Protein detail

SUIS

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Protein symbol SUIS	UniProt ID P14410	EVMP score 0.38
Frequency	Transmembrane count 1	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

Basic Information

Protein Names

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Protein Class

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

13..32; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000090402

Entrez Gene Symbol

Gene Description

Sucrase-isomaltase

Chromosome

Position

164978898-165078496

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificMyonuclei

Function & Pathway

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SI	PRKACA	P17612	S	7	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPHPRDKEA	HPRD:8521865 KEA:8521865
SI	PRKX	P51817	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP
SI	PRKY	O43930	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP

Ligand-Receptor Signaling

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	Ramilowski_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Ramilowski_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

432 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
EYA1-SIX1 complex	EYA1 SIX1	Q15475 Q99502	0:0	CORUM	CORUM:7363	11734542
EYA1-SIX2 complex	EYA1 SIX2	Q99502 Q9NPC8	0:0	CORUMhu.MAP2	CORUM:7364	11734542
Ecsit complex (ECSITMT-CO2NDUFA1MT-ND1TRAF6NDUFAF1)	ECSIT MT-CO2 MT-ND1 NDUFA1 NDUFAF1 TRAF6	O15239 P00403 P03886 Q9BQ95 Q9Y375 Q9Y4K3	1:1:1:1:1:1	CompleatCORUM	CORUM:2939Compleat:HC769	17344420
Ecsit complex (ECSITNDUFS3NDUFAF1)	ECSIT NDUFAF1 NDUFS3	O75489 Q9BQ95 Q9Y375	1:1:1	CompleatCORUM	Compleat:HC454CORUM:2942	17344420
Ecsit complex (ECSITNDUFS3TOM20)	ECSIT NDUFS3 TOMM20	O75489 Q15388 Q9BQ95	1:1:1	CompleatCORUM	Compleat:HC2672CORUM:2938	17344420
Ecsit complex (Ecsit2-Smad1)	ECSIT SMAD1 SMAD5 SMAD9	O15198 Q15797 Q99717 Q9BQ95	1:1:1:1	Compleat	Compleat:HC3161	14633973
Ecsit complex (Ecsit2-Smad4)	ECSIT SMAD4	Q13485 Q9BQ95	1:1	Compleat	Compleat:HC1354	14633973
Ecsit complex (Smad1-Smad4-Ecsit2)	ECSIT SMAD1 SMAD4 SMAD5 SMAD9	O15198 Q13485 Q15797 Q99717 Q9BQ95	1:1:1:1:1	Compleat	Compleat:HC1415	14633973
Eya1/3-Dach1/2-Six1 complex	DACH1 DACH2 EYA1 EYA2 EYA3 SIX1	O00167 Q15475 Q96NX9 Q99502 Q99504 Q9UI36	1:1:1:1:1:1	Compleat	Compleat:HC629	14628042
FOXO1-FHL2-SIRT1 complex	FHL2 FOXO1 SIRT1	Q12778 Q14192 Q96EB6	1:1:1	CompleatCORUM	CORUM:2590Compleat:HC549	15692560

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	32331267

Sequence, Structure & Domains

Sequences

Length

1,827

Mass

209,453

Sequence

MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIGPLVYSDQYLQISTRLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNNTLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVLLIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAPECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDMLQFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDSWLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNSYGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPEVATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDYMERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVFVKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREIVDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTICMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWGGHWLGDNYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFYPYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRPLLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVRGQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFWDDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS

3D Structural Models

Turn

196..199; 206..209; 308..310; 402..407; 507..509; 524..526; 539..542; 737..739; 765..767; 909..912

Helix

71..73; 85..91; 215..217; 331..342; 350..353; 365..377; 389..391; 393..395; 408..417; 442..450; 480..496; 535..537; 555..558; 559..561; 562..577; 594..596; 609..624; 643..653; 672..675; 680..694; 696..709; 718..721; 725..729; 806..809; 840..843; 868..872

Beta Strand

65..68; 75..77; 99..103; 105..107; 114..121; 123..132; 138..140; 144..154; 157..163; 175..177; 189..195; 200..205; 210..214; 221..223; 226..232; 234..236; 238..244; 247..250; 254..261; 278..284; 291..296; 302..307; 311..319; 321..330; 384..387; 421..426; 459..462; 465..467; 470..473; 500..504; 512..515; 585..588; 599..601; 606..608; 629..631; 637..639; 656..658; 713..715; 732..736; 740..743; 751..757; 762..764; 775..781; 788..792; 795..800; 814..819; 824..832; 835..837; 846..854; 857..865; 874..882; 890..894; 900..902; 905..908; 913..916; 927..930

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

45..55; Low complexity

Domain (FT)

61..110; P-type 1; 932..978; P-type 2

Region

40..61; Disordered; 110..1007; Isomaltase; 1008..1827; Sucrase

Protein Families

Glycosyl hydrolase 31 family

Sequence Similarities

Belongs to the glycosyl hydrolase 31 family.

Clinical Relevance

Disease Involvement

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

ACARBOSE CELGOSIVIR STREPTOZOCIN SACROSIDASE VOGLIBOSE MIFEPRISTONE DEXAMETHASONE INSULIN, REGULAR, HUMAN

Antibody

HPA011897