Protein detail

SRC

Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Protein symbol
SRC
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
Protein classification
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Basic Information
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Entrez Gene Symbol
Gene Synonym
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

128 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
SRCLYNP07948Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:26536590
SRCINSP01308Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:24632852ProtMapper:25748795
SRCHGFP14210Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:23524339
SRCAGTP01019Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:26751575
SRCBDNFP23560Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:26252487
SRCHYOU1Q9Y4L1Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:19956670
SRCTGP01266Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:18314876
SRCTGFB1P01137Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:21829547
SRCRENBPP51606Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:28178976
SRCP69208P69208Y419phosphorylationSparser_ProtMapperProtMapperProtMapper:29464048
Page 12 of 13PreviousNext

Ligand-Receptor Signaling

13 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_adhesioncell_adhesionCellinkerYesYesNoNoNo
adhesionadhesionOmniPathYesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
Page 1 of 2Next

Regulatory Interaction Network

362 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
FAK2Q14289SRCP12931YesYesNoKEGG-MEDICUSProtMapperHINTSignaLink3InnateDBLi2012NCI-PID_ProtMapperHPRDCui2007CA1IntActCancerCellMapWangELMTCRcuration_SignaLink3AdhesomeNetPathSPIKE_LCSPIKESPIKE_LC:14963038HINT:14963038Adhesome:10777553Adhesome:14739300SignaLink3:23109003CA1:10329689HINT:11149930InnateDB:14963038HINT:10521452Adhesome:14963038Adhesome:12345678IntAct:10521452Adhesome:11149930SPIKE:14963038CancerCellMap:14963038ELM:11149930ELM:10521452HINT:8849729CA1:9560226ELM:10867021Adhesome:19380485IntAct:11149930SignaLink3:9148935NetPath:14963038Adhesome:10329689CA1:8849729SPIKE:16713569HPRD:10777553Adhesome:11274221IntAct:8849729CA1:11274221Adhesome:10521452HPRD:8849729Adhesome:9560226ELM:8849729SPIKE_LC:16713569Adhesome:8849729Adhesome:9556630
SRCP12931ADA17P78536YesYesNoSIGNORSIGNOR:25371038
SRCP12931RAF1P04049YesYesNoSPIKEKEGG-MEDICUSHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDKinexus_KEAPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperReactome_ProtMapperSPIKE_LCHPRD-phosPhosphoSite:7692235ProtMapper:17097642ProtMapper:8876196HPRD:8876196HPRD:10205168ProtMapper:25794709KEA:15258589HPRD:17097642HPRD-phos:17097642ProtMapper:16170185KEA:8876196SIGNOR:12551923ProtMapper:12952943SPIKE:16189514ProtMapper:10205168ProtMapper:16630891ProtMapper:11376654SIGNOR:10998357PhosphoSite:11134016ProtMapper:26251594ProtMapper:7692235KEA:17097642KEA:15710605PhosphoSite:9689060ProtMapper:10998357SIGNOR:7692235phosphoELM:10205168HPRD:7517401ProtMapper:12551923KEA:10205168ProtMapper:22592532ProtMapper:29063113PhosphoSite:28846113SPIKE_LC:16189514
SRCP12931STAT1P42224YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAInnateDBLi2012HPRDCui2007CancerCellMapWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDphosphoELMSIGNOR_ProtMapperNetPathSPIKE_LCSPIKENetPath:10358079KEA:10748192KEA:15322115KEA:12637327SPIKE:16189514KEA:11839738KEA:11438544InnateDB:14978237KEA:7592750KEA:12817007KEA:10918587KEA:11152457CancerCellMap:10358079KEA:7690989ProtMapper:14978237SIGNOR:14978237SPIKE:10358079KEA:10982844BioGRID:9344858KEA:11294897HPRD:9344858KEA:9355737KEA:7657660SPIKE_LC:10358079phosphoELM:14978237KEA:7543024SPIKE_LC:16189514
SRCP12931PLCG1P19174YesYesNoSPIKEHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAHPRDCui2007CA1WangNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperAdhesomeNetPathReactome_ProtMapperSPIKE_LCHPRD-phosHPRD:7510703ProtMapper:7682059KEA:16126727Adhesome:8388373KEA:16153436KEA:8885868ProtMapper:8885868HPRD:1689310SPIKE_LC:18594017NetPath:18594017ProtMapper:34143834ProtMapper:17016520SPIKE:18594017HPRD-phos:20068231CA1:8388373HPRD-phos:7682059ProtMapper:17531443KEA:12601080CA1:7682059KEA:7682059ProtMapper:17389395HPRD-phos:1689310KEA:8657103KEA:1689310HPRD:8885868ProtMapper:1689310ProtMapper:8657103HPRD:7682059SPIKE:16713569HPRD-phos:17389395HPRD-phos:8885868KEA:1708307Adhesome:7682059HPRD:8657103ProtMapper:16497976SIGNOR:7682059HPRD-phos:8657103ProtMapper:20068231HPRD-phos:16497976Adhesome:7510703SPIKE_LC:16713569KEA:17570479KEA:16038803HPRD-phos:17016520
SRCP12931TGFR2P37173YesYesNoSparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSignaLink3SIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapperProtMapper:34193161ProtMapper:16859511SIGNOR:19114990ProtMapper:26357075ProtMapper:26849234ProtMapper:17440088ProtMapper:21532881ProtMapper:19114990SignaLink3:19114990SignaLink3:23331499
EPHA3P29320SRCP12931YesYesNoSIGNORSignaLink3SignaLink3:23331499SIGNOR:9632142SignaLink3:9632142
EPHB2P29323SRCP12931YesYesNoPhosphoPointSIGNORProtMapperHPRDHINTSignaLink3Li2012WangLit-BM-17PhosphoSite_ProtMapperLit-BM-17:10644995Lit-BM-17:9632142SignaLink3:10644995HPRD:18713744HINT:9632142HINT:10644995SignaLink3:18713744SIGNOR:9632142SignaLink3:23331499HPRD:9632142SignaLink3:9632142
SRCP12931DDR2Q16832YesYesNoHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAHPRDKinexus_KEAPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LCSIGNOR:16186108ProtMapper:16186108SPIKE_LC:11884411PhosphoSite:11884411KEA:11884411dbPTM:18083107PhosphoSite:16186108HPRD:11884411ProtMapper:29701112ProtMapper:28270508KEA:16186108HPRD:16186108
DDR2Q16832SRCP12931YesYesNoProtMapperHPRDSignaLink3SPIKE_LCREACH_ProtMapperSignaLink3:16186108SignaLink3:11884411SPIKE_LC:11884411ProtMapper:21288331HPRD:11884411SignaLink3:23331499HPRD:16186108
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Protein Complex Composition

48 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ACTL6ACREBBPDMAP1EP300GATA6H2AXH3C11H4C4KAT2AKAT2BKAT5PRKDCRUVBL1RUVBL2SRCAPO96019P16104P62805P68431P78527Q09472Q6ZRS2Q92793Q92830Q92831Q92908Q92993Q9NPF5Q9Y230Q9Y2651:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC6805
CREBBPESR1FOXO1RARASRCP03372P10276P12931Q12778Q927931:1:1:1:1CompleatCFinderCompleat:HC6957
PGRSRCP06401P129310:0KEGG-MEDICUS
CDC5LMEA1MSH2MSH6RBM10RSRC2P0DW28P43246P52701Q16626Q7L4I2Q994590:0:0:0:0:0hu.MAP2
NR1H2RARARXRARXRBSRCP10276P12931P19793P28702P550551:1:1:1:1CompleatCFinderCompleat:HC7666
SRCP129312PDBPDB:1yolPDB:1yi6PDB:1a07PDB:6c4sPDB:4mxxPDB:1yojPDB:8haqPDB:4mxzPDB:8jf3PDB:9ofxPDB:1a1ePDB:1a09PDB:2bdfPDB:1a08PDB:6e6ePDB:4mxyPDB:1a1bPDB:4mxoPDB:1a1aPDB:1yomPDB:1a1cPDB:7otePDB:7t1u
PTPN1SRCP12931P180312:2PDBPDB:3zmpPDB:3zmq
PTPN21SRCP12931Q168251:1PDBPDB:8gwh
EEPD1SRCP12931Q7L9B90:0hu.MAP
CBLCSRCP12931Q9ULV81:1PDBPDB:3vro
Page 4 of 5PreviousNext

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blottingFlow cytometry3315085003279541440091455
Sequence, Structure & Domains

Sequences

Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)

3D Structural Models

Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)

Domain & Motif Annotations

Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid