Protein detail

SRC

Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Protein symbol
SRC
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
Protein classification
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Entrez Gene Symbol
Gene Synonym
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

128 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
SRCCDK8P49336S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK11BP21127S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK19Q9BWU1S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK9P50750S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK13Q14004S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK12Q9NYV4S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK16Q00536S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK17Q00537S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK18Q07002S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SRCCDK20Q8IZL9S75phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
Page 7 of 13PreviousNext

Ligand-Receptor Signaling

13 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_adhesioncell_adhesionCellinkerYesYesNoNoNo
adhesionadhesionOmniPathYesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
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Regulatory Interaction Network

362 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
SMOQ99835SRCP12931YesYesNoSIGNORSIGNOR:18455992
SRCP12931COMPLEX:O14920_O15111_Q9Y6K9YesYesNoSIGNORSIGNOR:12707358SIGNOR:12645577
SRCP12931ANXA1P04083YesYesNophosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperNetworKIN_KEAKEA:2457390SIGNOR:24103589ProtMapper:24103589phosphoELM:2457390ProtMapper:2457390KEA:17570479HPRD:2457390
SRCP12931WWOXQ9NZC7YesYesNoSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapperSIGNOR:15070730PhosphoSite:25650666PhosphoSite:27845895ProtMapper:30700826PhosphoSite:16288044PhosphoSite:32185845PhosphoSite:18371080PhosphoSite:15070730PhosphoSite:27551439PhosphoSite:15664696PhosphoSite:12514174KEA:15070730PhosphoSite:16115915PhosphoSite:31752354HPRD-phos:15070730PhosphoSite:19366691HPRD:15070730ProtMapper:15070730PhosphoSite:26120275PhosphoSite:31315632ProtMapper:25441426
SRCP12931RUNX3Q13761YesNoYesInnateDBSIGNORInnateDB:20100835SIGNOR:20100835
SRCP12931NECT2Q92692YesNoNoSIGNORProtMapperphosphoELM_KEAKEASIGNOR_ProtMapperKEA:10962558SIGNOR:10962558ProtMapper:10962558
SRCP12931LRP1Q07954YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALi2012HPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteAdhesomeHPRD-phosPhosphoSite:21650223HPRD-phos:11854294SIGNOR:18381291ProtMapper:11854294KEA:11854294PhosphoSite:11854294SIGNOR:12789267phosphoELM:12789267HPRD:11854294KEA:12789267Adhesome:11854294PhosphoSite:18381291ProtMapper:12789267HPRD:12789267ProtMapper:18381291Adhesome:12789267HPRD-phos:12789267
SRCP12931HXK2P52789YesYesNoSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:28054552PhosphoSite:28054552ProtMapper:28054552
SRCP12931PTN6P29350YesYesYesHPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAInnateDBLi2012HPRDKinexus_KEAWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDphosphoELMSIGNOR_ProtMapperPhosphoSiteAdhesomeHINT:14699166PhosphoSite:14699166PhosphoSite:25535246Adhesome:9261115InnateDB:9261115KEA:8692915SIGNOR:14699166BioGRID:14699166HPRD:8647855HPRD:12468645ProtMapper:15212693HPRD:9261115PhosphoSite:10488096PhosphoSite:14551136PhosphoSite:8114715KEA:8114715PhosphoSite:17675340PhosphoSite:7512963KEA:10574931KEA:14699166PhosphoSite:16649996HINT:10871605PhosphoSite:12468540KEA:14757045KEA:7512963KEA:12468540ProtMapper:14699166PhosphoSite:34010642phosphoELM:14699166KEA:10488096
PTN6P29350SRCP12931YesYesYesWangAdhesomeSIGNORProtMapperDEPODHPRDHINTBioGRIDInnateDBSIGNOR_ProtMapperHPRD-phosHPRD:8647855HPRD:12468645HPRD:9261115HINT:14699166ProtMapper:17974954HPRD-phos:8647855DEPOD:9261115Adhesome:9261115HPRD-phos:12468645InnateDB:9261115SIGNOR:9261115HPRD-phos:9261115ProtMapper:9261115BioGRID:14699166SIGNOR:17974954HINT:10871605
Page 19 of 37PreviousNext

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blottingFlow cytometry3315085003279541440091455
Sequence, Structure & Domains

Sequences

Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)

3D Structural Models

Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)

Domain & Motif Annotations

Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid