Protein detail
EF2
Elongation factor 2 (EF-2) (EC 3.6.5.-)
Entry name EF2 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 35 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Elongation factor 2 (EF-2) (EC 3.6.5.-)
Protein Class (8)
Cancer-related genesDisease related genesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Biotech drugs
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
EEF-2EF2
Gene Description
Eukaryotic translation elongation factor 2
Chromosome
19
Position
3976056-3985463
Supporting publications (n)
35
EVMP confidence score
0.88
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificAstrocytesSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component (13)
- GO:0005576 extracellular region
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005840 ribosome
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016235 aggresome
- GO:0034774 secretory granule lumen
- GO:0045202 synapse
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Molecular Function (8)
Biological Process (3)
Reactome (12)
- R-hsa-9824439 bacterial infection pathways
- R-hsa-156842 eukaryotic translation elongation
- R-hsa-163841 gamma carboxylation hypusinylation hydroxylation and arylsulfatase activation
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-6798695 neutrophil degranulation
- R-hsa-597592 post translational protein modification
- R-hsa-8876725 protein methylation
- R-hsa-5358493 synthesis of diphthamide eef2
- R-hsa-72766 translation
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Mediation Categories (3)
Clinical-translation mediationImmune mediationMetabolism mediation
Relations & Evidence51
Enzyme-Mediated Modification (23)
23 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EEF2 | CDK1 | P06493 | S | 595 | phosphorylation | PhosphoSite | |
| EEF2 | CDK1 | P06493 | S | 360 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:24958351 |
| EEF2 | CDK2 | P24941 | T | 435 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| EEF2 | CDK2 | P24941 | S | 595 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23184662ProtMapper:24958351ProtMapper:24167567 |
| EEF2 | NEK2 | P51955 | S | 595 | phosphorylation | PhosphoSite | |
| EEF2 | EGF | P01133 | T | 57 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| EEF2 | HTR2C | P28335 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:27821870 |
| EEF2 | TRPM7 | Q96QT4 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21112387 |
| EEF2 | PREP | P48147 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29371602 |
| EEF2 | NUP214 | P35658 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:18728285 |
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| receptor | receptor | scConnect | Yes |
Regulatory Interaction Network (5)
5 records.
Protein Complex Composition (14)
14 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster64 | EEF2FKBP1AFKBP1BGRHPRITPANPM1NPM2NPM3 | O75607P06748P13639P62942P68106Q86SE8Q9BY32Q9UBQ7 | 1:1:1:1:1:1:1:1 | Compleat | Compleat:HC2793 | 22036573 |
| HT_SC_Cluster231 | EEF2EIF4A1EIF4A2EIF4A3 | P13639P38919P60842Q14240 | 1:1:1:1 | Compleat | Compleat:HC1329 | |
| HT_SC_Cluster58 | DPH1DPH2DPH3EEF2HGH1SERGEF | P13639Q96FX2Q9BQC3Q9BTY7Q9BZG8Q9UGK8 | 1:1:1:1:1:1 | Compleat | Compleat:HC1661 | |
| EEF2KFKBP6 | O00418O75344 | 0:0 | hu.MAP | |||
| CDC37L1EEF2KFKBP6OSBP | O00418O75344P22059Q7L3B6 | 0:0:0:0 | hu.MAP | |||
| AGAP3CDC37L1EEF2KFKBP6 | O00418O75344Q7L3B6Q96P47 | 0:0:0:0 | hu.MAP | |||
| CALM1EEF2K | O00418P0DP23 | 2:2 | PDB | PDB:8fnyPDB:5j8hPDB:7shqPDB:8gm5PDB:8gm4PDB:8fo6 | ||
| EEF2MAPK13MAPKAPK3PPM1ARRM2UBC | O15264P0CG48P13639P31350P35813Q16644 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4439 | ||
| BCAT2EEF2KMTGFERPGM2 | O15382P55789Q96G03Q96G04 | 0:0:0:0 | hu.MAP | |||
| BCAT2EEF2KMTGFER | O15382P55789Q96G04 | 0:0:0 | hu.MAP |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryR Sequencing | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
858
Mass
95,338
Sequence
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
3D Structural Models
3D Structure
Electron microscopy (18)
Domain & Motif Annotations
Domain (FT)
17..362; tr-type G
Protein Families (3)
- TRAFAC class translation factor GTPase superfamily
- Classic translation factor GTPase family
- EF-G/EF-2 subfamily
Sequence Similarities
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Clinical Relevance
Disease Involvement (5)
Cancer-related genesDisease variantFDA approved drug targetsNeurodegenerationSpinocerebellar ataxia
Related Diseases
Drug Targets
FDA approved drug targets
Drugs (18)
RESIMMUNELMB-100DANUSERTIBTAGRAXOFUSP-ERZSCYCLOHEXIMIDEOPORTUZUMAB MONATOX(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDECOMPOUND 38 [PMID: 20817473]LACTIMIDOMYCINMOXETUMOMAB PASUDOTOXSS1(DSFV)-PE38AMG-900MK-5108GSK1070916ILORASERTIBTOZASERTIBBI-847325DENILEUKIN DIFTITOX
Interaction Protein (2)
ENSG00000072506ENSG00000174444
Interaction Count
2
Interaction Dataset (2)
intact_biogridbiogrid_opencell
Supporting Publications35
| PMID | Title | Related sentences |
|---|---|---|
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 37926756 | Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 38607062 | Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes. | No related sentences available |
| 38891077 | Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease. | No related sentences available |
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No related sentences available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No related sentences available |