Protein detail

SUIS

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Entry name SUIS	UniProt ID P14410	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count 1	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]

Protein Class (7)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteins

Protein Function (5)

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

13..32; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000090402

Entrez Gene Symbol

Gene Description

Sucrase-isomaltase

Chromosome

Position

164978898-165078496

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificMyonuclei

Function & Pathway7

Protein Function (5)

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence455

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SI	PRKACA	P17612	S	7	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPHPRDKEA	HPRD:8521865 KEA:8521865
SI	PRKX	P51817	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP
SI	PRKY	O43930	S	7	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMP

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Protein Complex Composition (432)

432 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
NCOR-SIN3-RPD3 complex	HDAC2 NCOR2 SIN3A SIN3B	O75182 Q92769 Q96ST3 Q9Y618	1:1:1:1	CompleatCORUM	CORUM:745Compleat:HC284	9139820
NCOR2 complex	HDAC1 HDAC2 HDAC3 NCOR1 NCOR2 SAP30 SIN3A	O15379 O75376 O75446 Q13547 Q92769 Q96ST3 Q9Y618	1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC1910CORUM:1505	11013263
NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex	HDAC1 HIPK2 NKX3-1 NKX3-2 RBBP4 SIN3A TLE1 TLE2 TLE3 TLE4 TLE6	P78367 Q04724 Q04725 Q04726 Q04727 Q09028 Q13547 Q96ST3 Q99801 Q9H2X6 Q9H808	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC3259	10559189
NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex	HDAC1 HIPK2 NKX3-1 RBBP4 SIN3A TLE1	Q04724 Q09028 Q13547 Q96ST3 Q99801 Q9H2X6	0:0:0:0:0:0	CORUM	CORUM:3149	10559189
Nkx3.2-SMAD1-SMAD4-HDAC-Sin3A complex	HDAC1 HDAC2 NKX3-2 RBBP4 RBBP7 SIN3A SIN3B SMAD1 SMAD4 SMAD5 SMAD9	O15198 O75182 P78367 Q09028 Q13485 Q13547 Q15797 Q16576 Q92769 Q96ST3 Q99717	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1919	14612411
PU.1-SIN3A-HDAC complex	HDAC1 SIN3A SPI1	P17947 Q13547 Q96ST3	1:1:1	CompleatCORUM	Compleat:HC3115CORUM:720	11593411
PU.1-Sin3A-Hdac-MeCP2 complex	HDAC1 HDAC2 MECP2 SIN3A SIN3B SPI1	O75182 P17947 P51608 Q13547 Q92769 Q96ST3	1:1:1:1:1:1	Compleat	Compleat:HC3087	14647463
Polycomb repressive complex 4	EED EZH2 SIRT1	O75530 Q15910 Q96EB6	1:1:1	CompleatCORUM	CORUM:1177Compleat:HC1176	15684044
RENT	CDC14A CDC14B SIRT1 WDR75	O60729 Q8IWA0 Q96EB6 Q9UNH5	1:1:1:1	Compleat	Compleat:HC744	10219244
RENT complex	CDC14A CDC14B SIRT1	O60729 Q96EB6 Q9UNH5	1:1:1	Compleat	Compleat:HC2546	10219244

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	32331267

Sequence, Structure & Domains12

Sequences

Length

1,827

Mass

209,453

Sequence

MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIGPLVYSDQYLQISTRLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNNTLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVLLIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAPECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDMLQFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDSWLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNSYGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPEVATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDYMERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVFVKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREIVDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTICMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWGGHWLGDNYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFYPYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRPLLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVRGQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFWDDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS

3D Structural Models

Turn

196..199; 206..209; 308..310; 402..407; 507..509; 524..526; 539..542; 737..739; 765..767; 909..912

Helix

71..73; 85..91; 215..217; 331..342; 350..353; 365..377; 389..391; 393..395; 408..417; 442..450; 480..496; 535..537; 555..558; 559..561; 562..577; 594..596; 609..624; 643..653; 672..675; 680..694; 696..709; 718..721; 725..729; 806..809; 840..843; 868..872

Beta Strand

65..68; 75..77; 99..103; 105..107; 114..121; 123..132; 138..140; 144..154; 157..163; 175..177; 189..195; 200..205; 210..214; 221..223; 226..232; 234..236; 238..244; 247..250; 254..261; 278..284; 291..296; 302..307; 311..319; 321..330; 384..387; 421..426; 459..462; 465..467; 470..473; 500..504; 512..515; 585..588; 599..601; 606..608; 629..631; 637..639; 656..658; 713..715; 732..736; 740..743; 751..757; 762..764; 775..781; 788..792; 795..800; 814..819; 824..832; 835..837; 846..854; 857..865; 874..882; 890..894; 900..902; 905..908; 913..916; 927..930

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

45..55; Low complexity

Domain (FT)

61..110; P-type 1; 932..978; P-type 2

Region

40..61; Disordered; 110..1007; Isomaltase; 1008..1827; Sucrase

Protein Families

Glycosyl hydrolase 31 family

Sequence Similarities

Belongs to the glycosyl hydrolase 31 family.

Clinical Relevance4

Disease Involvement (2)

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (8)

ACARBOSE CELGOSIVIR STREPTOZOCIN SACROSIDASE VOGLIBOSE MIFEPRISTONE DEXAMETHASONE INSULIN, REGULAR, HUMAN

Antibody

HPA011897