Protein detail
GPIX
Platelet glycoprotein IX (GP-IX) (GPIX) (Glycoprotein 9) (CD antigen CD42a)
Entry name GPIX | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification CD markersDisease related genesHuman disease related genesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Platelet glycoprotein IX (GP-IX) (GPIX) (Glycoprotein 9) (CD antigen CD42a)
Protein Class (4)
CD markersDisease related genesHuman disease related genesPredicted membrane proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- CD markers
Transmembrane
148..168; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CD42aGPIX
Gene Description
Glycoprotein IX platelet
Chromosome
3
Position
129060779-129062406
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway8
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- CD markers
Cellular Component (2)
Molecular Function
Biological Process (3)
KEGG (3)
Reactome (13)
- R-hsa-9673221 defective f9 activation
- R-hsa-9668250 defective factor ix causes hemophilia b
- R-hsa-9651496 defects of contact activation system cas and kallikrein kinin system kks
- R-hsa-9823587 defects of platelet adhesion to exposed collagen
- R-hsa-9671793 diseases of hemostasis
- R-hsa-9845620 enhanced binding of gp1ba variant to vwf multimer collagen
- R-hsa-140877 formation of fibrin clot clotting cascade
- R-hsa-430116 gp1b ix v activation signalling
- R-hsa-109582 hemostasis
- R-hsa-140837 intrinsic pathway of fibrin clot formation
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Canonical Pathways (3)
- M82 Pid ret pathway
- M62 Pid ephb fwd pathway
- M92 Pid angiopoietin receptor pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence40
Ligand-Receptor Signaling (36)
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GPIb-IX-V complex | GP1BAGP1BBGP5GP9 | P07359P13224P14770P40197 | 1:1:1:1 | CellChatDBSIGNORComplexPortal | PDB:3rezSIGNOR:SIGNOR-C270intact:EBI-10727454 | 25297919186882351475529223336709 |
| GP1BAGP1BBGP9 | P07359P13224P14770 | 1:4:2 | PDB | PDB:8wfs | ||
| GP5GP9 | P14770P40197 | 0:0 | Cellinker |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 32331267 |
Sequence, Structure & Domains9
Sequences
Length
177
Mass
19,046
Sequence
MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD
3D Structural Models
Turn
30..32; 68..73; 117..119; 129..133
Helix
91..93; 94..101; 105..110; 147..161
Beta Strand
24..29; 33..37; 55..57; 79..81; 113..116
3D Structure
Electron microscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Repeat
60..83; LRR
Domain (FT)
17..51; LRRNT; 85..137; LRRCT
Clinical Relevance2
Disease Involvement (2)
Bernard Soulier syndromeDisease variant
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |