Protein detail
SRC
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Entry name SRC | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class (8)
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function (9)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway7
Protein Function (9)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (23)
- GO:0002102 podosome
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005743 mitochondrial inner membrane
- GO:0005764 lysosome
- GO:0005770 late endosome
- GO:0005829 cytosol
- GO:0005884 actin filament
- GO:0005886 plasma membrane
Page 1 of 3
Molecular Function (23)
- GO:0004672 protein kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005102 signaling receptor binding
- GO:0005158 insulin receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016004 phospholipase activator activity
Page 1 of 3
Biological Process (3)
KEGG (45)
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa01522 Endocrine resistance
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04137 Mitophagy - animal
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04370 VEGF signaling pathway
Page 1 of 5
Reactome (136)
- R-hsa-9032500 activated ntrk2 signals through fyn
- R-hsa-9603381 activated ntrk3 signals through pi3k
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-9612973 autophagy
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1500931 cell cell communication
Page 1 of 14
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence552
Enzyme-Mediated Modification (128)
128 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SRC | CHKA | P35790 | Y | 530 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22823952ProtMapper:15845350ProtMapper:28784162ProtMapper:26453921 |
| SRC | MATK | P42679 | Y | 530 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:27600824ProtMapper:26453921 |
| SRC | PAG1 | Q9NWQ8 | Y | 530 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:21940449ProtMapper:27600824ProtMapper:28178691ProtMapper:7680927ProtMapper:21632985ProtMapper:22823952ProtMapper:23159740ProtMapper:18614016ProtMapper:10838156ProtMapper:28098256ProtMapper:19827767ProtMapper:22848394ProtMapper:28784162ProtMapper:16115959ProtMapper:19874824ProtMapper:15845350ProtMapper:20657842ProtMapper:26030592 |
| SRC | PTPRE | P23469 | Y | 530 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15522235 |
| SRC | PTPN21 | Q16825 | Y | 530 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15143158 |
| SRC | ITGB3 | P05106 | Y | 530 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:16115959 |
| SRC | EGFR | P00533 | Y | 419 | phosphorylation | RLIMS-P_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22957061 |
| SRC | EGFR | P00533 | Y | 216 | phosphorylation | RLIMS-P_ProtMapperREACH_ProtMapperProtMapper | ProtMapper:14760089ProtMapper:16769082 |
| SRC | BSG | P35613 | Y | 419 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:25428919 |
| SRC | IL25 | Q9H293 | Y | 419 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:27462789 |
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network (362)
362 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | NTRK1 | P04629 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperKEALi2012REACH_ProtMapperNetworKIN_KEA | KEA:17570479ProtMapper:23319303ProtMapper:16860569SIGNOR:20219970 |
| SRC | P12931 | SMAD3 | P84022 | Yes | Yes | No | SIGNOR | SIGNOR:28943431 |
| SRC | P12931 | STA5B | P51692 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperHPRD-phos | KEA:12621061HPRD-phos:12621061ProtMapper:12429742ProtMapper:17997837SIGNOR:12621061phosphoELM:12621061HPRD:12621061ProtMapper:12621061ProtMapper:19438593 |
| SRC | P12931 | SPN90 | Q9NZQ3 | Yes | Yes | No | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:23342115SIGNOR:23342115 |
| SRC | P12931 | PK3C3 | Q8NEB9 | Yes | Yes | No | SIGNOR | SIGNOR:24582588 |
| SRC | P12931 | ERBB2 | P04626 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperHPRDHINTIntActCellinkerWangREACH_ProtMapperPhosphoSite_ProtMapper | HINT:19372587HPRD:7542762SIGNOR:26114632ProtMapper:11250711ProtMapper:30884851IntAct:11940572HINT:7797556Cellinker:22279592HINT:21075308HINT:22973453IntAct:21075308HINT:11940572 |
| SRC | P12931 | NEDD4 | P46934 | Yes | Yes | No | PhosphoSite_norefPhosphoSiteSIGNOR | SIGNOR:25292214PhosphoSite:25292214 |
| SRC | P12931 | CTRO | O14578 | Yes | Yes | No | SIGNOR | SIGNOR:27551053 |
| SRC | P12931 | ARHG5 | Q12774 | Yes | Yes | No | SIGNOR | SIGNOR:21525037 |
| SRC | P12931 | CNTP1 | P78357 | Yes | No | Yes | HPRDPhosphoPointSIGNOR | SIGNOR:11672527HPRD:9118959 |
Protein Complex Composition (48)
48 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PAXBP1RSRC1SNRPBTFIP11TXNL4A | P14678P83876Q96IZ7Q9UBB9Q9Y5B6 | 0:0:0:0:0 | hu.MAP | |||
| ASF1ACREBBPFOXA1FOXA2H2AXH3-4H3C11H4C4INO80KAT2BKAT5RUVBL1RUVBL2SRCAP | P16104P55317P62805P68431Q16695Q6ZRS2Q92793Q92831Q92993Q9ULG1Q9Y230Q9Y261Q9Y265Q9Y294 | 1:1:2:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6780 | ||
| CDC5LMEA1MSH2MSH6RBM10RSRC2 | P43246P52701P98175Q16626Q7L4I2Q99459 | 0:0:0:0:0:0 | hu.MAP2 | |||
| BCAS4BLOC1S3SRCIN1 | Q6QNY0Q8TDM0Q9C0H9 | 0:0:0 | hu.MAP | |||
| BCAS4BLOC1S3BLOC1S6SRCIN1 | Q6QNY0Q8TDM0Q9C0H9Q9UL45 | 0:0:0:0 | hu.MAP | |||
| BAHD1H2BC1H2BC13MIER1SRCAP | Q6ZRS2Q8N108Q8TBE0Q96A08Q99880 | 0:0:0:0:0 | hu.MAP2 | |||
| PAXBP1RSRC1TFIP11 | Q96IZ7Q9UBB9Q9Y5B6 | 0:0:0 | hu.MAPhu.MAP2 | |||
| PAXBP1RSRC1 | Q96IZ7Q9Y5B6 | 0:0 | hu.MAP |
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Sequence, Structure & Domains15
Sequences
Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)
3D Structural Models
Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)
Domain & Motif Annotations
Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance9
Disease Involvement (4)
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases (33)
Acute myeloid leukaemiaBCR-ABL1-negative chronic myeloid leukaemiaBrain cancerBreast cancerCardiovascular diseaseCervical cancerChronic obstructive pulmonary diseaseEndometrial cancerEpidermal dysplasiasFallopian tube cancerGastrointestinal stromal tumourGram-positive bacterial infectionIschemiaLeiomyosarcomaLow bone mass disorderMalignant digestive organ neoplasmMalignant haematopoietic neoplasmMature B-cell leukaemiaMetastatic digestive system neoplasmMotor neuron diseaseMultiple myelomaMultiple sclerosisMyeloproliferative neoplasmNasopharyngeal cancerOsteosarcomaOvarian cancerPancreatic cancerParkinsonismPeritoneal cancerPostoperative inflammationSarcomaSolid tumour/cancerSynovial sarcoma
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Drugs (55)
CEDIRANIBCLOZAPINEBOSUTINIBNULLTG100-801TYRPHOSTIN A9KX2-361CHEMBL:CHEMBL230686ALISERTIBVODOBATINIBXL228DASATINIB ANHYDROUSANLOTINIBGW441756XTIRBANIBULINMASITINIBGW459057ALINIFANIBSARACATINIBCINNAMTANNIN B1DOXORUBICIN HYDROCHLORIDEILORASERTIBNVP-TAE684HERBIMYCIN AMLN-8054XL999ENMD-981693ALSTERPAULLONEPP2CP-547632PONATINIBXL-228DOVITINIBLAVENDUSTIN AHESPERADINENMD-2076INTERLEUKIN-11VANDETANIBRG-1530TAMATINIBPD173074KENPAULLONEJNJ-26483327GW843682X-AZM 475271.00ENTRECTINIBCRENOLANIBGW559768XTOZASERTIBCYC-116AZD-0424PF-562271CENISERTIBPD-0166285CHEMBL:CHEMBL219557
Interaction Protein (29)
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 31718609 | Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis. | No abstract available |