ProtMapper:33132941ProtMapper:28264499ProtMapper:32502898ProtMapper:20211239ProtMapper:31903880SIGNOR:12808100PhosphoSite:18829466phosphoELM:12808100ProtMapper:22872811ProtMapper:31781563
SRCP12931HLAAP04439YesNoNoBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapperphosphoELM:6304688HPRD:6304688ProtMapper:15212693ProtMapper:6304688ProtMapper:6333425HPRD:6333425SIGNOR:6304688
SRCP12931ACHA7P36544YesNoYesphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:16251431phosphoELM:16251431ProtMapper:16251431PhosphoSite:16251431SIGNOR:16251431
SRCP12931PKHG2Q9H7P9YesYesNoSparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:24378532ProtMapper:24378532PhosphoSite:24378532
SRCP12931WBP2Q969T9YesYesNoiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:21642474SIGNOR:21642474
SRCP12931ESR1P03372YesYesNoHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEALi2012Lit-BM-17HPRDCui2007IntActWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperNetPathHPRD-phosHINT:22328528ProtMapper:25275301Lit-BM-17:17627277ProtMapper:33316954HINT:17284441HINT:16957778HINT:14963108HINT:17627277HINT:12630920IntAct:23065768ProtMapper:7539106Lit-BM-17:23065768HINT:15140878Lit-BM-17:14766010Lit-BM-17:15020686ProtMapper:31015428IntAct:14963108Lit-BM-17:17284441BioGRID:15784253HPRD:12736255HPRD:7539106KEA:7539106Lit-BM-17:17921256ProtMapper:22865929ProtMapper:25597633phosphoELM:7539106HINT:12736255HPRD-phos:7539106Lit-BM-17:17400812NetPath:11032808HINT:17921256ProtMapper:30148069HINT:11013076HINT:24498420SIGNOR:9500442HINT:23065768Lit-BM-17:15784253ProtMapper:27472465HINT:10454579HINT:7539106HINT:14766010HINT:17363140iPTMnet:9500442HPRD:15140878Lit-BM-17:11013076Lit-BM-17:14963108HINT:15784253HINT:17043237Lit-BM-17:16957778Lit-BM-17:12630920HINT:18451880ProtMapper:32532126ProtMapper:9500442
SRCP12931WASF1Q92558YesYesNoSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapperProtMapper:16317717phosphoELM:16317717KEA:16317717ProtMapper:23354023SIGNOR:16317717
SRCP12931MPZL1O95297YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALi2012HPRDWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSPIKE_LCHPRD-phosHPRD-phos:18669648HPRD-phos:11751924ProtMapper:18707149phosphoELM:11751924ProtMapper:15212693KEA:10681522ProtMapper:11751924ProtMapper:17016520HPRD-phos:18578522HPRD-phos:20068231HPRD-phos:10681522ProtMapper:19664994PhosphoSite:11751924HPRD:11751924KEA:11751924HPRD:10681522HPRD-phos:18707149ProtMapper:10681522ProtMapper:18578522SIGNOR:11751924ProtMapper:20068231ProtMapper:18669648HPRD-phos:19664994HPRD-phos:17016520SPIKE_LC:16189514
Page 20 of 37PreviousNext

Protein Complex Composition

48 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ACTL6ACREBBPDMAP1EP300GATA6H2AXH3C11H4C4KAT2AKAT2BKAT5PRKDCRUVBL1RUVBL2SRCAPO96019P16104P62805P68431P78527Q09472Q6ZRS2Q92793Q92830Q92831Q92908Q92993Q9NPF5Q9Y230Q9Y2651:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC6805
CREBBPESR1FOXO1RARASRCP03372P10276P12931Q12778Q927931:1:1:1:1CompleatCFinderCompleat:HC6957
PGRSRCP06401P129310:0KEGG-MEDICUS
CDC5LMEA1MSH2MSH6RBM10RSRC2P0DW28P43246P52701Q16626Q7L4I2Q994590:0:0:0:0:0hu.MAP2
NR1H2RARARXRARXRBSRCP10276P12931P19793P28702P550551:1:1:1:1CompleatCFinderCompleat:HC7666
SRCP129312PDBPDB:1yolPDB:1yi6PDB:1a07PDB:6c4sPDB:4mxxPDB:1yojPDB:8haqPDB:4mxzPDB:8jf3PDB:9ofxPDB:1a1ePDB:1a09PDB:2bdfPDB:1a08PDB:6e6ePDB:4mxyPDB:1a1bPDB:4mxoPDB:1a1aPDB:1yomPDB:1a1cPDB:7otePDB:7t1u
PTPN1SRCP12931P180312:2PDBPDB:3zmpPDB:3zmq
PTPN21SRCP12931Q168251:1PDBPDB:8gwh
EEPD1SRCP12931Q7L9B90:0hu.MAP
CBLCSRCP12931Q9ULV81:1PDBPDB:3vro
Page 4 of 5PreviousNext

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blottingFlow cytometry3315085003279541440091455
Sequence, Structure & Domains

Sequences

Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)

3D Structural Models

Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)

Domain & Motif Annotations

Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid