Protein detail

IL1R1

Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]

Protein symbol IL1R1	UniProt ID P14778	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Cancer-related genesCD markersEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteinsTransporters

Protein Function

CD markers
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted secreted proteins
ENZYME proteins:Hydrolases
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Transmembrane

337..356; Helical

Transmembrane Count

Ensembl

ENSG00000115594

Entrez Gene Symbol

IL1R1

Gene Synonym

CD121AD2S1473IL1RIL1RA

Gene Description

Interleukin 1 receptor type 1

Chromosome

Position

102064544-102179874

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificCytotrophoblasts

Function & Pathway

Protein Function

CD markers
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted secreted proteins
ENZYME proteins:Hydrolases
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M266 Pid ncadherin pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL1R1	CDC42BPA	Q5VT25	T	556	phosphorylation	KEA	KEA:17570479
IL1R1	PRKCA	P17252	T	556	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

72 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellCall	No	Yes	Yes	Yes	No
receptor	receptor	iTALK	No	Yes	Yes	Yes	No
cytokine	receptor	iTALK	No	Yes	Yes	Yes	No
receptor	receptor	Almen2009	No	Yes	Yes	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No
receptor	receptor	EMBRACE	No	Yes	Yes	Yes	No
interleukin	receptor	HGNC	No	Yes	Yes	Yes	No
tir_domain	receptor	HGNC	No	Yes	Yes	Yes	No
receptor	receptor	HGNC	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No

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Regulatory Interaction Network

14 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL1A	P01583	IL1R1	P14778	Yes	Yes	No	iTALKKirouac2010SIGNORSignaLink3InnateDBUniProt_LRdbHPMR_talklrHPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	SignaLink3:9565970 CellTalkDB:2946959 InnateDB:8142597 LRdb:2946959 SPIKE:7692435 SPIKE_LC:19479203 SignaLink3:2946959 SPIKE_LC:7692435 NetPath:7775431 SIGNOR:9565970 NetPath:2946959 SignaLink3:23331499 SPIKE:19479203 SIGNOR:7964161Baccin2019:29469592946959HPRD:2946959 connectomeDB2020:2946959 NetPath:17507369
IRAK2	O43187	IL1R1	P14778	Yes	Yes	No	WangNetPathPhosphoPointSIGNORHPRDHINTInnateDBSPIKE_LCSPIKE	HPRD:9374458 InnateDB:9374458 HINT:9374458 SPIKE:10854325 SPIKE_LC:10854325 InnateDB:12659850 SIGNOR:35486320 NetPath:9374458 HINT:12659850 HPRD:12659850
IL1R1	P14778	IRAK2	O43187	Yes	Yes	No	WangNetPathHPRDHINTSignaLink3InnateDBSPIKE_LCSPIKE	HPRD:9374458 InnateDB:9374458 HINT:9374458 SPIKE:10854325 SPIKE_LC:10854325 InnateDB:12659850 SignaLink3:9374458 NetPath:9374458 SignaLink3:23331499 HINT:12659850 HPRD:12659850
IL1R1	P14778	IRAK1	P51617	Yes	Yes	No	WangNetPathHINTSignaLink3InnateDBDIPSPIKE_LCSPIKE	SPIKE_LC:16024789 InnateDB:15866876 DIP:8599092 HINT:9430229 HINT:9374458 SignaLink3:14625308 HINT:8599092 HINT:16286016 NetPath:12242293 SignaLink3:23331499 HINT:12242293 InnateDB:9374458 NetPath:9430229 HINT:12609980 NetPath:16024789 InnateDB:15905496 InnateDB:9430229 InnateDB:16286016 InnateDB:12609980 SPIKE:16024789 InnateDB:12242293
IL1RA	P18510	IL1R1	P14778	Yes	No	Yes	iTALKICELLNETSIGNORHINTInnateDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	SPIKE_LC:17145710 Cellinker:11641511 SPIKE:17145710 CellTalkDB:11641511 InnateDB:8142597 LRdb:11641511 SPIKE:9062194 ICELLNET:20959797 NetPath:7589429 SPIKE:7589429 IntAct:9062194 Baccin2019:11641511 SPIKE_LC:7589429 HPRD:9062194 SIGNOR:2876877LRdb:91HPRD:11641511 SPIKE_LC:9062194 HINT:33961781 Cellinker:9062194 Baccin2019:9062194 HINT:9062194 BioGRID:9062194 IntAct:33961781 ICELLNET:24332029 connectomeDB2020:9062194
IL1B	P01584	IL1R1	P14778	Yes	Yes	No	iTALKSIGNORHINTSignaLink3InnateDBUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbMacrophageNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	Baccin2019:9062193 HINT:23431173 SPIKE_LC:17145710 CellTalkDB:9062193 NetPath:7775431 SPIKE:17145710 SIGNOR:9625767 SignaLink3:9062193 Baccin2019:9820540 HPRD:9062193 InnateDB:8142597 Lit-BM-17:7878046Baccin2019:62193LRdb:62193HINT:9062193 NetPath:2946959 SignaLink3:23331499 SIGNOR:24166242 LRdb:9820540 SPIKE:9062193connectomeDB2020:62193Macrophage:9062193 Lit-BM-17:9062193 HINT:7878046 connectomeDB2020:9820540 HINT:22426547 SPIKE_LC:9062193 connectomeDB2020:9062193 LRdb:9062193
IL1R1	P14778	IL1AP	Q9NPH3	Yes	Yes	Yes	NetPathSIGNORHPRDHINTInnateDBWang	HINT:9371760 HINT:15866876 NetPath:9430229 SIGNOR:10854325 HPRD:9371760 InnateDB:9371760 NetPath:10854325 InnateDB:15044087 HINT:20802483 HINT:22426547 NetPath:7775431 InnateDB:9430229 InnateDB:15866876 NetPath:17507369
IL1AP	Q9NPH3	IL1R1	P14778	Yes	Yes	Yes	NetPathSIGNORHPRDHINTSignaLink3InnateDBCellinkerWang	HINT:9371760 HINT:15866876 NetPath:9430229 HPRD:9371760 InnateDB:9371760 NetPath:10854325 Cellinker:11756486 HINT:20802483 HINT:22426547 InnateDB:15044087 NetPath:7775431 SignaLink3:12530978 SignaLink3:23331499 InnateDB:9430229 InnateDB:15866876 SIGNOR:12530978 SignaLink3:9371760 NetPath:17507369
IL1R1	P14778	P85A	P27986	Yes	Yes	No	WangHPRDNetPathSignaLink3	HPRD:9360994 SignaLink3:9360994 SignaLink3:23331499 NetPath:9360994 HPRD:10373529
IL1R1	P14778	MYD88	Q99836	Yes	Yes	No	MacrophageNetPathSIGNORHPRDHINTInnateDBWang	InnateDB:16286016 InnateDB:16354686 NetPath:9430229 HINT:19940113 HINT:12609980 InnateDB:12659850 InnateDB:15905496 NetPath:17507369 InnateDB:19940113 HINT:16354686 InnateDB:9430229 HINT:12659850 HINT:16286016 InnateDB:15866876 Macrophage:17507369 InnateDB:12609980 SIGNOR:10217414 HPRD:12659850

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Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL1_receptor	IL1B IL1R1 IL1RAP	P01584 P14778 Q9NPH3	2:2:2	CellPhoneDBComplexPortalPDB	intact:EBI-52378199PDB:1ITBPDB:4depintact:EBI-11896079PDB:4GAFCellPhoneDB:IL1_receptorPDB:4DEP	30893590 31281320 27264686 23847621 28534174 14755292 33391283 35269739 28495184
Interleukin-1 antagonist complex	IL1R1 IL1RN	P14778 P18510	1:1	ComplexPortalPDB	PDB:1ILRintact:EBI-52377458PDB:1iraPDB:1IRA	30893590 31281320 27264686 23847621 28534174 14755292 33391283 28495184
Precursor interleukin-1 alpha-soluble receptor type 1 complex	IL1A IL1R1 IL1RAP	P01583 P14778 Q9NPH3	1:1:1	ComplexPortal	PDB:2KKIPDB:2ILA	27264686 33482337 23847621 14755292 33391283 26656658 29247991
	IL1B IL1R1	P01584 P14778	1:1	PDB	PDB:1itbPDB:4gaf
	IL1R1 IL1RAP	P14778 Q9NPH3	0:0	Guide2PharmaCellChatDBKEGG-MEDICUSICELLNETCellinkerSPIKE		24332029 20959797

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	32331267

Sequence, Structure & Domains

Sequences

Length

569

Mass

65,402

Sequence

MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG

3D Structural Models

Turn

151..153

Helix

48..50; 88..90; 124..126; 146..148; 188..190; 287..289; 303..306

Beta Strand

24..27; 32..35; 40..43; 56..59; 72..77; 80..83; 92..97; 100..102; 105..114; 120..122; 127..133; 135..137; 138..141; 159..162; 171..177; 180..183; 192..202; 205..218; 227..230; 233..237; 240..242; 244..252; 256..262; 272..281; 290..300; 310..316; 319..328

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

556..569; Basic and acidic residues

Domain (CC)

The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Domain (FT)

23..110; Ig-like C2-type 1; 118..210; Ig-like C2-type 2; 226..328; Ig-like C2-type 3; 383..538; TIR

Region

540..569; Disordered

Protein Families

Interleukin-1 receptor family

Sequence Similarities

Belongs to the interleukin-1 receptor family.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantFDA approved drug targets

Related Diseases

Rheumatoid arthritis COVID-19

Biomarker

Approved; Phase 3

Drug Targets

FDA approved drug targets

Drugs

RECOMBINANT INTERLEUKIN-1 EPOETIN ALFA ANAKINRA DEHYDRATED ALCOHOL GENISTEIN ALUM, POTASSIUM AS101 MEDI-8968 VITAMIN D AMG-108 TRETINOIN THERAPEUTIC CORTICOSTEROID ADJUVANT

Antibody

HPA001237 HPA005823 CAB007779 HPA029560

Interaction Protein

ENSG00000136689ENSG00000175104ENSG00000196083

Interaction Count

Interaction Dataset

intact_biogrid