Protein detail
IL1R1
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
Protein symbol IL1R1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
Protein Class
Cancer-related genesCD markersEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- CD markers
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Transmembrane
337..356; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD121AD2S1473IL1RIL1RA
Gene Description
Interleukin 1 receptor type 1
Chromosome
2
Position
102064544-102179874
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificCytotrophoblasts
Function & Pathway
Protein Function
- CD markers
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
- GO:0002020 protease binding
- GO:0003953 NAD+ nucleosidase activity
- GO:0004888 transmembrane signaling receptor activity
- GO:0004908 interleukin-1 receptor activity
- GO:0004909 interleukin-1, type I, activating receptor activity
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005515 protein binding
- GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663205 infectious disease
- R-hsa-6783783 interleukin 10 signaling
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9020702 interleukin 1 signaling
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9679506 sars cov infections
- R-hsa-449147 signaling by interleukins
- R-hsa-9824446 viral infection pathways
Canonical Pathways
M266 Pid ncadherin pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IL1R1 | CDC42BPA | Q5VT25 | T | 556 | phosphorylation | KEA | KEA:17570479 |
| IL1R1 | PRKCA | P17252 | T | 556 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
72 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
Regulatory Interaction Network
14 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TRAF6 | Q9Y4K3 | IL1R1 | P14778 | Yes | No | Yes | NetPathSIGNORCui2007HINTInnateDBSPIKE_LC | InnateDB:16286016HINT:12242293InnateDB:16354686SIGNOR:19232518SPIKE_LC:17145710HINT:12609980InnateDB:15866876NetPath:12242293HINT:16354686HINT:16286016HINT:16286467SPIKE_LC:16286467InnateDB:12609980InnateDB:12242293 |
| IL1R1 | P14778 | MK10 | P53779 | Yes | Yes | No | SIGNOR | SIGNOR:9625767 |
| IL1R1 | P14778 | MK08 | P45983 | Yes | Yes | No | SIGNOR | SIGNOR:9625767 |
| IL1R1 | P14778 | MK09 | P45984 | Yes | Yes | No | SIGNOR | SIGNOR:9625767 |
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Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL1_receptor | IL1BIL1R1IL1RAP | P01584P14778Q9NPH3 | 2:2:2 | CellPhoneDBComplexPortalPDB | intact:EBI-52378199PDB:1ITBPDB:4depintact:EBI-11896079PDB:4GAFCellPhoneDB:IL1_receptorPDB:4DEP | 308935903128132027264686238476212853417414755292333912833526973928495184 |
| Interleukin-1 antagonist complex | IL1R1IL1RN | P14778P18510 | 1:1 | ComplexPortalPDB | PDB:1ILRintact:EBI-52377458PDB:1iraPDB:1IRA | 3089359031281320272646862384762128534174147552923339128328495184 |
| Precursor interleukin-1 alpha-soluble receptor type 1 complex | IL1AIL1R1IL1RAP | P01583P14778Q9NPH3 | 1:1:1 | ComplexPortal | PDB:2KKIPDB:2ILA | 27264686334823372384762114755292333912832665665829247991 |
| IL1BIL1R1 | P01584P14778 | 1:1 | PDB | PDB:1itbPDB:4gaf | ||
| IL1R1IL1RAP | P14778Q9NPH3 | 0:0 | Guide2PharmaCellChatDBKEGG-MEDICUSICELLNETCellinkerSPIKE | 2433202920959797 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32331267 |
Sequence, Structure & Domains
Sequences
Length
569
Mass
65,402
Sequence
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG
3D Structural Models
Turn
151..153
Helix
48..50; 88..90; 124..126; 146..148; 188..190; 287..289; 303..306
Beta Strand
24..27; 32..35; 40..43; 56..59; 72..77; 80..83; 92..97; 100..102; 105..114; 120..122; 127..133; 135..137; 138..141; 159..162; 171..177; 180..183; 192..202; 205..218; 227..230; 233..237; 240..242; 244..252; 256..262; 272..281; 290..300; 310..316; 319..328
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
556..569; Basic and acidic residues
Domain (CC)
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Domain (FT)
23..110; Ig-like C2-type 1; 118..210; Ig-like C2-type 2; 226..328; Ig-like C2-type 3; 383..538; TIR
Region
540..569; Disordered
Protein Families
Interleukin-1 receptor family
Sequence Similarities
Belongs to the interleukin-1 receptor family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Related Diseases
Biomarker
Approved; Phase 3
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000136689ENSG00000175104ENSG00000196083
Interaction Count
3
Interaction Dataset
intact_biogrid