Protein detail

SUIS

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Entry name SUIS	UniProt ID P14410	EVMP score 0.38
Frequency	Transmembrane count 1	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Protein Class

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

13..32; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000090402

Entrez Gene Symbol

Gene Description

Sucrase-isomaltase

Chromosome

Position

164978898-165078496

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificMyonuclei

Function & Pathway

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SI	PRKACA	P17612	S	7	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPHPRDKEA	HPRD:8521865 KEA:8521865
SI	PRKX	P51817	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP
SI	PRKY	O43930	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP

Ligand-Receptor Signaling

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Page 1 of 2Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

432 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
HDAC1 NCOR1 SIN3A	O75376 Q13547 Q96ST3	0:0:0	KEGG-MEDICUS
HDAC2 NCOR1 SIN3A	O75376 Q92769 Q96ST3	0:0:0	KEGG-MEDICUS
ARID4A BRMS1 BRMS1L H2AC15 H4C4 HDAC1 HDAC2 ING1 ING2 MORF4L2 PHF12 RBBP4 RBBP7 SAP30 SIN3A	O75446 P0C0S8 P29374 P62805 Q09028 Q13547 Q15014 Q16576 Q5PSV4 Q92769 Q96QT6 Q96ST3 Q9H160 Q9HCU9 Q9UK53	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5656
ARID4A ARID4B BRMS1 BRMS1L FOXG1 H4C4 HDAC1 HDAC2 HSPA4 ING1 ING2 PHF12 SAP30 SIN3A TLE3	O75446 P29374 P34932 P55316 P62805 Q04726 Q13547 Q4LE39 Q5PSV4 Q92769 Q96QT6 Q96ST3 Q9H160 Q9HCU9 Q9UK53	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9103
ARID4A ARID4B BRMS1 BRMS1L FOXG1 HDAC1 HDAC2 HSPA4 ING1 ING2 PHF12 RBBP4 RBBP7 SAP30 SIN3A	O75446 P29374 P34932 P55316 Q09028 Q13547 Q16576 Q4LE39 Q5PSV4 Q92769 Q96QT6 Q96ST3 Q9H160 Q9HCU9 Q9UK53	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6941
ARID4A ARID4B BRMS1 BRMS1L FOXA1 HDAC1 HDAC2 ING1 ING2 ONECUT1 PHF12 RBBP4 RBBP7 SAP30 SIN3A	O75446 P29374 P55317 Q09028 Q13547 Q16576 Q4LE39 Q5PSV4 Q92769 Q96QT6 Q96ST3 Q9H160 Q9HCU9 Q9UBC0 Q9UK53	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6914
ARID4A BRMS1 BRMS1L H3-4 H3C11 H4C4 HDAC1 HDAC2 ING1 ING2 PHF12 RBBP4 RBBP7 SAP30 SIN3A	O75446 P29374 P62805 P68431 Q09028 Q13547 Q16576 Q16695 Q5PSV4 Q92769 Q96QT6 Q96ST3 Q9H160 Q9HCU9 Q9UK53	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6316
ARID4A ARID4B BRMS1 BRMS1L CTBP1 H3-4 H4C4 HDAC1 HDAC2 ING1 ING2 RBBP4 RBBP7 SAP30 SIN3A	O75446 P29374 P62805 Q09028 Q13363 Q13547 Q16576 Q16695 Q4LE39 Q5PSV4 Q92769 Q96ST3 Q9H160 Q9HCU9 Q9UK53	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7975
ARID4A ARID4B BRMS1 BRMS1L H4C4 HDAC1 HDAC2 ING1 ING2 PHF12 RBBP4 RBBP7 SAP30 SIN3A ZNF420	O75446 P29374 P62805 Q09028 Q13547 Q16576 Q4LE39 Q5PSV4 Q8TAQ5 Q92769 Q96QT6 Q96ST3 Q9H160 Q9HCU9 Q9UK53	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9858
ARID4A ARID4B BAHCC1 BRMS1 BRMS1L FOXK1 ING1 ING2 SAP130 SAP30 SIN3A SINHCAF SUDS3	O75446 P29374 P85037 Q4LE39 Q5PSV4 Q96ST3 Q9H0E3 Q9H160 Q9H7L9 Q9HCU9 Q9NP50 Q9P281 Q9UK53	0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP

Page 26 of 44Previous Next

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	32331267

Sequence, Structure & Domains

Sequences

Length

1,827

Mass

209,453

Sequence

MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIGPLVYSDQYLQISTRLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNNTLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVLLIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAPECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDMLQFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDSWLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNSYGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPEVATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDYMERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVFVKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREIVDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTICMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWGGHWLGDNYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFYPYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRPLLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVRGQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFWDDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS

3D Structural Models

Turn

196..199; 206..209; 308..310; 402..407; 507..509; 524..526; 539..542; 737..739; 765..767; 909..912

Helix

71..73; 85..91; 215..217; 331..342; 350..353; 365..377; 389..391; 393..395; 408..417; 442..450; 480..496; 535..537; 555..558; 559..561; 562..577; 594..596; 609..624; 643..653; 672..675; 680..694; 696..709; 718..721; 725..729; 806..809; 840..843; 868..872

Beta Strand

65..68; 75..77; 99..103; 105..107; 114..121; 123..132; 138..140; 144..154; 157..163; 175..177; 189..195; 200..205; 210..214; 221..223; 226..232; 234..236; 238..244; 247..250; 254..261; 278..284; 291..296; 302..307; 311..319; 321..330; 384..387; 421..426; 459..462; 465..467; 470..473; 500..504; 512..515; 585..588; 599..601; 606..608; 629..631; 637..639; 656..658; 713..715; 732..736; 740..743; 751..757; 762..764; 775..781; 788..792; 795..800; 814..819; 824..832; 835..837; 846..854; 857..865; 874..882; 890..894; 900..902; 905..908; 913..916; 927..930

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

45..55; Low complexity

Domain (FT)

61..110; P-type 1; 932..978; P-type 2

Region

40..61; Disordered; 110..1007; Isomaltase; 1008..1827; Sucrase

Protein Families

Glycosyl hydrolase 31 family

Sequence Similarities

Belongs to the glycosyl hydrolase 31 family.

Clinical Relevance

Disease Involvement

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

ACARBOSE CELGOSIVIR STREPTOZOCIN SACROSIDASE VOGLIBOSE MIFEPRISTONE DEXAMETHASONE INSULIN, REGULAR, HUMAN

Antibody

HPA011897