Protein detail
GLUT4
Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
Protein symbol GLUT4 | UniProt ID | EVMP score 0.25 |
Frequency 5 | Transmembrane count 12 | Protein classification Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
Protein Class
Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Transmembrane
25..45; Helical; Name=1; 82..102; Helical; Name=2; 112..132; Helical; Name=3; 143..163; Helical; Name=4; 172..192; Helical; Name=5; 202..222; Helical; Name=6; 288..308; Helical; Name=7; 324..344; Helical; Name=8; 354..374; Helical; Name=9; 385..405; Helical; Name=10; 418..438; Helical; Name=11; 446..466; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
GLUT4
Gene Description
Solute carrier family 2 member 4
Chromosome
17
Position
7281718-7288257
Frequency
5
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificcervixCell SpecificBergmann gliaSingle-Nuclei Brain SpecificBergmann gliaBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Cellular Component
- GO:0005771 multivesicular body
- GO:0005802 trans-Golgi network
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0009897 external side of plasma membrane
- GO:0012505 endomembrane system
- GO:0012506 vesicle membrane
- GO:0016020 membrane
- GO:0016529 sarcoplasmic reticulum
- GO:0030136 clathrin-coated vesicle
- GO:0030140 trans-Golgi network transport vesicle
- GO:0030315 T-tubule
- GO:0030659 cytoplasmic vesicle membrane
- GO:0032593 insulin-responsive compartment
- GO:0042383 sarcolemma
- GO:0045121 membrane raft
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0098793 presynapse
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-9843745 adipogenesis
- R-hsa-189200 cellular hexose transport
- R-hsa-199991 membrane trafficking
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-381340 transcriptional regulation of white adipocyte differentiation
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-382551 transport of small molecules
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLC2A4 | SGK1 | O00141 | S | 274 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperdbPTMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17382906dbPTM:17382906ProtMapper:17382906 |
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SGK1 | O00141 | GLUT4 | P14672 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:17382906PhosphoSite:17382906SIGNOR:17382906ProtMapper:32470053ProtMapper:17382906 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | R Sequencing | 1 | 38207106 |
Sequence, Structure & Domains
Sequences
Length
509
Mass
54,787
Sequence
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14672-1; Sequence=Displayed; Name=2; IsoId=P14672-2; Sequence=VSP_056331, VSP_056332
Alternative Sequence
342..415; LLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGP -> TAHLWNGPSHWLHLPGCPGGVVGGAGGAPDAPSPGPGGHVWLCHPDDCGSAPAGASSSHELRLHCGHLWLRGIF (in isoform 2); 416..509; Missing (in isoform 2)
3D Structural Models
Turn
166..168; 199..201; 373..376; 398..401; 413..415
Helix
22..43; 49..64; 65..67; 74..98; 101..106; 109..127; 130..132; 136..163; 169..173; 175..189; 202..208; 210..219; 220..222; 227..232; 238..248; 254..269; 275..279; 282..284; 285..299; 303..316; 322..343; 344..346; 350..372; 380..397; 402..410; 416..445; 449..467; 476..482
Beta Strand
192..196
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Motif
489..490; Dileucine internalization motif
Domain (CC)
The dileucine internalization motif is critical for intracellular sequestration.
Region
7..13; Interaction with SRFBP1
Protein Families
- Major facilitator superfamily
- Sugar transporter (TC 2.A.1.1) family
- Glucose transporter subfamily
Sequence Similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Clinical Relevance
Disease Involvement
Diabetes mellitusDisease variant
Related Diseases
Biomarker
Phase 1
Drug Targets
Clinical trial target
Drugs
PRASTERONEADENOVIRUS VECTORSTAUROSPORINEACETYLCYSTEINEISPAGHULA HUSKRETINOIC ACID AGENTPD-98059ACE INHIBITORSOYBEAN SEED OILRECOMBINANT HEPATOCYTE GROWTH FACTOREPIGALLOCATECHIN GALLATERECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEINNYSTATINFRAMYCETINUCN-01LIOTHYRONINEETOPOSIDENULLCURCUMINTROGLITAZONEPENICILLAMINESTREPTOZOCINBETA-ADRENERGIC ANTAGONISTESTRADIOL 3-BENZOATEOMAPATRILATPHENTOLAMINEINDINAVIRGENISTEINEPINEPHRINEALPHA-ADRENERGIC ANTAGONISTTHERAPEUTIC HORMONESORBITOLASPIRINDEXAMETHASONETHERAPEUTIC GLUCOCORTICOIDCLOFIBRATEPROTEASE INHIBITORSOMATROPIN (RECOMBINANT DNA ORIGIN)ESTRADIOL VALERATEHYDROGEN PEROXIDEIRBESARTANMIRTAZAPINERESVERATROLGLIPIZIDEBUTHIONINE SULFOXIMINEINDOMETHACINGLUFOSFAMIDEURIDINEGREEN TEA LEAF EXTRACTGLYBURIDECALCIUM CHANNEL BLOCKERIMATINIBPROGESTERONEWORTMANNINTHEAFLAVINCOLCHICINEPROTEIN SYNTHESIS INHIBITORHEPARINACARBOSEINSULIN, REGULAR, HUMANVERAPAMILFLUORODEOXYGLUCOSE F18LIFTCDDTNF-ALPHAHALOPERIDOL DECANOATE
Antibody
Interaction Protein
ENSG00000204209
Interaction Count
1
Interaction Dataset
intact_biogrid