Protein detail

LAMP2

Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)

Entry name LAMP2	UniProt ID P13473	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification CD markersDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)

Protein Class (7)

CD markersDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (6)

Transporters
CD markers
Potential drug targets
Human disease related genes:Musculoskeletal diseases:Muscular diseases
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Lysosomal storage diseases

Transmembrane

376..399; Helical

Transmembrane Count

Ensembl

ENSG00000005893

Entrez Gene Symbol

LAMP2

Gene Synonym

CD107b

Gene Description

Lysosomal associated membrane protein 2

Chromosome

Position

120426148-120469365

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function (6)

Transporters
CD markers
Potential drug targets
Human disease related genes:Musculoskeletal diseases:Muscular diseases
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Lysosomal storage diseases

Cellular Component (20)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

KEGG (6)

Reactome (7)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence36

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LAMP2	MAPK14	Q16539	T	213	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LAMP2	MAPK14	Q16539	T	211	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (27)

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
	COMPLEX:P62877_P63208_Q13616	LAMP2	P13473	Yes	No	Yes	SIGNOR	SIGNOR:28743755
FBX27	Q8NI29	LAMP2	P13473	Yes	No	Yes	SIGNOR	SIGNOR:28743755
MK14	Q16539	LAMP2	P13473	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:29176575

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BCAS2 CDC5L EFTUD2 ISY1 LAMP2 PATL1 PHF5A PLRG1 PRPF19 PRPF3 PRPF31 PRPF4 PRPF6 PRPF8 SART1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SNRNP200 SNRNP70 SNRPA SNRPA1 SNRPB2 SNRPD1 SNRPD2 SNRPD3 SRSF1 SUB1 TRIO U2AF1 U2AF2 XAB2	O43172 O43290 O43395 O43660 O75533 O75643 O75934 O75962 O94906 P08579 P08621 P09012 P09661 P13473 P26368 P53999 P62314 P62316 P62318 Q01081 Q07955 Q12874 Q13435 Q15029 Q15393 Q15427 Q15428 Q15459 Q6P2Q9 Q7RTV0 Q86TB9 Q8WWY3 Q99459 Q9BWJ5 Q9HCS7 Q9ULR0 Q9UMS4 Q9Y3B4	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_618
LAMP2 PCNA PDS5B RFC1 RFC4 SUB1	P12004 P13473 P35249 P35251 P53999 Q9NTI5	0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_518
LAMP2	P13473	3	PDB	PDB:2mom

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains12

Sequences

Length

410

Mass

44,961

Sequence

MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKTYKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNTGDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNGTVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQLNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVNISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQGKYSTAQDCSADDDNFLVPIAVGAALAGVLILVLLAYFIGLKHHHAGYEQF

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=LAMP-2A; IsoId=P13473-1; Sequence=Displayed; Name=LAMP-2B; IsoId=P13473-2; Sequence=VSP_003044; Name=LAMP-2C; IsoId=P13473-3; Sequence=VSP_042519

Alternative Sequence

366..410; QDCSADDDNFLVPIAVGAALAGVLILVLLAYFIGLKHHHAGYEQF -> EECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV (in isoform LAMP-2C); 367..410; DCSADDDNFLVPIAVGAALAGVLILVLLAYFIGLKHHHAGYEQF -> ECSLDDDTILIPIIVGAGLSGLIIVIVIAYVIGRRKSYAGYQTL (in isoform LAMP-2B)

3D Structural Models

Helix

380..400

Beta Strand

374..377

3D Structure

NMR spectroscopy (2)

Domain & Motif Annotations

Compositional Bias

199..213; Low complexity

Region

29..192; First lumenal domain; 193..228; Hinge; 199..221; Disordered; 229..375; Second lumenal domain; 401..404; Important for binding and subsequent lysosomal degradation of target proteins

Protein Families

LAMP family

Sequence Similarities

Belongs to the LAMP family.

Clinical Relevance7

Disease Involvement (2)

Disease variantGlycogen storage disease

Related Diseases

Inborn carbohydrate metabolism error

Biomarker

Phase 1

Antibody (2)

CAB005272 HPA029100

Interaction Protein (3)

ENSG00000127022ENSG00000149357ENSG00000170088

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available
38071653	Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis.	No abstract available