Protein detail
AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)
Protein symbol AT1A3 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 10 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
78..98; Helical; 122..142; Helical; 279..298; Helical; 311..328; Helical; 763..782; Helical; 793..813; Helical; 834..856; Helical; 909..928; Helical; 942..960; Helical; 976..996; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
DYT12
Gene Description
ATPase Na+/K+ transporting subunit alpha 3
Chromosome
19
Position
41966582-41997497
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAdipocytesSingle-Nuclei Brain Specificcerebellar inhibitorySecretome LocationSecreted to extracellular matrixSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component
- GO:0001917 photoreceptor inner segment
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005890 sodium:potassium-exchanging ATPase complex
- GO:0016020 membrane
- GO:0030424 axon
- GO:0031090 organelle membrane
- GO:0032809 neuronal cell body membrane
- GO:0043025 neuronal cell body
- GO:0045202 synapse
- GO:0060342 photoreceptor inner segment membrane
- GO:0098984 neuron to neuron synapse
- GO:1903561 extracellular vesicle
Molecular Function
Biological Process
KEGG
- hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04260 Cardiac muscle contraction
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04918 Thyroid hormone synthesis
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04960 Aldosterone-regulated sodium reabsorption
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa04964 Proximal tubule bicarbonate reclamation
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa04972 Pancreatic secretion
- KEGG:hsa04973 Carbohydrate digestion and absorption
- KEGG:hsa04974 Protein digestion and absorption
- KEGG:hsa04976 Bile secretion
- KEGG:hsa04978 Mineral absorption
Reactome
- R-hsa-5576891 cardiac conduction
- R-hsa-5663205 infectious disease
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-397014 muscle contraction
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9679506 sars cov infections
- R-hsa-382551 transport of small molecules
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ATP1A3 | GAK | O14976 | T | 705 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:30623173 |
| ATP1A3 | AAK1 | Q2M2I8 | T | 705 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:30623173 |
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| sodium_potassium_atpase | transporter | HGNC | No | Yes | No | Yes | No |
| transporter | transporter | HGNC | No | Yes | No | Yes | No |
| p_atpase | transporter | Surfaceome | No | Yes | No | Yes | No |
| active | transporter | Surfaceome | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains
Sequences
Length
1,013
Mass
111,749
Sequence
MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P13637-1; Sequence=Displayed; Name=2; IsoId=P13637-2; Sequence=VSP_046956; Name=3; IsoId=P13637-3; Sequence=VSP_046957
Alternative Sequence
1..2; MG -> MGGWEEERNRRAT (in isoform 2); 1..2; MG -> MGSGGSDSYRIATSQ (in isoform 3)
3D Structural Models
Turn
49..51; 306..308; 432..434; 474..476; 537..539; 552..554; 725..727; 802..806; 819..822; 829..831; 844..846; 874..876
Helix
38..42; 43..45; 57..65; 80..86; 89..91; 92..106; 120..139; 142..148; 149..152; 172..174; 226..228; 273..303; 309..321; 326..343; 352..355; 367..371; 406..415; 441..451; 457..463; 501..507; 522..536; 589..598; 611..621; 631..638; 642..644; 647..649; 657..660; 665..674; 685..695; 696..698; 709..711; 712..717; 730..735; 746..771; 774..785; 794..801; 808..814; 837..843; 847..865; 870..872; 877..880; 898..926; 934..936; 942..958; 964..967; 975..979; 982..1001; 1006..1010
Beta Strand
34..36; 158..162; 167..171; 177..184; 190..198; 200..204; 207..209; 215..217; 230..233; 238..250; 254..256; 347..351; 356..359; 362..366; 377..383; 386..389; 403..405; 416..418; 428..430; 466..470; 482..484; 488..490; 493..495; 508..513; 516..519; 540..545; 548..550; 563..565; 573..575; 577..582; 602..606; 652..656; 676..682; 702..705; 718..724; 736..743; 930..932
3D Structure
Electron microscopy (5)
Domain & Motif Annotations
Region
1..24; Disordered; 72..74; Interaction with phosphoinositide-3 kinase
Protein Families
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IIC subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Clinical Relevance
Disease Involvement
DeafnessDisease variantDystoniaEpilepsyIntellectual disabilityParkinsonism
Drugs
Interaction Protein
ENSG00000018625ENSG00000069849ENSG00000163399
Interaction Count
3
Interaction Dataset
biogrid_bioplex