Protein detail

SUIS

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Entry name SUIS	UniProt ID P14410	EVMP score 0.38
Frequency	Transmembrane count 1	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Protein Class

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

13..32; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000090402

Entrez Gene Symbol

Gene Description

Sucrase-isomaltase

Chromosome

Position

164978898-165078496

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificMyonuclei

Function & Pathway

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SI	PRKACA	P17612	S	7	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPHPRDKEA	HPRD:8521865 KEA:8521865
SI	PRKX	P51817	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP
SI	PRKY	O43930	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP

Ligand-Receptor Signaling

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	Ramilowski_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Ramilowski_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

432 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CDC14B EP300 GLA KIF13A PTBP1 SIRT2	O60729 P06280 P26599 Q09472 Q8IXJ6 Q9H1H9	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7988
CDC14B EP300 KIF13A NAGA SIRT2 UBC	O60729 P0CG48 P17050 Q09472 Q8IXJ6 Q9H1H9	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4409
CDC14B EP300 KIF13A PTBP1 SIRT2 SRSF2	O60729 P26599 Q01130 Q09472 Q8IXJ6 Q9H1H9	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8878
CDC14B FZR1 SIRT2	O60729 Q8IXJ6 Q9UM11	1:1:1	CompleatCFinder	Compleat:HC6070
CSNK2A1 H2BC12 H3C11 H4C4 HDGF NEK9 PSIP1 SP1 SSRP1 SUPT16H	O60814 O75475 P08047 P51858 P62805 P68400 P68431 Q08945 Q8TD19 Q9Y5B9	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4667
BRD4 FKBP10 H2AC20 H2AX H2BC21 H3C11 H4C4 KAT8 MACROH2A1 MSL3 RCC1 SIRT7	O60885 O75367 P16104 P18754 P62805 P68431 Q16777 Q16778 Q8N5Y2 Q96AY3 Q9H7Z6 Q9NRC8	1:1:1:1:2:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8317
BRD4 SIRT7	O60885 Q9NRC8	2:1	PDB	PDB:6g0s
BARD1 EZH2 HDAC11 KMT2E NCOR1 NCOR2 PPIA SIRT1 SRRM1 TBL1X	O60907 O75376 P62937 Q15910 Q8IYB3 Q8IZD2 Q96DB2 Q96EB6 Q99728 Q9Y618	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5719
ASH1L BARD1 EZH2 HDAC11 HSPA1L NCOR2 PPIF SIRT1 SLC25A4 SRRM1 TBL1X UBC	O60907 P0CG48 P12235 P30405 P34931 Q15910 Q8IYB3 Q96DB2 Q96EB6 Q99728 Q9NR48 Q9Y618	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8305
BARD1 EZH2 HDAC11 KMT2E PPIA RCOR1 SIRT1 SRRM1 SUMO3 TBL1X	O60907 P55854 P62937 Q15910 Q8IYB3 Q8IZD2 Q96DB2 Q96EB6 Q99728 Q9UKL0	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6926

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	32331267

Sequence, Structure & Domains

Sequences

Length

1,827

Mass

209,453

Sequence

MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIGPLVYSDQYLQISTRLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNNTLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVLLIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAPECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDMLQFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDSWLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNSYGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPEVATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDYMERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVFVKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREIVDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTICMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWGGHWLGDNYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFYPYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRPLLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVRGQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFWDDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS

3D Structural Models

Turn

196..199; 206..209; 308..310; 402..407; 507..509; 524..526; 539..542; 737..739; 765..767; 909..912

Helix

71..73; 85..91; 215..217; 331..342; 350..353; 365..377; 389..391; 393..395; 408..417; 442..450; 480..496; 535..537; 555..558; 559..561; 562..577; 594..596; 609..624; 643..653; 672..675; 680..694; 696..709; 718..721; 725..729; 806..809; 840..843; 868..872

Beta Strand

65..68; 75..77; 99..103; 105..107; 114..121; 123..132; 138..140; 144..154; 157..163; 175..177; 189..195; 200..205; 210..214; 221..223; 226..232; 234..236; 238..244; 247..250; 254..261; 278..284; 291..296; 302..307; 311..319; 321..330; 384..387; 421..426; 459..462; 465..467; 470..473; 500..504; 512..515; 585..588; 599..601; 606..608; 629..631; 637..639; 656..658; 713..715; 732..736; 740..743; 751..757; 762..764; 775..781; 788..792; 795..800; 814..819; 824..832; 835..837; 846..854; 857..865; 874..882; 890..894; 900..902; 905..908; 913..916; 927..930

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

45..55; Low complexity

Domain (FT)

61..110; P-type 1; 932..978; P-type 2

Region

40..61; Disordered; 110..1007; Isomaltase; 1008..1827; Sucrase

Protein Families

Glycosyl hydrolase 31 family

Sequence Similarities

Belongs to the glycosyl hydrolase 31 family.

Clinical Relevance

Disease Involvement

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

ACARBOSE CELGOSIVIR STREPTOZOCIN SACROSIDASE VOGLIBOSE MIFEPRISTONE DEXAMETHASONE INSULIN, REGULAR, HUMAN

Antibody

HPA011897