Protein detail

EF2

Elongation factor 2 (EF-2) (EC 3.6.5.-)

Protein symbol EF2	UniProt ID P13639	EVMP score 0.75
Frequency 35	Transmembrane count	Protein classification Cancer-related genesDisease related genesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Elongation factor 2 (EF-2) (EC 3.6.5.-)

Protein Class

Cancer-related genesDisease related genesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Cancer-related genes:Candidate cancer biomarkers
Disease related genes
FDA approved drug targets:Biotech drugs

Ensembl

ENSG00000167658

Entrez Gene Symbol

EEF2

Gene Synonym

EEF-2EF2

Gene Description

Eukaryotic translation elongation factor 2

Chromosome

Position

3976056-3985463

Frequency

EVMP Score

0.75

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificAstrocytesSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Cancer-related genes:Candidate cancer biomarkers
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

23 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
EEF2	CDK1	P06493	S	595	phosphorylation	PhosphoSite
EEF2	CDK1	P06493	S	360	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:24958351
EEF2	CDK2	P24941	T	435	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
EEF2	CDK2	P24941	S	595	phosphorylation	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:23184662 ProtMapper:24958351 ProtMapper:24167567
EEF2	NEK2	P51955	S	595	phosphorylation	PhosphoSite
EEF2	EGF	P01133	T	57	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983
EEF2	HTR2C	P28335	T	57	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:27821870
EEF2	TRPM7	Q96QT4	T	57	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:21112387
EEF2	PREP	P48147	T	57	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:29371602
EEF2	NUP214	P35658	T	57	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:18728285

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Ligand-Receptor Signaling

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EF2K	O00418	EF2	P13639	Yes	No	Yes	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAInnateDBNCI-PID_ProtMapperHPRDCui2007CA1WangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phos	CA1:9133370 ProtMapper:21203441 HINT:8386634 ProtMapper:8386634 HPRD:8386634 ProtMapper:30686592 ProtMapper:91085562 ProtMapper:22669845 ProtMapper:29610153 ProtMapper:33673713 ProtMapper:20837011 ProtMapper:30214154 ProtMapper:33341653 HINT:15024086 HPRD-phos:18669648 ProtMapper:32499677 HPRD-phos:18767875 ProtMapper:12194824 HPRD-phos:8386634 PhosphoSite:16858730 ProtMapper:19413330 ProtMapper:25686034 CA1:2704236 HPRD:91085562 ProtMapper:31271100 CA1:2458772 KEA:91085562 ProtMapper:21112387 ProtMapper:32245093 ProtMapper:33614241 ProtMapper:19152646 ProtMapper:21307130 KEA:17081983 HPRD-phos:20068231 SIGNOR:2261989 ProtMapper:2261989 ProtMapper:11500364 HPRD-phos:91085562 InnateDB:15024086 ProtMapper:18212344 ProtMapper:25047940 ProtMapper:18767875 HINT:22669845 SIGNOR:12194824 ProtMapper:19651622 ProtMapper:32859902 ProtMapper:29337352 HPRD-phos:18212344 ProtMapper:25623400 ProtMapper:22352903 ProtMapper:33734395 ProtMapper:17287340 ProtMapper:24574971 PhosphoSite:30218597 ProtMapper:24955726 ProtMapper:29150352 CA1:3906654 KEA:16083285 HINT:91085562 ProtMapper:28060762 SIGNOR:8386634 CA1:3693353 KEA:8386634 ProtMapper:31266475 HPRD-phos:17287340 ProtMapper:20166139 ProtMapper:20068231 ProtMapper:24958351 ProtMapper:30218597 HPRD-phos:19413330 ProtMapper:18669648 ProtMapper:23184662 HPRD-phos:19651622 PhosphoSite:23184662 HPRD-phos:20166139
CSK	P41240	EF2	P13639	Yes	No	Yes	SIGNOR	SIGNOR:24648518
DPH5	Q9H2P9	EF2	P13639	Yes	No	Yes	SIGNOR	SIGNOR:23486472
EF2	P13639		COMPLEX:CHEBI:33699_P05386_P05387_P05388_P08708_P08865_P15880_P18077_P18124_P18621_P22090_P23396_P25398_P26373_P27635_P30050_P32969_P35268_P36578_P39019_P39023_P40429_P42677_P42766_P46776_P46777_P46778_P46779_P46781_P46782_P46783_P47914_P49207_P50914_P60866_P61247_P61254_P61313_P61353_P61513_P61927_P62081_P62241_P62244_P62249_P62263_P62266_P62269_P62273_P62277_P62280_P62424_P62701_P62750_P62753_P62829_P62841_P62847_P62851_P62854_P62857_P62861_P62888_P62891_P62899_P62906_P62910_P62913_P62917_P62945_P62979_P62987_P63173_P63220_P83731_P83881_P84098_Q02543_Q02878_Q07020_Q6P5R6_Q71UM5_Q8TD47_Q92901_Q969Q0_Q96EH5_Q96L21_Q9UNX3_Q9Y3U8	Yes	Yes	No	SIGNOR	SIGNOR:14709557
PP2AA	P67775	EF2	P13639	Yes	Yes	No	SIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper	ProtMapper:8386634 HPRD:8386634 DEPOD:8386634 SIGNOR:8386634 DEPOD:2176079 DEPOD:2555220

Protein Complex Composition

14 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster64	EEF2 FKBP1A FKBP1B GRHPR ITPA NPM1 NPM2 NPM3	O75607 P06748 P13639 P62942 P68106 Q86SE8 Q9BY32 Q9UBQ7	1:1:1:1:1:1:1:1	Compleat	Compleat:HC2793	22036573
HT_SC_Cluster231	EEF2 EIF4A1 EIF4A2 EIF4A3	P13639 P38919 P60842 Q14240	1:1:1:1	Compleat	Compleat:HC1329
HT_SC_Cluster58	DPH1 DPH2 DPH3 EEF2 HGH1 SERGEF	P13639 Q96FX2 Q9BQC3 Q9BTY7 Q9BZG8 Q9UGK8	1:1:1:1:1:1	Compleat	Compleat:HC1661
	EEF2K FKBP6	O00418 O75344	0:0	hu.MAP
	CDC37L1 EEF2K FKBP6 OSBP	O00418 O75344 P22059 Q7L3B6	0:0:0:0	hu.MAP
	AGAP3 CDC37L1 EEF2K FKBP6	O00418 O75344 Q7L3B6 Q96P47	0:0:0:0	hu.MAP
	CALM1 EEF2K	O00418 P0DP23	2:2	PDB	PDB:8fnyPDB:5j8hPDB:7shqPDB:8gm5PDB:8gm4PDB:8fo6
	EEF2 MAPK13 MAPKAPK3 PPM1A RRM2 UBC	O15264 P0CG48 P13639 P31350 P35813 Q16644	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4439
	BCAT2 EEF2KMT GFER PGM2	O15382 P55789 Q96G03 Q96G04	0:0:0:0	hu.MAP
	BCAT2 EEF2KMT GFER	O15382 P55789 Q96G04	0:0:0	hu.MAP

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryR Sequencing	1	37886648

Sequence, Structure & Domains

Sequences

Length

858

Mass

95,338

Sequence

MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL

3D Structural Models

3D Structure

Electron microscopy (18)

Domain & Motif Annotations

Domain (FT)

17..362; tr-type G

Protein Families

TRAFAC class translation factor GTPase superfamily
Classic translation factor GTPase family
EF-G/EF-2 subfamily

Sequence Similarities

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantFDA approved drug targetsNeurodegenerationSpinocerebellar ataxia

Drug Targets

FDA approved drug targets

Drugs

RESIMMUNE LMB-100 DANUSERTIB TAGRAXOFUSP-ERZS CYCLOHEXIMIDE OPORTUZUMAB MONATOX (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE COMPOUND 38 [PMID: 20817473]LACTIMIDOMYCIN MOXETUMOMAB PASUDOTOX SS1(DSFV)-PE38 AMG-900 MK-5108 GSK1070916 ILORASERTIB TOZASERTIB BI-847325 DENILEUKIN DIFTITOX

Antibody

CAB007795 HPA040534 HPA057351

Interaction Protein

ENSG00000072506ENSG00000174444

Interaction Count

Interaction Dataset

intact_biogridbiogrid_opencell