Protein detail

SRC

Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Protein symbol
SRC
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
Protein classification
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Basic Information
Protein Names
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Entrez Gene Symbol
Gene Synonym
ASVc-srcSRC1
Gene Description
SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome
20
Position
37344685-37406050
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverBrain Regional SpecificmidbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

128 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
SRCCDK5Q00535S75phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperdbPTM:17192257ProtMapper:29196663dbPTM:21442427KEA:10544291dbPTM:18691976ProtMapper:21442427dbPTM:19369195HPRD:18691976HPRD:10544291ProtMapper:10544291phosphoELM:10544291KEA:17192257HPRD:19415658ProtMapper:12801906SIGNOR:10544291
SRCCDK5Q00535T37phosphorylationPhosphoNetworks
SRCCDK5Q00535S306phosphorylationPhosphoNetworks
SRCCSKP41240Y530phosphorylationPhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPProtMapperRLIMS-P_ProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:21940449KEA:3103926ProtMapper:23159740ProtMapper:23824743ProtMapper:1383688dbPTM:19534553ProtMapper:22689825ProtMapper:20337577KEA:12387813ProtMapper:16227616ProtMapper:24632723ProtMapper:21442427dbPTM:19369195ProtMapper:28974561ProtMapper:9523754ProtMapper:21632985phosphoELM:12468645KEA:7678701ProtMapper:26453921dbPTM:7525268ProtMapper:20525307ProtMapper:20657842ProtMapper:25372749ProtMapper:23051580KEA:9208935ProtMapper:18614016ProtMapper:22323292ProtMapper:26234813KEA:12468645ProtMapper:23378895ProtMapper:7592628
SRCCSKP41240Y419phosphorylationNCI-PID_ProtMapperProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:16537894ProtMapper:11489946ProtMapper:24632723ProtMapper:14967142
SRCCSKP41240Y338phosphorylationPhosphoNetworks
SRCPRKCAP17252S12phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperSIGNOR:2996780ProtMapper:2996780KEA:2996780KEA:2136766HPRD:2996780
SRCPTPN1P18031Y419dephosphorylationHPRDSIGNORDEPODDEPOD:11007774HPRD:9261115DEPOD:17974954DEPOD:16115959SIGNOR:11007774HPRD:11007774DEPOD:15866871
SRCPTPN1P18031Y530dephosphorylationHPRDDEPODHPRD:8647855HPRD:12468645DEPOD:11007774HPRD:9261115DEPOD:17974954DEPOD:16115959HPRD:11007774DEPOD:15866871
SRCPTPN1P18031Y419phosphorylationNCI-PID_ProtMapperSIGNOR_ProtMapperProtMapperProtMapper:15866871ProtMapper:11007774ProtMapper:11346638
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Ligand-Receptor Signaling

13 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_adhesioncell_adhesionCellinkerYesYesNoNoNo
adhesionadhesionOmniPathYesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
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Regulatory Interaction Network

362 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
SRCP12931GRIK2Q13002YesYesNoiPTMnetPhosphoSite_norefSIGNORProtMapperPhosphoSite_ProtMapperSIGNOR:25201974
SRCP12931ARAFP10398YesYesNophosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperReactome_ProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:9020159SIGNOR:9020159PhosphoSite:9020159phosphoELM:9020159ProtMapper:9020159
SRCP12931NEMOQ9Y6K9YesNoYesiPTMnetPhosphoPointSIGNORProtMapperHPRDSPIKE_LCREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:23131831HPRD:15749833SPIKE_LC:17145710ProtMapper:23131831SIGNOR:23131831
SRCP12931STA5AP42229YesYesNoHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEANCI-PID_ProtMapperHPRDCui2007CancerCellMapWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperNetPathSPIKE_LCProtMapper:15702476KEA:11641791ProtMapper:15212693NetPath:10358079KEA:8617237phosphoELM:11641791KEA:7925280HPRD:10358079SIGNOR:11641791KEA:17081983SPIKE_LC:16189514ProtMapper:22090359KEA:11413148ProtMapper:31752278ProtMapper:11641791CancerCellMap:10358079
SRCP12931HIPK2Q9H2X6YesYesNoiPTMnetSIGNORProtMapperCui2007WangPhosphoSite_ProtMapperSIGNOR:24196445
SRCP12931RASKP01116YesYesNoSparser_ProtMapperKEGG-MEDICUSPhosphoSite_norefSIGNORProtMapperWangREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:26854235ProtMapper:34725361SIGNOR:34725361PhosphoSite:34725361PhosphoSite:30644389SIGNOR:9096340
SRCP12931SHC3Q92529YesYesNoMIMPiPTMnetSIGNORPhosphoSite_MIMPSIGNOR:11791173
SRCP12931BMXP51813YesYesNoHPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperNetworKIN_KEABEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSPIKE_LCKEA:10688651dbPTM:10688651ProtMapper:10688651PhosphoSite:10688651SIGNOR:10688651PhosphoSite:27601470KEA:17570479HPRD:10688651phosphoELM:10688651SPIKE_LC:16189514
SRCP12931ITB2P05107YesYesYesWangSIGNORSIGNOR:25624455
SRCP12931FHL1Q13642YesYesNoSparser_ProtMapperPhosphoSite_norefSIGNORProtMapperREACH_ProtMapperPhosphoSiteProtMapper:29434030SIGNOR:29434030PhosphoSite:29434030
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Protein Complex Composition

48 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
DMAP1ACTBACTL6ABRD8DMAP1EP400EPC1ING3MEAF6RUVBL1RUVBL2SRCAPTRRAPVPS72YEATS4O95619O96019P60709Q15906Q6ZRS2Q96L91Q9H0E9Q9H2F5Q9HAF1Q9NPF5Q9NXR8Q9Y230Q9Y265Q9Y4A51:1:1:1:1:1:1:1:1:1:1:1:1:1CompleatCompleat:HC147414966270
DMAP1-associated complexACTL6ABRD8DMAP1EP400EPC1RUVBL1RUVBL2SRCAPTRRAPVPS72O96019Q15906Q6ZRS2Q96L91Q9H0E9Q9H2F5Q9NPF5Q9Y230Q9Y265Q9Y4A51:1:1:1:1:1:1:1:1:1CompleatCORUMCompleat:HC2807CORUM:79914966270
HT_DM_Cluster34ATP6V1B1ATP6V1B2PCYT1APCYT1BPDSS2RSRC2SLC25A32WIF1P15313P21281P49585Q7L4I2Q86YH6Q9H2D1Q9Y5K3Q9Y5W51:1:1:1:1:1:1:1CompleatCompleat:HC97722036573
MASH1 promoter-coactivator complexCREBBPH3-3AH3C11H3C15H4C4HES1KAT2BNONOPARP1POLR2ASRCP09874P12931P24928P62805P68431P84243Q14469Q15233Q71DI3Q92793Q928311:1:1:1:1:1:1:1:1:1:1CompleatCompleat:HC333515607978
MASH1 promoter-coactivator complexCREBBPH3C11H4C4HES1KAT2BNONOPARP1POLR2ASRCP09874P12931P24928P62805P68431Q14469Q15233Q92793Q928310:0:0:0:0:0:0:0:0CORUMCORUM:313715607978
N-CoR-1NCOR1SAP130SF3A1SMARCA4SMARCB1SMARCC1SMARCC2SRCAPTRIM28O75376P51532Q12824Q13263Q15459Q6ZRS2Q8TAQ2Q92922Q9H0E31:1:1:1:1:1:1:1:1CompleatCompleat:HC120111013263
NCOR1 complexHDAC3NCOR1SF3A1SF3B3SMARCA4SMARCB1SMARCC1SMARCC2SRCAPTRIM28O15379O75376P51532Q12824Q13263Q15393Q15459Q6ZRS2Q8TAQ2Q929221:1:1:1:1:1:1:1:1:1CompleatCORUMCompleat:HC1321CORUM:141311013263
SH3P2/OSTF1-CBL-SRC complexCBLOSTF1SRCP12931P22681Q928821:1:1CompleatCORUMCORUM:5713Compleat:HC98015135048
SRC-PRKCD-CDCP1 complexCDCP1PRKCDSRCP12931Q05655Q9H5V81:1:1CompleatCORUMCORUM:2471Compleat:HC221215851033
Src-dynamin-synapsin complexDNM1DNM2SRCSYN1SYN2P12931P17600P50570Q05193Q927771:1:1:1:1CompleatCompleat:HC12579539797
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Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blottingFlow cytometry3315085003279541440091455
Sequence, Structure & Domains

Sequences

Length
536
Mass
59,835
Sequence
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=c-src; IsoId=P12931-1; Sequence=Displayed; Name=2; Synonyms=c-srcN1, N1-Src; IsoId=P12931-2; Sequence=VSP_012134; Name=3; Synonyms=c-srcN2, N2-Src; IsoId=P12931-3; Sequence=VSP_061494
Alternative Sequence
117; T -> TRKVDVR (in isoform 2); 117; T -> TRKVDVSQTWFTFRWLQR (in isoform 3)

3D Structural Models

Turn
127..129; 196..198; 290..292; 302..304; 423..426; 460..462; 521..523
Helix
137..139; 146..148; 158..165; 226..233; 267..269; 307..319; 349..353; 355..358; 363..382; 392..394; 399..401; 410..413; 417..420; 429..431; 434..439; 444..459; 471..479; 492..501; 506..508; 512..520
Beta Strand
87..93; 99..102; 110..114; 118..126; 132..136; 140..142; 152..154; 167..170; 174..179; 181..183; 187..195; 199..209; 211..213; 215..218; 221..225; 240..242; 256..259; 270..278; 280..282; 283..289; 293..299; 328..332; 334..336; 338..341; 345..348; 395..397; 403..405
3D Structure
NMR spectroscopy (2); X-ray crystallography (74)

Domain & Motif Annotations

Compositional Bias
7..19; Basic and acidic residues
Domain (CC)
The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Domain (FT)
84..145; SH3; 151..248; SH2; 270..523; Protein kinase
Region
1..53; Disordered
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Biomarker
Phase 2; Phase 1; Approved; Phase 1/2; Phase 3; Investigative; Terminated
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000010810ENSG00000039068ENSG00000050820ENSG00000072201ENSG00000080824ENSG00000101266ENSG00000105401ENSG00000105976ENSG00000110395ENSG00000121774ENSG00000128052ENSG00000132670ENSG00000136932ENSG00000137486ENSG00000141480ENSG00000141736ENSG00000143537ENSG00000145675ENSG00000146648ENSG00000153317ENSG00000169398ENSG00000170248ENSG00000174775ENSG00000185499ENSG00000196396ENSG00000241794ENSG00000254087ENSG00000261371ENSG00000269335
Interaction Count
29
Interaction Dataset
intact_biogrid