Protein detail
PLST
Plastin-3 (T-fimbrin) (T-plastin)
Protein symbol PLST | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Plastin-3 (T-fimbrin) (T-plastin)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Ensembl
Entrez Gene Symbol
Gene Synonym
T-plastin
Gene Description
Plastin 3
Chromosome
X
Position
115561174-115650861
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificBrain inhibitory neurons
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 28914500 |
Sequence, Structure & Domains
Sequences
Length
630
Mass
70,811
Sequence
MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMLDGDRNKDGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIGGQDLNDGNQTLTLALVWQLMRRYTLNVLEDLGDGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P13797-1; Sequence=Displayed; Name=2; IsoId=P13797-2; Sequence=VSP_056236, VSP_056237; Name=3; IsoId=P13797-3; Sequence=VSP_056235
Alternative Sequence
1..45; Missing (in isoform 3); 1..24; MDEMATTQISKDELDELKEAFAKV -> ME (in isoform 2); 296; I -> IKLIDFSNSV (in isoform 2)
3D Structural Models
Turn
137..139; 144..146; 151..154; 294..298; 326..329; 345..348; 472..474; 532..535; 569..571; 579..581
Helix
123..136; 155..159; 160..162; 164..173; 180..182; 190..206; 216..220; 224..244; 261..265; 269..283; 300..309; 333..344; 355..359; 363..374; 398..409; 419..422; 427..435; 442..444; 455..471; 483..487; 491..512; 525..531; 547..549; 553..562; 582..596; 605..608; 612..626
Beta Strand
315..317; 452..454; 513..517
3D Structure
Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
12..47; EF-hand 1; 52..87; EF-hand 2; 123..239; Calponin-homology (CH) 1; 267..378; Calponin-homology (CH) 2; 397..506; Calponin-homology (CH) 3; 518..627; Calponin-homology (CH) 4
Region
109..382; Actin-binding 1; 383..627; Actin-binding 2