Protein detail
IDE
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Protein symbol IDE | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count | Protein classification EnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins |
Basic Information
Protein Names
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Protein Class
EnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted intracellular proteins
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Description
Insulin degrading enzyme
Chromosome
10
Position
92451684-92574096
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificlower rhombic lipBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0001618 virus receptor activity
- GO:0004175 endopeptidase activity
- GO:0004222 metalloendopeptidase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008270 zinc ion binding
- GO:0042277 peptide binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0043559 insulin binding
Biological Process
Reactome
- R-hsa-5688426 deubiquitination
- R-hsa-77387 insulin receptor recycling
- R-hsa-9033241 peroxisomal protein import
- R-hsa-597592 post translational protein modification
- R-hsa-9609507 protein localization
- R-hsa-74752 signaling by insulin receptor
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-5689880 ub specific processing proteases
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| m16_metallopeptidase | secreted_peptidase | OmniPath | No | No | Yes | No | No |
| secreted_enzyme | secreted_enzyme | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | DGIdb | No | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IDE | P14735 | INS | P01308 | Yes | No | Yes | SIGNORHPRDHINTIntActDIP | HINT:19321446HINT:29273204HPRD:11145591HPRD:17051221HINT:17051221IntAct:17051221HINT:29596046SIGNOR:29596046DIP:17051221 |
Protein Complex Composition
26 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IDEINS | P01308P14735 | 2:2 | PDB | PDB:7rziPDB:7rzePDB:2g54PDB:5cjoPDB:2wc0PDB:7rzfPDB:6b3qPDB:2g56PDB:5wobPDB:2wbyPDB:6bfc | ||
| IDEIGF2 | P01344P14735 | 2:2 | PDB | PDB:3e4z | ||
| APPIDE | P05067P14735 | 2:2 | PDB | PDB:2g47PDB:4m1cPDB:2wk3 | ||
| IDEUBC | P0CG48P14735 | 2:2 | PDB | PDB:3ofi | ||
| IDEP0DOX5P0DOX7 | P0DOX5P0DOX7P14735 | 2:2:2 | PDB | PDB:6bf7PDB:6bf9 | ||
| IDEP0DOX5Q6GMX0 | P0DOX5P14735Q6GMX0 | 2:2:2 | PDB | PDB:6b7z | ||
| CCL3IDE | P10147P14735 | 2:2 | PDB | PDB:3h44 | ||
| IAPPIDE | P10997P14735 | 2:2 | PDB | PDB:3hgzPDB:2g48 | ||
| ATRCHAF1AHMGB2IDEIFIH1MLH1MSH2MSH3MSH6PCNAPRKDCRPA1RPA2RPA4XPA | P12004P14735P15927P20585P23025P26583P27694P40692P43246P52701P78527Q13111Q13156Q13535Q9BYX4 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9546 | ||
| CCL4IDE | P13236P14735 | 2:2 | PDB | PDB:4ral |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 32331267 |
Sequence, Structure & Domains
Sequences
Length
1,019
Mass
117,968
Sequence
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14735-1; Sequence=Displayed; Name=2; IsoId=P14735-2; Sequence=VSP_044303
Alternative Sequence
1..555; Missing (in isoform 2)
3D Structural Models
Turn
133..135; 326..328; 441..443; 449..454; 486..488; 494..496; 824..827
Helix
96..98; 106..113; 114..116; 126..132; 155..157; 158..166; 167..169; 176..194; 197..207; 214..216; 223..226; 228..232; 237..248; 251..253; 264..275; 295..297; 323..325; 330..338; 346..352; 381..385; 387..404; 408..423; 430..440; 446..448; 461..468; 473..475; 483..485; 507..514; 581..583; 587..613; 638..650; 656..672; 673..675; 678..690; 697..704; 709..721; 735..753; 760..762; 802..823; 856..876; 879..894; 900..912; 920..928; 933..943; 995..1000
Beta Strand
47..50; 63..69; 74..79; 84..93; 101..104; 118..121; 123..125; 137..142; 147..154; 254..262; 276..278; 298..304; 307..309; 312..319; 359..367; 370..378; 477..481; 499..504; 549..553; 555..563; 565..567; 570..579; 584..586; 616..623; 626..635; 691..693; 722..732; 775..782; 787..799; 831..840; 843..854; 945..947; 949..951; 952..959; 990..992
3D Structure
Electron microscopy (14); X-ray crystallography (47)
Domain & Motif Annotations
Motif
853..858; SlyX motif
Domain (CC)
The SlyX motif may be involved in the non-conventional secretion of the protein.
Protein Families
Peptidase M16 family
Sequence Similarities
Belongs to the peptidase M16 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 2; Approved
Drug Targets
FDA approved drug targets
Antibody
Interaction Protein
ENSG00000089163
Interaction Count
1
Interaction Dataset
intact_biogrid