Protein detail

PLSL

Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)

Entry name PLSL	UniProt ID P13796	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)

Protein Class

Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000136167

Entrez Gene Symbol

LCP1

Gene Synonym

CP64L-PLASTINLC64PPLS2

Gene Description

Lymphocyte cytosolic protein 1

Chromosome

Position

46125920-46211871

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAstrocytesSingle-Nuclei Brain SpecificpericyteBlood Cell Specificnon-classical monocyte

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M10 Pid bcr 5pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

15 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LCP1	PRKACA	P17612	S	5	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:20230923 HPRD:10446213 HPRD:19651622 HPRD:20058876 KEA:10446213 ProtMapper:16636079 HPRD:20166139
LCP1	PRKACA	P17612	S	7	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
LCP1	PRKCD	Q05655	S	5	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
LCP1	SGK2	Q9HBY8	S	5	phosphorylation	PhosphoSite
LCP1	RPS6KA1	Q15418	S	5	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LCP1	SGK3	Q96BR1	S	5	phosphorylation	PhosphoSite
LCP1	PRKCA	P17252	S	5	phosphorylation	PhosphoSite
LCP1	RPS6KA3	P51812	S	5	phosphorylation	RLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:26631483
LCP1	PRKX	P51817	S	7	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
LCP1	PRKX	P51817	S	5	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KAPCA	P17612	PLSL	P13796	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	SIGNOR:16636079 HPRD:10446213 HPRD-phos:20058876 ProtMapper:16636079 ProtMapper:20058876 ProtMapper:19651622 ProtMapper:20166139 HPRD-phos:20230923 ProtMapper:20230923 HPRD-phos:10446213 KEA:10446213 ProtMapper:10446213 HPRD-phos:19651622 HPRD-phos:20166139
KPCA	P17252	PLSL	P13796	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:16636079 PhosphoSite:10446213 PhosphoSite:16625055 PhosphoSite:33449151 PhosphoSite:17294403 PhosphoSite:26631483 PhosphoSite:20169155 PhosphoSite:19799649

Protein Complex Composition

9 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
EIF3A EIF3B EIF3F EIF3H EIF3I EIF3J EIF4A1 EIF4A2 EIF4E EIF4G1 EIF4G2 EIF4G3 GCA LCP1 UBC	O00303 O15372 O43432 O75822 P06730 P0CG48 P13796 P28676 P55884 P60842 P78344 Q04637 Q13347 Q14152 Q14240	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6677
MIF NPC1 POLRMT SLC25A15 UBC UBE2NL UBLCP1	O00411 O15118 P0CG48 P14174 Q5JXB2 Q8WVY7 Q9Y619	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5688
NPC1 POLRMT SLC25A15 SLC2A8 UBC UBE2NL UBLCP1	O00411 O15118 P0CG48 Q5JXB2 Q8WVY7 Q9NY64 Q9Y619	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5649
NPC1 POLRMT SLC25A15 SLC2A6 UBC UBE2NL UBLCP1	O00411 O15118 P0CG48 Q5JXB2 Q8WVY7 Q9UGQ3 Q9Y619	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7021
BRD4 PARP1 PCNA PSMD2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA2 TFAM TREX1 UBLCP1 XRCC5 XRCC6	O60885 P09874 P12004 P12956 P13010 P15927 P35249 P35250 P35251 P40937 P40938 Q00059 Q13200 Q8WVY7 Q9NSU2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8877
ALOX15 DDX19B IL36RN LCP1	P13796 P16050 Q9UBH0 Q9UMR2	0:0:0:0	hu.MAP
LCP1 RNF41 TTC1	P13796 Q99614 Q9H4P4	0:0:0	hu.MAP2
DDX19B LCP1	P13796 Q9UMR2	0:0	hu.MAP
Q6LCP1	Q6LCP1	2	PDB	PDB:8jq0

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	31382537 38716512

Sequence, Structure & Domains

Sequences

Length

627

Mass

70,288

Sequence

MARGSVSDEEMMELREAFAKVDTDGNGYISFNELNDLFKAACLPLPGYRVREITENLMATGDLDQDGRISFDEFIKIFHGLKSTDVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANYHLENAGCNKIGNFSTDIKDSKAYYHLLEQVAPKGDEEGVPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNRYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVELGKNQAKFSLVGIGGQDLNEGNRTLTLALIWQLMRRYTLNILEEIGGGQKVNDDIIVNWVNETLREAKKSSSISSFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLNDDEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGMKRV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13796-1; Sequence=Displayed; Name=2; IsoId=P13796-2; Sequence=VSP_056450, VSP_056451

Alternative Sequence

1..25; MARGSVSDEEMMELREAFAKVDTDG -> MCAEDGDSKFSMSISMNSPFLEILH (in isoform 2); 26..456; Missing (in isoform 2)

3D Structural Models

Turn

64..66; 566..568; 605..607; 621..623

Helix

8..21; 31..40; 47..59; 71..80; 85..94; 520..532; 545..548; 550..559; 576..593; 601..604; 609..612; 615..620

Beta Strand

27..29; 61..63

3D Structure

Electron microscopy (1); NMR spectroscopy (3)

Domain & Motif Annotations

Domain (FT)

9..44; EF-hand 1; 49..84; EF-hand 2; 120..236; Calponin-homology (CH) 1; 264..375; Calponin-homology (CH) 2; 394..503; Calponin-homology (CH) 3; 515..624; Calponin-homology (CH) 4

Region

106..379; Actin-binding 1; 380..624; Actin-binding 2

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variant

Antibody

HPA000895 HPA019493 CAB020673

Interaction Protein

ENSG00000102024

Interaction Count

Interaction Dataset

biogrid_bioplex