Protein detail

IL2RB

Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)

Protein symbol
IL2RB
UniProt ID
P14784
EVMP score
0.25
Frequency
1
Transmembrane count
1
Protein classification
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters
Basic Information
Protein Names
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Protein Class
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters
Protein Function
  • CD markers
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Disease related genes
  • FDA approved drug targets:Biotech drugs
Transmembrane
241..265; Helical
Transmembrane Count
1
Ensembl
ENSG00000100385
Entrez Gene Symbol
IL2RB
Gene Synonym
CD122IL15RB
Gene Description
Interleukin 2 receptor subunit beta
Chromosome
22
Position
37118666-37175118
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificEpididymal efferent duct absorptive cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
  • CD markers
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Cancer-related genes:Candidate cancer biomarkers
  • Transporters:Accessory Factors Involved in Transport
  • Disease related genes
  • FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

15 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
IL2RBLCKP06239Y384phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:2047859KEA:10214954phosphoELM:10214954ProtMapper:10214954phosphoELM:2047859SIGNOR:10214954
IL2RBLCKP06239Y418phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperphosphoELM:10214954SIGNOR:10214954KEA:10214954ProtMapper:10214954
IL2RBLCKP06239Y387phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:2047859KEA:10214954phosphoELM:10214954ProtMapper:10214954phosphoELM:2047859SIGNOR:10214954
IL2RBLCKP06239Y536phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperphosphoELM:10214954SIGNOR:10214954KEA:10214954ProtMapper:10214954
IL2RBLCKP06239Y381phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:2047859KEA:10214954phosphoELM:10214954ProtMapper:10214954phosphoELM:2047859SIGNOR:10214954
IL2RBJAK1P23458Y536phosphorylationSIGNOR_ProtMapperSIGNORProtMapperProtMapper:8700888SIGNOR:8700888
IL2RBJAK1P23458Y418phosphorylationSIGNOR_ProtMapperSIGNORProtMapperProtMapper:8700888SIGNOR:8700888
IL2RBJAK1P23458Y364phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperHPRD:8700888KEA:7499411SIGNOR:8700888ProtMapper:8700888KEA:8643566KEA:8700888
IL2RBSRCP12931Y418phosphorylationLi2012
IL2RBSRCP12931Y536phosphorylationLi2012
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Ligand-Receptor Signaling

58 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorCellPhoneDBNoYesNoYesNo
receptorreceptorGO_IntercellNoYesNoYesNo
receptorreceptorHPMRNoYesNoYesNo
receptorreceptorICELLNETNoYesNoYesNo
receptorreceptorCellTalkDBNoYesNoYesNo
receptorreceptorSurfaceomeNoYesNoYesNo
receptorreceptorRamilowski2015NoYesNoYesNo
receptorreceptorGuide2PharmaNoYesNoYesNo
receptorreceptorLRdbNoYesNoYesNo
receptorreceptorBaccin2019NoYesNoYesNo
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Regulatory Interaction Network

8 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PTN6P29350IL2RBP14784YesNoYesWangNetPathSIGNORHPRDInnateDBSPIKE_LCSPIKENetPath:9520455HPRD:9520455SPIKE_LC:9973481SPIKE:9520455SPIKE_LC:9520455InnateDB:9520455SPIKE:9973481SIGNOR:9520455
LCKP06239IL2RBP14784YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteNetPathSPIKE_LCSPIKEPhosphoSite:10214954SIGNOR:10214954SPIKE_LC:2047859PhosphoSite:18348982SPIKE:16189514SPIKE:10214954KEA:2047859KEA:10214954phosphoELM:10214954PhosphoSite:10602027SPIKE_LC:10214954SPIKE:2047859HPRD:10214954ProtMapper:10214954NetPath:2047859HPRD:2047859PhosphoSite:12200137phosphoELM:2047859SPIKE_LC:16189514
IL2RBP14784JAK1P23458YesYesNoWangKEGG-MEDICUSNetPathSIGNORHPRDHINTBioGRIDInnateDBDIPSPIKE_LCSPIKEBioGRID:9553136InnateDB:12133952SIGNOR:24737791HINT:7973659HINT:10373548DIP:7973658HPRD:8700888SPIKE_LC:7973657HINT:7973657InnateDB:7973657HPRD:7973659InnateDB:8041779HINT:8700888BioGRID:9774657InnateDB:10373548SPIKE:7973657HINT:8041779HINT:12133952HPRD:12133952NetPath:7973659
JAK1P23458IL2RBP14784YesYesNoHPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAInnateDBDIPHPRDWangHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEASIGNOR_ProtMapperNetPathSPIKE_LCSPIKEBioGRID:9553136InnateDB:12133952HPRD-phos:8700888HINT:7973659HINT:10373548KEA:8643566DIP:7973658HPRD:8700888SPIKE_LC:8700888SIGNOR:8700888SPIKE_LC:7973657iPTMnet:8700888HINT:7973657InnateDB:7973657HPRD:7973659InnateDB:8041779HINT:8700888KEA:8700888BioGRID:9774657InnateDB:10373548SPIKE:7973657KEA:7499411SPIKE:8700888HINT:8041779ProtMapper:8700888HINT:12133952HPRD:12133952NetPath:7973659
IL2P60568IL2RBP14784YesYesNoiTALKSIGNORHINTInnateDBDIPUniProt_LRdbHPMR_talklrHPMRHPRD_LRdbtalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKEHPRD:8049354HINT:16477002HPRD:11035066InnateDB:3098894connectomeDB2020:15265897DIP:22446627HINT:11035066HPMR:15933202Baccin2019:15265897InnateDB:1940342CellTalkDB:15265897DIP:8006584HINT:22446627HINT:3095922IntAct:22446627Baccin2019:11035066HINT:28405498HPMR:15265897InnateDB:8568232connectomeDB2020:11035066LRdb:11035066SIGNOR:16477002NetPath:8260650SPIKE:3095922Baccin2019:8049354InnateDB:3095922HINT:8049354HINT:3098894HINT:1940342SPIKE_LC:3095922connectomeDB2020:8049354HINT:15178252HINT:16293754LRdb:15265897InnateDB:15178252NetPath:3116143LRdb:8049354
IL2RBP14784SHC1P29353YesYesNoWangNetPathSIGNORELMHPRDLMPIDSPIKE_LCSPIKEHPRD:8294403SPIKE:16189514NetPath:8700888ELM:8643566SIGNOR:24737791HPRD:10602027SPIKE:10602027LMPID:8643566SPIKE_LC:16189514SPIKE_LC:10602027
I15RAQ13261IL2RBP14784YesYesNoHPRDWangSIGNORHPRD:7641685SIGNOR:17709786
MK03P27361IL2RBP14784YesNoNoiPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapperPhosphoSite:26152718

Protein Complex Composition

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
IL2-IL2RA-IL2RB complexIL2IL2RAIL2RBP01589P14784P605681:1:1CompleatCORUMCompleat:HC1334CORUM:17072303462
IL2RBP147842PDBPDB:7s2s

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometryR Sequencing3407409863841684132396726
Sequence, Structure & Domains

Sequences

Length
551
Mass
61,117
Sequence
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV

3D Structural Models

Turn
178..180
Helix
126..128; 159..162
Beta Strand
33..38; 40..49; 51..53; 59..65; 72..75; 77..89; 104..112; 115..124; 136..143; 148..153; 164..172; 183..186; 191..195; 203..212; 227..230
3D Structure
X-ray crystallography (7)

Domain & Motif Annotations

Motif
220..224; WSXWS motif; 278..286; Box 1 motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.
Domain (FT)
134..234; Fibronectin type-III
Region
389..416; Disordered; 432..486; Disordered
Protein Families
  • Type I cytokine receptor family
  • Type 4 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Related Diseases
Bladder cancerBrain cancerColorectal cancerHead and neck cancerHuman immunodeficiency virus diseaseMelanomaRenal cell carcinomaSarcomaSolid tumour/cancer
Biomarker
Phase 1/2; Phase 2; Phase 1; Phase 3
Drug Targets
FDA approved drug targets
Drugs
BEMPEGALDESLEUKINBASILIXIMABLEUKOCYTE INTERLEUKINMIK-BETA-1RECOMBINANT INTERLEUKIN-2NULLDACLIZUMABDENILEUKIN DIFTITOXALDESLEUKINRECOMBINANT HUMAN INTERLEUKIN-15PEGENZILEUKINHUMIK-BETA-1SIMLUKAFUSP ALFA
Antibody
HPA062657