Protein detail
SRC
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Entry name SRC | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class (8)
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function (9)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway7
Protein Function (9)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (23)
- GO:0002102 podosome
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005743 mitochondrial inner membrane
- GO:0005764 lysosome
- GO:0005770 late endosome
- GO:0005829 cytosol
- GO:0005884 actin filament
- GO:0005886 plasma membrane
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Molecular Function (23)
- GO:0004672 protein kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005102 signaling receptor binding
- GO:0005158 insulin receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016004 phospholipase activator activity
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Biological Process (3)
KEGG (45)
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa01522 Endocrine resistance
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04137 Mitophagy - animal
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04370 VEGF signaling pathway
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Reactome (136)
- R-hsa-9032500 activated ntrk2 signals through fyn
- R-hsa-9603381 activated ntrk3 signals through pi3k
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-9612973 autophagy
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1500931 cell cell communication
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Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence552
Enzyme-Mediated Modification (128)
128 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SRC | PRKX | P51817 | S | 17 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SRC | PRKY | O43930 | S | 17 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SRC | CDK1 | P06493 | S | 75 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperREACH_ProtMapper | ProtMapper:12801906 |
| SRC | CDK1 | P06493 | Y | 530 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21442024 |
| SRC | CDK2 | P24941 | S | 75 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SRC | CDK3 | Q00526 | S | 75 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SRC | CDK10 | Q15131 | S | 75 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SRC | CDK4 | P11802 | S | 75 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SRC | CDK6 | Q00534 | S | 75 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SRC | CDK7 | P50613 | S | 75 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network (362)
362 records.
Protein Complex Composition (48)
48 records.
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Sequence, Structure & Domains15
Sequences
Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)
3D Structural Models
Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)
Domain & Motif Annotations
Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance9
Disease Involvement (4)
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases (33)
Acute myeloid leukaemiaBCR-ABL1-negative chronic myeloid leukaemiaBrain cancerBreast cancerCardiovascular diseaseCervical cancerChronic obstructive pulmonary diseaseEndometrial cancerEpidermal dysplasiasFallopian tube cancerGastrointestinal stromal tumourGram-positive bacterial infectionIschemiaLeiomyosarcomaLow bone mass disorderMalignant digestive organ neoplasmMalignant haematopoietic neoplasmMature B-cell leukaemiaMetastatic digestive system neoplasmMotor neuron diseaseMultiple myelomaMultiple sclerosisMyeloproliferative neoplasmNasopharyngeal cancerOsteosarcomaOvarian cancerPancreatic cancerParkinsonismPeritoneal cancerPostoperative inflammationSarcomaSolid tumour/cancerSynovial sarcoma
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Drugs (55)
CEDIRANIBCLOZAPINEBOSUTINIBNULLTG100-801TYRPHOSTIN A9KX2-361CHEMBL:CHEMBL230686ALISERTIBVODOBATINIBXL228DASATINIB ANHYDROUSANLOTINIBGW441756XTIRBANIBULINMASITINIBGW459057ALINIFANIBSARACATINIBCINNAMTANNIN B1DOXORUBICIN HYDROCHLORIDEILORASERTIBNVP-TAE684HERBIMYCIN AMLN-8054XL999ENMD-981693ALSTERPAULLONEPP2CP-547632PONATINIBXL-228DOVITINIBLAVENDUSTIN AHESPERADINENMD-2076INTERLEUKIN-11VANDETANIBRG-1530TAMATINIBPD173074KENPAULLONEJNJ-26483327GW843682X-AZM 475271.00ENTRECTINIBCRENOLANIBGW559768XTOZASERTIBCYC-116AZD-0424PF-562271CENISERTIBPD-0166285CHEMBL:CHEMBL219557
Interaction Protein (29)
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 31718609 | Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis. | No abstract available |