Protein detail
CBPM
Carboxypeptidase M (CPM) (EC 3.4.17.12)
Entry name CBPM | UniProt ID | EVMP confidence score 0.47 |
Supporting publications (n) 12 | Transmembrane count | Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Carboxypeptidase M (CPM) (EC 3.4.17.12)
Protein Class (4)
EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Description
Carboxypeptidase M
Chromosome
12
Position
68842197-68971570
Supporting publications (n)
12
EVMP confidence score
0.47
Fluorescence & Localization3
Tissue Specificpituitary glandBrain Regional SpecifichypothalamusCell SpecificLactotrophs
Function & Pathway6
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Reactome (2)
Mediation Categories
Metabolism mediation
Relations & Evidence29
Ligand-Receptor Signaling (26)
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | Yes |
| extracellular | extracellular | LOCATE | No | No | No | Yes | Yes |
| extracellular | extracellular | OmniPath | No | No | No | Yes | Yes |
| intracellular | intracellular | LOCATE | No | No | No | Yes | Yes |
| intracellular | intracellular | OmniPath | No | No | No | Yes | Yes |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | No | Yes | Yes |
| m14_carboxypeptidase | cell_surface_peptidase | OmniPath | Yes | No | No | Yes | Yes |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | No | Yes | Yes |
| cell_surface_peptidase | cell_surface_peptidase | OmniPath | Yes | No | No | Yes | Yes |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | Yes |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CBPM | P14384 | HBA | P69905 | Yes | No | Yes | HPRDSIGNOR | SIGNOR:8635221HPRD:8635221 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry [LTQ-FT Ultra]Western blottingMass spectrometry | 1 | 32308722 |
Sequence, Structure & Domains10
Sequences
Length
443
Mass
50,514
Sequence
MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
3D Structural Models
Turn
39..41; 104..106; 234..238; 256..258; 415..418
Helix
25..38; 88..103; 108..116; 127..132; 169..180; 205..207; 209..211; 219..231; 265..271; 290..292; 293..298; 301..308; 309..312
Beta Strand
42..50; 56..65; 75..80; 118..123; 159..161; 183..185; 188..190; 192..199; 243..245; 252..255; 279..287; 314..320; 331..334; 350..353; 357..365; 367..369; 372..378; 383..386
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
21..311; Peptidase M14
Protein Families
Peptidase M14 family
Sequence Similarities
Belongs to the peptidase M14 family.
Clinical Relevance4
Supporting Publications12
| PMID | Title | Abstract |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No abstract available |
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32284825 | Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. | No abstract available |
| 33212158 | Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine. | No abstract available |
| 34186243 | A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. | No abstract available |
| 35194965 | Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles. | No abstract available |
| 37205098 | Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers. | No abstract available |
| 39505756 | Differential proteomic profiles of exosomes in pediatric and adult adamantinomatous craniopharyngioma cyst fluid. | No abstract available |
| 39940641 | Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients. | No abstract available |
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