Protein detail
CBPM
Carboxypeptidase M (CPM) (EC 3.4.17.12)
Entry name CBPM | UniProt ID | EVMP score 0.47 |
Frequency 12 | Transmembrane count | Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Carboxypeptidase M (CPM) (EC 3.4.17.12)
Protein Class
EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Description
Carboxypeptidase M
Chromosome
12
Position
68842197-68971570
Frequency
12
EVMP Score
0.47
Fluorescence & Localization
Tissue Specificpituitary glandBrain Regional SpecifichypothalamusCell SpecificLactotrophs
Function & Pathway
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | Yes |
| receptor | receptor | scConnect | No | Yes | No | Yes | Yes |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | Yes |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | Yes |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | Yes |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CBPM | P14384 | HBA | P69905 | Yes | No | Yes | HPRDSIGNOR | SIGNOR:8635221HPRD:8635221 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry [LTQ-FT Ultra]Western blottingMass spectrometry | 1 | 32308722 |
Sequence, Structure & Domains
Sequences
Length
443
Mass
50,514
Sequence
MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
3D Structural Models
Turn
39..41; 104..106; 234..238; 256..258; 415..418
Helix
25..38; 88..103; 108..116; 127..132; 169..180; 205..207; 209..211; 219..231; 265..271; 290..292; 293..298; 301..308; 309..312
Beta Strand
42..50; 56..65; 75..80; 118..123; 159..161; 183..185; 188..190; 192..199; 243..245; 252..255; 279..287; 314..320; 331..334; 350..353; 357..365; 367..369; 372..378; 383..386
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
21..311; Peptidase M14
Protein Families
Peptidase M14 family
Sequence Similarities
Belongs to the peptidase M14 family.