Protein detail

SUIS

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Entry name SUIS	UniProt ID P14410	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count 1	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Protein Class (7)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

Protein Function (5)

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

13..32; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000090402

Entrez Gene Symbol

Gene Description

Sucrase-isomaltase

Chromosome

Position

164978898-165078496

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificMyonuclei

Function & Pathway7

Protein Function (5)

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence455

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SI	PRKACA	P17612	S	7	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPHPRDKEA	HPRD:8521865 KEA:8521865
SI	PRKX	P51817	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP
SI	PRKY	O43930	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Protein Complex Composition (432)

432 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Ub:RING_E3	SIAH3 UBB	P0CG47 Q8IW03	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	SIAH1 UBC	P0CG48 Q8IUQ4	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	SIAH3 UBC	P0CG48 Q8IW03	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RPS27A SIAH1	P62979 Q8IUQ4	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RPS27A SIAH3	P62979 Q8IW03	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	SIAH1 UBA52	P62987 Q8IUQ4	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	SIAH3 UBA52	P62987 Q8IW03	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ubiquitin E3 ligase (SIAH1SIPSKP1ATBL1X)	CACYBP SIAH1 SKP1 TBL1X	O60907 P63208 Q8IUQ4 Q9HB71	1:1:1:1	CompleatCORUM	CORUM:1255Compleat:HC1093	11389839
chromatin silencing complex	BAHD1 BAZ2A RRP8 SIRT1 SIRT2 SMARCA5 SUV39H1	O43159 O43463 O60264 Q8IXJ6 Q8TBE0 Q96EB6 Q9UIF9	1:1:1:1:1:1:1	Compleat	Compleat:HC830	18485871 19666599 12697818
chromatin silencing complex	NOLC1 ORC1 SIRT1	Q13415 Q14978 Q96EB6	1:1:1	Compleat	Compleat:HC2222	15899856

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	32331267

Sequence, Structure & Domains12

Sequences

Length

1,827

Mass

209,453

Sequence

MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIGPLVYSDQYLQISTRLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNNTLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVLLIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAPECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDMLQFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDSWLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNSYGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPEVATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDYMERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVFVKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREIVDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTICMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWGGHWLGDNYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFYPYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRPLLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVRGQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFWDDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS

3D Structural Models

Turn

196..199; 206..209; 308..310; 402..407; 507..509; 524..526; 539..542; 737..739; 765..767; 909..912

Helix

71..73; 85..91; 215..217; 331..342; 350..353; 365..377; 389..391; 393..395; 408..417; 442..450; 480..496; 535..537; 555..558; 559..561; 562..577; 594..596; 609..624; 643..653; 672..675; 680..694; 696..709; 718..721; 725..729; 806..809; 840..843; 868..872

Beta Strand

65..68; 75..77; 99..103; 105..107; 114..121; 123..132; 138..140; 144..154; 157..163; 175..177; 189..195; 200..205; 210..214; 221..223; 226..232; 234..236; 238..244; 247..250; 254..261; 278..284; 291..296; 302..307; 311..319; 321..330; 384..387; 421..426; 459..462; 465..467; 470..473; 500..504; 512..515; 585..588; 599..601; 606..608; 629..631; 637..639; 656..658; 713..715; 732..736; 740..743; 751..757; 762..764; 775..781; 788..792; 795..800; 814..819; 824..832; 835..837; 846..854; 857..865; 874..882; 890..894; 900..902; 905..908; 913..916; 927..930

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

45..55; Low complexity

Domain (FT)

61..110; P-type 1; 932..978; P-type 2

Region

40..61; Disordered; 110..1007; Isomaltase; 1008..1827; Sucrase

Protein Families

Glycosyl hydrolase 31 family

Sequence Similarities

Belongs to the glycosyl hydrolase 31 family.

Clinical Relevance4

Disease Involvement (2)

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (8)

ACARBOSE CELGOSIVIR STREPTOZOCIN SACROSIDASE VOGLIBOSE MIFEPRISTONE DEXAMETHASONE INSULIN, REGULAR, HUMAN

Antibody

HPA011897