EV MemProt Atlas

Basic Information

Protein Names

Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)

Protein Class

Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters

Protein Function

CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

241..265; Helical

Transmembrane Count

1

Ensembl

ENSG00000100385

Entrez Gene Symbol

IL2RB

Gene Synonym

CD122IL15RB

Gene Description

Interleukin 2 receptor subunit beta

Chromosome

22

Position

37118666-37175118

Frequency

1

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificEpididymal efferent duct absorptive cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

15 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL2RB	LCK	P06239	Y	384	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:2047859 KEA:10214954 phosphoELM:10214954 ProtMapper:10214954 phosphoELM:2047859 SIGNOR:10214954
IL2RB	LCK	P06239	Y	418	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	phosphoELM:10214954 SIGNOR:10214954 KEA:10214954 ProtMapper:10214954
IL2RB	LCK	P06239	Y	387	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:2047859 KEA:10214954 phosphoELM:10214954 ProtMapper:10214954 phosphoELM:2047859 SIGNOR:10214954
IL2RB	LCK	P06239	Y	536	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	phosphoELM:10214954 SIGNOR:10214954 KEA:10214954 ProtMapper:10214954
IL2RB	LCK	P06239	Y	381	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:2047859 KEA:10214954 phosphoELM:10214954 ProtMapper:10214954 phosphoELM:2047859 SIGNOR:10214954
IL2RB	JAK1	P23458	Y	536	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:8700888 SIGNOR:8700888
IL2RB	JAK1	P23458	Y	418	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:8700888 SIGNOR:8700888
IL2RB	JAK1	P23458	Y	364	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	HPRD:8700888 KEA:7499411 SIGNOR:8700888 ProtMapper:8700888 KEA:8643566 KEA:8700888
IL2RB	SRC	P12931	Y	418	phosphorylation	Li2012
IL2RB	SRC	P12931	Y	536	phosphorylation	Li2012

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Ligand-Receptor Signaling

58 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTN6	P29350	IL2RB	P14784	Yes	No	Yes	WangNetPathSIGNORHPRDInnateDBSPIKE_LCSPIKE	NetPath:9520455 HPRD:9520455 SPIKE_LC:9973481 SPIKE:9520455 SPIKE_LC:9520455 InnateDB:9520455 SPIKE:9973481 SIGNOR:9520455
LCK	P06239	IL2RB	P14784	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteNetPathSPIKE_LCSPIKE	PhosphoSite:10214954 SIGNOR:10214954 SPIKE_LC:2047859 PhosphoSite:18348982 SPIKE:16189514 SPIKE:10214954 KEA:2047859 KEA:10214954 phosphoELM:10214954 PhosphoSite:10602027 SPIKE_LC:10214954 SPIKE:2047859 HPRD:10214954 ProtMapper:10214954 NetPath:2047859 HPRD:2047859 PhosphoSite:12200137 phosphoELM:2047859 SPIKE_LC:16189514
IL2RB	P14784	JAK1	P23458	Yes	Yes	No	WangKEGG-MEDICUSNetPathSIGNORHPRDHINTBioGRIDInnateDBDIPSPIKE_LCSPIKE	BioGRID:9553136 InnateDB:12133952 SIGNOR:24737791 HINT:7973659 HINT:10373548 DIP:7973658 HPRD:8700888 SPIKE_LC:7973657 HINT:7973657 InnateDB:7973657 HPRD:7973659 InnateDB:8041779 HINT:8700888 BioGRID:9774657 InnateDB:10373548 SPIKE:7973657 HINT:8041779 HINT:12133952 HPRD:12133952 NetPath:7973659
JAK1	P23458	IL2RB	P14784	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAInnateDBDIPHPRDWangHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEASIGNOR_ProtMapperNetPathSPIKE_LCSPIKE	BioGRID:9553136 InnateDB:12133952 HPRD-phos:8700888 HINT:7973659 HINT:10373548 KEA:8643566 DIP:7973658 HPRD:8700888 SPIKE_LC:8700888 SIGNOR:8700888 SPIKE_LC:7973657 iPTMnet:8700888 HINT:7973657 InnateDB:7973657 HPRD:7973659 InnateDB:8041779 HINT:8700888 KEA:8700888 BioGRID:9774657 InnateDB:10373548 SPIKE:7973657 KEA:7499411 SPIKE:8700888 HINT:8041779 ProtMapper:8700888 HINT:12133952 HPRD:12133952 NetPath:7973659
IL2	P60568	IL2RB	P14784	Yes	Yes	No	iTALKSIGNORHINTInnateDBDIPUniProt_LRdbHPMR_talklrHPMRHPRD_LRdbtalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	HPRD:8049354 HINT:16477002 HPRD:11035066 InnateDB:3098894 connectomeDB2020:15265897 DIP:22446627 HINT:11035066 HPMR:15933202 Baccin2019:15265897 InnateDB:1940342 CellTalkDB:15265897 DIP:8006584 HINT:22446627 HINT:3095922 IntAct:22446627 Baccin2019:11035066 HINT:28405498 HPMR:15265897 InnateDB:8568232 connectomeDB2020:11035066 LRdb:11035066 SIGNOR:16477002 NetPath:8260650 SPIKE:3095922 Baccin2019:8049354 InnateDB:3095922 HINT:8049354 HINT:3098894 HINT:1940342 SPIKE_LC:3095922 connectomeDB2020:8049354 HINT:15178252 HINT:16293754 LRdb:15265897 InnateDB:15178252 NetPath:3116143 LRdb:8049354
IL2RB	P14784	SHC1	P29353	Yes	Yes	No	WangNetPathSIGNORELMHPRDLMPIDSPIKE_LCSPIKE	HPRD:8294403 SPIKE:16189514 NetPath:8700888 ELM:8643566 SIGNOR:24737791 HPRD:10602027 SPIKE:10602027 LMPID:8643566 SPIKE_LC:16189514 SPIKE_LC:10602027
I15RA	Q13261	IL2RB	P14784	Yes	Yes	No	HPRDWangSIGNOR	HPRD:7641685 SIGNOR:17709786
MK03	P27361	IL2RB	P14784	Yes	No	No	iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:26152718

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL2-IL2RA-IL2RB complex	IL2 IL2RA IL2RB	P01589 P14784 P60568	1:1:1	CompleatCORUM	Compleat:HC1334CORUM:1707	2303462
	IL2RB	P14784	2	PDB	PDB:7s2s

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryR Sequencing	3	40740986 38416841 32396726

Sequence, Structure & Domains

Sequences

Length

551

Mass

61,117

Sequence

MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV

3D Structural Models

Turn

178..180

Helix

126..128; 159..162

Beta Strand

33..38; 40..49; 51..53; 59..65; 72..75; 77..89; 104..112; 115..124; 136..143; 148..153; 164..172; 183..186; 191..195; 203..212; 227..230

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Motif

220..224; WSXWS motif; 278..286; Box 1 motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

Domain (FT)

134..234; Fibronectin type-III

Region

389..416; Disordered; 432..486; Disordered

Protein Families

Type I cytokine receptor family
Type 4 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantFDA approved drug targets

Related Diseases

Bladder cancer Brain cancer Colorectal cancer Head and neck cancer Human immunodeficiency virus disease Melanoma Renal cell carcinoma Sarcoma Solid tumour/cancer

Biomarker

Phase 1/2; Phase 2; Phase 1; Phase 3

Drug Targets

FDA approved drug targets

Drugs

BEMPEGALDESLEUKIN BASILIXIMAB LEUKOCYTE INTERLEUKIN MIK-BETA-1 RECOMBINANT INTERLEUKIN-2 NULL DACLIZUMAB DENILEUKIN DIFTITOX ALDESLEUKIN RECOMBINANT HUMAN INTERLEUKIN-15 PEGENZILEUKIN HUMIK-BETA-1 SIMLUKAFUSP ALFA

Antibody

HPA062657

Protein symbol IL2RB	UniProt ID P14784	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters