Protein detail

SRC

Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Protein symbol
SRC
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
Protein classification
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Basic Information
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Entrez Gene Symbol
Gene Synonym
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

128 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
SRCPTPN6P29350Y419dephosphorylationHPRDDEPODHPRD:9261115DEPOD:9261115
SRCPTPN6P29350Y530dephosphorylationHPRDDEPODHPRD:8647855HPRD:12468645HPRD:9261115DEPOD:9261115
SRCPTPN6P29350Y419phosphorylationSIGNOR_ProtMapperProtMapperProtMapper:9261115
SRCPTPN6P29350Y530phosphorylationSIGNOR_ProtMapperProtMapperProtMapper:17974954
SRCPTPRAP18433Y530dephosphorylationHPRDHPRD:8647855HPRD:12468645HPRD:10698938HPRD:9261115HPRD:7691597HPRD:15588985HPRD:10787408
SRCPTPRAP18433Y419phosphorylationNCI-PID_ProtMapperREACH_ProtMapperProtMapperProtMapper:28656243ProtMapper:10228160ProtMapper:11238661ProtMapper:16227616
SRCPTPRAP18433Y530phosphorylationNCI-PID_ProtMapperSIGNOR_ProtMapperProtMapperProtMapper:10698938ProtMapper:10228160ProtMapper:16227616ProtMapper:11238661ProtMapper:7691597ProtMapper:17974954
SRCPTPN2P17706Y419dephosphorylationHPRDDEPODHPRD:15696169DEPOD:15696169
SRCPTPN2P17706Y419phosphorylationNCI-PID_ProtMapperSparser_ProtMapperProtMapperProtMapper:27611995ProtMapper:18948751ProtMapper:15696169
SRCPIK3CGP48736S39phosphorylationREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapperProtMapper:27169346
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Ligand-Receptor Signaling

13 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_adhesioncell_adhesionCellinkerYesYesNoNoNo
adhesionadhesionOmniPathYesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
Page 1 of 2Next

Regulatory Interaction Network

362 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
ROR1Q01973SRCP12931YesYesNoREACH_ProtMapperSIGNORProtMapperIntActProtMapper:22439932IntAct:22439932SIGNOR:22439932
SRCP12931AREGP15514YesYesNoSIGNORSIGNOR:17251915
SRCP12931PP2AAP67775YesNoYesphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperReactome_ProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:23796501PhosphoSite:27013170PhosphoSite:25726524PhosphoSite:23436320PhosphoSite:22771321PhosphoSite:25931585PhosphoSite:32130916PhosphoSite:24997451PhosphoSite:17635907PhosphoSite:22299660PhosphoSite:21554241SIGNOR:23796501PhosphoSite:20558158PhosphoSite:23251465PhosphoSite:24395787PhosphoSite:21791414PhosphoSite:17303700PhosphoSite:25003662PhosphoSite:24676687PhosphoSite:23926298PhosphoSite:16286244PhosphoSite:21292165PhosphoSite:10978272PhosphoSite:17394530PhosphoSite:31992581PhosphoSite:23222956PhosphoSite:12921784PhosphoSite:26378614PhosphoSite:1325671PhosphoSite:18208556
PP2AAP67775SRCP12931YesNoYesSIGNOR_ProtMapperSIGNORProtMapperDEPODDEPOD:10322434ProtMapper:18069897SIGNOR:18069897
SRCP12931CTND2Q9UQB3YesYesNoREACH_ProtMapperSIGNORProtMapperSIGNOR:24412473ProtMapper:24412473
SRCP12931AFAP1Q8N556YesNoNoPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDKEAHPRD_KEALi2012SIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapperPhosphoSite:9655255SIGNOR:9655255HPRD-phos:9655255KEA:9655255ProtMapper:9655255HPRD:9655255
SRCP12931CHIOP52757YesNoYesPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapperProtMapper:17560670SIGNOR:17560670
SRCP12931BTKQ06187YesYesNoWangSparser_ProtMapperiPTMnetSIGNORProtMapperKinexus_KEAKEASIGNOR_ProtMapperREACH_ProtMapperKEA:10051622ProtMapper:29455639ProtMapper:23170196ProtMapper:9052864ProtMapper:31949019ProtMapper:10196129ProtMapper:23449308ProtMapper:8629002ProtMapper:19109164ProtMapper:8630736SIGNOR:8629002ProtMapper:26165234
SRCP12931RHG05Q13017YesYesNoPhosphoSite_MIMPMIMPAdhesomeiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperWangREACH_ProtMapperPhosphoSite_ProtMapperAdhesome:10592173SIGNOR:24858043Adhesome:7542246SIGNOR:9819392ProtMapper:24858043
SRCP12931RRASP10301YesYesYesDOMINOBEL-Large-Corpus_ProtMapperWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSPIKE_LCphosphoELM:11682467ProtMapper:15212693SIGNOR:11682467KEA:10570155ProtMapper:11682467SPIKE_LC:17474147PhosphoSite:10570155KEA:11682467DOMINO:17474147PhosphoSite:11682467
Page 12 of 37PreviousNext

Protein Complex Composition

48 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ACTL6ACREBBPDMAP1EP300GATA6H2AXH3C11H4C4KAT2AKAT2BKAT5PRKDCRUVBL1RUVBL2SRCAPO96019P16104P62805P68431P78527Q09472Q6ZRS2Q92793Q92830Q92831Q92908Q92993Q9NPF5Q9Y230Q9Y2651:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC6805
CREBBPESR1FOXO1RARASRCP03372P10276P12931Q12778Q927931:1:1:1:1CompleatCFinderCompleat:HC6957
PGRSRCP06401P129310:0KEGG-MEDICUS
CDC5LMEA1MSH2MSH6RBM10RSRC2P0DW28P43246P52701Q16626Q7L4I2Q994590:0:0:0:0:0hu.MAP2
NR1H2RARARXRARXRBSRCP10276P12931P19793P28702P550551:1:1:1:1CompleatCFinderCompleat:HC7666
SRCP129312PDBPDB:1yolPDB:1yi6PDB:1a07PDB:6c4sPDB:4mxxPDB:1yojPDB:8haqPDB:4mxzPDB:8jf3PDB:9ofxPDB:1a1ePDB:1a09PDB:2bdfPDB:1a08PDB:6e6ePDB:4mxyPDB:1a1bPDB:4mxoPDB:1a1aPDB:1yomPDB:1a1cPDB:7otePDB:7t1u
PTPN1SRCP12931P180312:2PDBPDB:3zmpPDB:3zmq
PTPN21SRCP12931Q168251:1PDBPDB:8gwh
EEPD1SRCP12931Q7L9B90:0hu.MAP
CBLCSRCP12931Q9ULV81:1PDBPDB:3vro
Page 4 of 5PreviousNext

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blottingFlow cytometry3315085003279541440091455
Sequence, Structure & Domains

Sequences

Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)

3D Structural Models

Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)

Domain & Motif Annotations

Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid