Protein detail
ITA4
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Entry name ITA4 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
978..1001; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificSertoli cells
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0008305 integrin complex
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0030426 growth cone
- GO:0034668 integrin alpha4-beta1 complex
- GO:0034669 integrin alpha4-beta7 complex
- GO:0043025 neuronal cell body
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
KEGG
- hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04672 Intestinal immune network for IgA production
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-216083 integrin cell surface interactions
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-8949275 runx3 regulates immune response and cell migration
- R-hsa-9679506 sars cov infections
- R-hsa-8878159 transcriptional regulation by runx3
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGA4 | PRKACA | P17612 | S | 1,021 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:18707149HPRD:18578522HPRD:11533025ProtMapper:11533025SIGNOR:11533025KEA:11533025HPRD:20166139 |
| ITGA4 | PRKX | P51817 | S | 1,021 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ITGA4 | PRKY | O43930 | S | 1,021 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ITGA4 | RPS6KA3 | P51812 | S | 1,027 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| growth_factor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | ITA4 | P13612 | Yes | Yes | No | WangphosphoELM_MIMPAdhesomeMIMPPhosphoSite_MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | HPRD:11533025HPRD-phos:11533025PhosphoSite:19401330ProtMapper:18707149SIGNOR:11533025PhosphoSite:12837751PhosphoSite:21224395PhosphoSite:11533025HPRD-phos:18578522KEA:11533025ProtMapper:11533025PhosphoSite:18583710Adhesome:11533025HPRD-phos:18707149PhosphoSite:23979717ProtMapper:18578522PhosphoSite:31562188ProtMapper:20166139PhosphoSite:17603879HPRD-phos:20166139 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
1,032
Mass
114,900
Sequence
MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13612-1; Sequence=Displayed; Name=2; IsoId=P13612-2; Sequence=VSP_056612, VSP_056613
Alternative Sequence
186..195; DYVKKFGENF -> GSISKYRART (in isoform 2); 196..1032; Missing (in isoform 2)
3D Structural Models
Turn
152..156; 193..197; 230..233
Helix
174..176; 218..221; 275..277; 393..396; 420..422; 453..455
Beta Strand
42..45; 54..61; 64..71; 87..95; 102..104; 127..133; 141..145; 165..168; 178..180; 202..206; 208..215; 223..229; 234..237; 253..258; 267..272; 280..286; 288..298; 308..313; 318..320; 322..327; 332..334; 338..344; 346..349; 351..353; 381..383; 386..390; 398..403; 415..419; 429..438; 440..445; 447..452; 457..461; 466..474; 495..505; 511..522; 532..534; 536..538; 542..554; 556..564; 575..583; 610..617
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Repeat
35..100; FG-GAP 1; 110..177; FG-GAP 2; 185..237; FG-GAP 3; 238..291; FG-GAP 4; 292..351; FG-GAP 5; 355..412; FG-GAP 6; 416..478; FG-GAP 7
Motif
606..616; SG1; 1003..1007; GFFKR motif
Domain (CC)
The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Protein Families
Integrin alpha chain family
Sequence Similarities
Belongs to the integrin alpha chain family.
Clinical Relevance
Related Diseases
Biomarker
Phase 2; Approved; Phase 1
Interaction Protein
ENSG00000089159
Interaction Count
1
Interaction Dataset
intact_biogrid