Protein detail
ICAM2
Intercellular adhesion molecule 2 (ICAM-2) (CD antigen CD102)
Entry name ICAM2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Intercellular adhesion molecule 2 (ICAM-2) (CD antigen CD102)
Protein Class (4)
CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Transmembrane
224..248; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD102
Gene Description
Intercellular adhesion molecule 2
Chromosome
17
Position
64002594-64020634
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization6
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificBergmann gliaBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway7
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function
Biological Process (3)
KEGG (4)
Reactome (7)
- R-hsa-1280218 adaptive immune system
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-1474244 extracellular matrix organization
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-168249 innate immune system
- R-hsa-216083 integrin cell surface interactions
Mediation Categories
Immune mediation
Relations & Evidence52
Ligand-Receptor Signaling (47)
47 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster383 | RBSNTICAM2TMED3TMED7 | Q86XR7Q9H1K0Q9Y3B3Q9Y3Q3 | 2:1:1:1 | Compleat | Compleat:HC1634 | 22036573 |
| TICAM2TMED1TMED10TMED2TMED3TMED4TMED5TMED9 | P49755Q13445Q15363Q7Z7H5Q86XR7Q9BVK6Q9Y3A6Q9Y3Q3 | 0:0:0:0:0:0:0:0 | hu.MAP | |||
| GOLGA2GORASP1TICAM2 | Q08379Q86XR7Q9BQQ3 | 0:0:0 | hu.MAP | |||
| TICAM2 | Q86XR7 | 5 | PDB | PDB:9dlg |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometryWestern blottingR SequencingFlow cytometryMORPH | 13 | 32295833322958334121688434401050399494903873186824505114322958333246803336635400315882383813660130451371 |
Sequence, Structure & Domains10
Sequences
Length
275
Mass
30,654
Sequence
MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP
3D Structural Models
Helix
142..144; 181..185; 197..199
Beta Strand
29..38; 42..51; 56..61; 63..72; 75..83; 87..95; 98..108; 116..125; 128..136; 145..151; 154..160; 171..178; 188..195; 203..207; 214..216
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
41..98; Ig-like C2-type 1; 127..197; Ig-like C2-type 2
Region
251..275; Required for interaction with EZR, MSN and RDX and co-localization to microvilli
Protein Families (2)
- Immunoglobulin superfamily
- ICAM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Clinical Relevance2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40689422 | Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles. | No abstract available |