Protein detail

GLUT4

Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)

Entry name GLUT4	UniProt ID P14672	EVMP confidence score 0.25
Supporting publications (n) 5	Transmembrane count 12	Protein classification Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)

Protein Class (5)

Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (3)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets

Transmembrane

25..45; Helical; Name=1; 82..102; Helical; Name=2; 112..132; Helical; Name=3; 143..163; Helical; Name=4; 172..192; Helical; Name=5; 202..222; Helical; Name=6; 288..308; Helical; Name=7; 324..344; Helical; Name=8; 354..374; Helical; Name=9; 385..405; Helical; Name=10; 418..438; Helical; Name=11; 446..466; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000181856

Entrez Gene Symbol

SLC2A4

Gene Synonym

GLUT4

Gene Description

Solute carrier family 2 member 4

Chromosome

Position

7281718-7288257

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue SpecificcervixCell SpecificBergmann gliaSingle-Nuclei Brain SpecificBergmann gliaBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells

Function & Pathway7

Protein Function (3)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets

Cellular Component (20)

Page 1 of 2

Molecular Function (3)

Biological Process (3)

KEGG (7)

Reactome (8)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence34

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SLC2A4	SGK1	O00141	S	274	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperdbPTMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:17382906 dbPTM:17382906 ProtMapper:17382906

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

Page 3 of 3Previous

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SGK1	O00141	GLUT4	P14672	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	dbPTM:17382906 PhosphoSite:17382906 SIGNOR:17382906 ProtMapper:32470053 ProtMapper:17382906

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ACAP1-CHC-Glut4 complex	ACAP1 CLTC SLC2A4	P14672 Q00610 Q15027	0:0:0	CORUM	CORUM:6080	17664335
	SLC2A4 SMAP2	P14672 Q8WU79	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	R Sequencing	1	38207106

Sequence, Structure & Domains14

Sequences

Length

509

Mass

54,787

Sequence

MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14672-1; Sequence=Displayed; Name=2; IsoId=P14672-2; Sequence=VSP_056331, VSP_056332

Alternative Sequence

342..415; LLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGP -> TAHLWNGPSHWLHLPGCPGGVVGGAGGAPDAPSPGPGGHVWLCHPDDCGSAPAGASSSHELRLHCGHLWLRGIF (in isoform 2); 416..509; Missing (in isoform 2)

3D Structural Models

Turn

166..168; 199..201; 373..376; 398..401; 413..415

Helix

22..43; 49..64; 65..67; 74..98; 101..106; 109..127; 130..132; 136..163; 169..173; 175..189; 202..208; 210..219; 220..222; 227..232; 238..248; 254..269; 275..279; 282..284; 285..299; 303..316; 322..343; 344..346; 350..372; 380..397; 402..410; 416..445; 449..467; 476..482

Beta Strand

192..196

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Motif

489..490; Dileucine internalization motif

Domain (CC)

The dileucine internalization motif is critical for intracellular sequestration.

Region

7..13; Interaction with SRFBP1

Protein Families (3)

Major facilitator superfamily
Sugar transporter (TC 2.A.1.1) family
Glucose transporter subfamily

Sequence Similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Clinical Relevance9

Disease Involvement (2)

Diabetes mellitusDisease variant

Related Diseases

Type 2 diabetes mellitus

Biomarker

Phase 1

Drug Targets

Clinical trial target

Drugs (66)

PRASTERONE ADENOVIRUS VECTOR STAUROSPORINE ACETYLCYSTEINE ISPAGHULA HUSK RETINOIC ACID AGENT PD-98059 ACE INHIBITOR SOYBEAN SEED OIL RECOMBINANT HEPATOCYTE GROWTH FACTOR EPIGALLOCATECHIN GALLATE RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN NYSTATIN FRAMYCETIN UCN-01 LIOTHYRONINE ETOPOSIDE NULL CURCUMIN TROGLITAZONE PENICILLAMINE STREPTOZOCIN BETA-ADRENERGIC ANTAGONIST ESTRADIOL 3-BENZOATE OMAPATRILAT PHENTOLAMINE INDINAVIR GENISTEIN EPINEPHRINE ALPHA-ADRENERGIC ANTAGONIST THERAPEUTIC HORMONE SORBITOL ASPIRIN DEXAMETHASONE THERAPEUTIC GLUCOCORTICOID CLOFIBRATE PROTEASE INHIBITOR SOMATROPIN (RECOMBINANT DNA ORIGIN)ESTRADIOL VALERATE HYDROGEN PEROXIDE IRBESARTAN MIRTAZAPINE RESVERATROL GLIPIZIDE BUTHIONINE SULFOXIMINE INDOMETHACIN GLUFOSFAMIDE URIDINE GREEN TEA LEAF EXTRACT GLYBURIDE CALCIUM CHANNEL BLOCKER IMATINIB PROGESTERONE WORTMANNIN THEAFLAVIN COLCHICINE PROTEIN SYNTHESIS INHIBITOR HEPARIN ACARBOSE INSULIN, REGULAR, HUMAN VERAPAMIL FLUORODEOXYGLUCOSE F18 LIF TCDD TNF-ALPHA HALOPERIDOL DECANOATE

Antibody

CAB016544

Interaction Protein

ENSG00000204209

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications5

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
39835386	Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40928027	Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.	No abstract available