Protein detail

PLST

Plastin-3 (T-fimbrin) (T-plastin)

Entry name PLST	UniProt ID P13797	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Plastin-3 (T-fimbrin) (T-plastin)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Skeletal diseases

Ensembl

ENSG00000102024

Entrez Gene Symbol

PLS3

Gene Synonym

T-plastin

Gene Description

Plastin 3

Chromosome

Position

115561174-115650861

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue Specificbone marrowCell SpecificBrain inhibitory neurons

Function & Pathway6

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Skeletal diseases

Cellular Component (5)

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DPP8 PLS3 WDR4	P13797 P57081 Q6V1X1	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	1	28914500

Sequence, Structure & Domains11

Sequences

Length

630

Mass

70,811

Sequence

MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMLDGDRNKDGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIGGQDLNDGNQTLTLALVWQLMRRYTLNVLEDLGDGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P13797-1; Sequence=Displayed; Name=2; IsoId=P13797-2; Sequence=VSP_056236, VSP_056237; Name=3; IsoId=P13797-3; Sequence=VSP_056235

Alternative Sequence

1..45; Missing (in isoform 3); 1..24; MDEMATTQISKDELDELKEAFAKV -> ME (in isoform 2); 296; I -> IKLIDFSNSV (in isoform 2)

3D Structural Models

Turn

137..139; 144..146; 151..154; 294..298; 326..329; 345..348; 472..474; 532..535; 569..571; 579..581

Helix

123..136; 155..159; 160..162; 164..173; 180..182; 190..206; 216..220; 224..244; 261..265; 269..283; 300..309; 333..344; 355..359; 363..374; 398..409; 419..422; 427..435; 442..444; 455..471; 483..487; 491..512; 525..531; 547..549; 553..562; 582..596; 605..608; 612..626

Beta Strand

315..317; 452..454; 513..517

3D Structure

Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

12..47; EF-hand 1; 52..87; EF-hand 2; 123..239; Calponin-homology (CH) 1; 267..378; Calponin-homology (CH) 2; 397..506; Calponin-homology (CH) 3; 518..627; Calponin-homology (CH) 4

Region

109..382; Actin-binding 1; 383..627; Actin-binding 2

Clinical Relevance5

Disease Involvement (2)

Disease variantOsteoporosis

Antibody (3)

HPA000895 HPA020433 HPA076083

Interaction Protein (2)

ENSG00000120756ENSG00000136167

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No abstract available