Protein detail
SRC
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein symbol SRC | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters |
Basic Information
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0002102 podosome
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005743 mitochondrial inner membrane
- GO:0005764 lysosome
- GO:0005770 late endosome
- GO:0005829 cytosol
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0005925 focal adhesion
- GO:0030054 cell junction
- GO:0032587 ruffle membrane
- GO:0043025 neuronal cell body
- GO:0044294 dendritic growth cone
- GO:0045121 membrane raft
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0097060 synaptic membrane
- GO:0098978 glutamatergic synapse
- GO:0099091 postsynaptic specialization, intracellular component
- GO:1902737 dendritic filopodium
Molecular Function
- GO:0004672 protein kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005102 signaling receptor binding
- GO:0005158 insulin receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016004 phospholipase activator activity
- GO:0019899 enzyme binding
- GO:0020037 heme binding
- GO:0030331 nuclear estrogen receptor binding
- GO:0042169 SH2 domain binding
- GO:0043274 phospholipase binding
- GO:0044325 transmembrane transporter binding
- GO:0045296 cadherin binding
- GO:0046875 ephrin receptor binding
- GO:0051117 ATPase binding
- GO:0051219 phosphoprotein binding
- GO:0070700 BMP receptor binding
- GO:0071253 connexin binding
- GO:0097110 scaffold protein binding
Biological Process
KEGG
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa01522 Endocrine resistance
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04137 Mitophagy - animal
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04370 VEGF signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04530 Tight junction
- KEGG:hsa04540 Gap junction
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04625 C-type lectin receptor signaling pathway
- KEGG:hsa04727 GABAergic synapse
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04915 Estrogen signaling pathway
- KEGG:hsa04917 Prolactin signaling pathway
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa05100 Bacterial invasion of epithelial cells
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05203 Viral carcinogenesis
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05207 Chemical carcinogenesis - receptor activation
- KEGG:hsa05208 Chemical carcinogenesis - reactive oxygen species
- KEGG:hsa05219 Bladder cancer
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-9032500 activated ntrk2 signals through fyn
- R-hsa-9603381 activated ntrk3 signals through pi3k
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-9612973 autophagy
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1500931 cell cell communication
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-446728 cell junction organization
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-5607764 clec7a dectin 1 signaling
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-389513 co inhibition by ctla4
- R-hsa-389356 co stimulation by cd28
- R-hsa-69231 cyclin d associated events in g1
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-418885 dcc mediated attractive signaling
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-1253288 downregulation of erbb4 signaling
- R-hsa-186763 downstream signal transduction
- R-hsa-3928663 epha mediated growth cone collapse
- R-hsa-3928662 ephb mediated forward signaling
- R-hsa-3928664 ephrin signaling
- R-hsa-3928665 eph ephrin mediated repulsion of cells
- R-hsa-2682334 eph ephrin signaling
- R-hsa-8939211 esr mediated signaling
- R-hsa-9009391 extra nuclear estrogen signaling
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-180292 gab1 signalosome
- R-hsa-157858 gap junction trafficking and regulation
- R-hsa-430116 gp1b ix v activation signalling
- R-hsa-9634597 gper1 signaling
- R-hsa-354194 grb2 sos provides linkage to mapk signaling for integrins
- R-hsa-418594 g alpha i signalling events
- R-hsa-418555 g alpha s signalling events
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-8876493 inla mediated entry of listeria monocytogenes into host cells
- R-hsa-168249 innate immune system
- R-hsa-354192 integrin signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-373760 l1cam interactions
- R-hsa-9658195 leishmania infection
- R-hsa-8876384 listeria monocytogenes entry into host cells
- R-hsa-9620244 long term potentiation
- R-hsa-5674135 map2k and mapk activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-199991 membrane trafficking
- R-hsa-8874081 met activates ptk2 signaling
- R-hsa-8875878 met promotes cell motility
- R-hsa-5205647 mitophagy
- R-hsa-453279 mitotic g1 phase and g1 s transition
- R-hsa-375165 ncam signaling for neurite out growth
- R-hsa-5654726 negative regulation of fgfr1 signaling
- R-hsa-5654727 negative regulation of fgfr2 signaling
- R-hsa-5654732 negative regulation of fgfr3 signaling
- R-hsa-5654733 negative regulation of fgfr4 signaling
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-9675108 nervous system development
- R-hsa-373752 netrin 1 signaling
- R-hsa-418886 netrin mediated repulsion signals
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-1251985 nuclear signaling by erbb4
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-372708 p130cas linkage to mapk signaling for integrins
- R-hsa-171007 p38mapk events
- R-hsa-9664407 parasite infection
- R-hsa-210990 pecam1 interactions
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76009 platelet aggregation plug formation
- R-hsa-5673000 raf activation
- R-hsa-8934903 receptor mediated mitophagy
- R-hsa-437239 recycling pathway of l1
- R-hsa-9764561 regulation of cdh1 function
- R-hsa-428542 regulation of commissural axon pathfinding by slit and robo
- R-hsa-9759476 regulation of homotypic cell cell adhesion
- R-hsa-1433559 regulation of kit signaling
- R-hsa-8934593 regulation of runx1 expression and activity
- R-hsa-8941858 regulation of runx3 expression and activity
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-8853659 ret signaling
- R-hsa-9013420 rhou gtpase cycle
- R-hsa-5663220 rho gtpases activate formins
- R-hsa-9012999 rho gtpase cycle
- R-hsa-195258 rho gtpase effectors
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-8941326 runx2 regulates bone development
- R-hsa-8940973 runx2 regulates osteoblast differentiation
- R-hsa-9663891 selective autophagy
- R-hsa-201556 signaling by alk
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-9680350 signaling by csf1 m csf in myeloid cells
- R-hsa-177929 signaling by egfr
- R-hsa-1227986 signaling by erbb2
- R-hsa-1236394 signaling by erbb4
- R-hsa-190236 signaling by fgfr
- R-hsa-5654736 signaling by fgfr1
- R-hsa-5654738 signaling by fgfr2
- R-hsa-5654741 signaling by fgfr3
- R-hsa-5654743 signaling by fgfr4
- R-hsa-372790 signaling by gpcr
- R-hsa-9669938 signaling by kit in disease
- R-hsa-6806834 signaling by met
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
- R-hsa-9006115 signaling by ntrk2 trkb
- R-hsa-9034015 signaling by ntrk3 trkc
- R-hsa-166520 signaling by ntrks
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-186797 signaling by pdgf
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-376176 signaling by robo receptors
- R-hsa-1433557 signaling by scf kit
- R-hsa-194138 signaling by vegf
- R-hsa-187687 signalling to erks
- R-hsa-167044 signalling to ras
- R-hsa-392518 signal amplification
- R-hsa-391160 signal regulatory protein family interactions
- R-hsa-1295596 spry regulation of fgf signaling
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
- R-hsa-8878171 transcriptional regulation by runx1
- R-hsa-8878166 transcriptional regulation by runx2
- R-hsa-8878159 transcriptional regulation by runx3
- R-hsa-112315 transmission across chemical synapses
- R-hsa-5218921 vegfr2 mediated cell proliferation
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
128 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SRC | PIK3CG | P48736 | S | 70 | phosphorylation | REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:27169346 |
| SRC | CHEK1 | O14757 | S | 51 | phosphorylation | PhosphoSiteSparser_ProtMapperProtMapper | ProtMapper:29954829 |
| SRC | CHEK1 | O14757 | Y | 530 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| SRC | CHEK1 | O14757 | Y | 419 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| SRC | EPHB2 | P29323 | Y | 419 | phosphorylation | PhosphoSite | |
| SRC | GSK3B | P49841 | S | 51 | phosphorylation | PhosphoSite | |
| SRC | GSK3B | P49841 | S | 43 | phosphorylation | PhosphoSite | |
| SRC | GSK3B | P49841 | S | 493 | phosphorylation | PhosphoSite | |
| SRC | GSK3B | P49841 | Y | 419 | phosphorylation | PhosphoSite | |
| SRC | AXL | P30530 | Y | 419 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
362 records.
Protein Complex Composition
48 records.
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Sequence, Structure & Domains
Sequences
Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)
3D Structural Models
Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)
Domain & Motif Annotations
Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases
Acute myeloid leukaemiaBCR-ABL1-negative chronic myeloid leukaemiaBrain cancerBreast cancerCardiovascular diseaseCervical cancerChronic obstructive pulmonary diseaseEndometrial cancerEpidermal dysplasiasFallopian tube cancerGastrointestinal stromal tumourGram-positive bacterial infectionIschemiaLeiomyosarcomaLow bone mass disorderMalignant digestive organ neoplasmMalignant haematopoietic neoplasmMature B-cell leukaemiaMetastatic digestive system neoplasmMotor neuron diseaseMultiple myelomaMultiple sclerosisMyeloproliferative neoplasmNasopharyngeal cancerOsteosarcomaOvarian cancerPancreatic cancerParkinsonismPeritoneal cancerPostoperative inflammationSarcomaSolid tumour/cancerSynovial sarcoma
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Drugs
CEDIRANIBCLOZAPINEBOSUTINIBNULLTG100-801TYRPHOSTIN A9KX2-361CHEMBL:CHEMBL230686ALISERTIBVODOBATINIBXL228DASATINIB ANHYDROUSANLOTINIBGW441756XTIRBANIBULINMASITINIBGW459057ALINIFANIBSARACATINIBCINNAMTANNIN B1DOXORUBICIN HYDROCHLORIDEILORASERTIBNVP-TAE684HERBIMYCIN AMLN-8054XL999ENMD-981693ALSTERPAULLONEPP2CP-547632PONATINIBXL-228DOVITINIBLAVENDUSTIN AHESPERADINENMD-2076INTERLEUKIN-11VANDETANIBRG-1530TAMATINIBPD173074KENPAULLONEJNJ-26483327GW843682X-AZM 475271.00ENTRECTINIBCRENOLANIBGW559768XTOZASERTIBCYC-116AZD-0424PF-562271CENISERTIBPD-0166285CHEMBL:CHEMBL219557
Interaction Protein
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid