Protein detail
GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) (GABAAR subunit alpha-1)
Entry name GBRA1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) (GABAAR subunit alpha-1)
Protein Class (6)
Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
254..274; Helical; 280..301; Helical; 312..333; Helical; 422..441; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
EJM5
Gene Description
Gamma-aminobutyric acid type A receptor subunit alpha1
Chromosome
5
Position
161847063-161899981
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificAdrenal cortex cells
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (13)
- GO:0005886 plasma membrane
- GO:0030659 cytoplasmic vesicle membrane
- GO:0032590 dendrite membrane
- GO:0034707 chloride channel complex
- GO:0043005 neuron projection
- GO:0043197 dendritic spine
- GO:0045202 synapse
- GO:0098794 postsynapse
- GO:0098982 GABA-ergic synapse
- GO:0099634 postsynaptic specialization membrane
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Molecular Function (6)
- GO:0004890 GABA-A receptor activity
- GO:0005254 chloride channel activity
- GO:0008503 benzodiazepine receptor activity
- GO:0016917 GABA receptor activity
- GO:0022851 GABA-gated chloride ion channel activity
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process (3)
KEGG (8)
Reactome (6)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence44
Ligand-Receptor Signaling (35)
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| channels | transporter | Surfaceome | Yes | ||||
| ion_channel | ion_channel | DGIdb | Yes | ||||
| ion_channel | ion_channel | Almen2009 | Yes | ||||
| ligand_gated | ion_channel | Almen2009 | Yes | ||||
| ligand_gated | ion_channel | Surfaceome | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| ion_channel | ion_channel | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCD19 | Q8TAB3 | GBRA1 | P14867 | Yes | Yes | SIGNOR | SIGNOR:29360992 |
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GABA-A (a1-b1-g2) receptor | GABRA1GABRB1GABRG2 | P14867P18505P18507 | 2:2:1 | SIGNORComplexPortal | intact:EBI-48428573SIGNOR:SIGNOR-C330 | 35355020344179301475529229950725 |
| GABA-A receptor (GABRA1GABRB2GABRD) | GABRA1GABRB2GABRD | O14764P14867P47870 | 1:2:2 | CORUMCellChatDBCellPhoneDBComplexPortal | CellPhoneDB:GABA-A_a1b2d_complexCORUM:7462intact:EBI-48423922 | 341533111715999234417930182044871511576814755292274932043680457219766404 |
| GABA-A receptor (GABRA1GABRB2GABRG2) | GABRA1GABRB2GABRG2 | P14867P18507P47870 | 2:1:2 | CellChatDBCellPhoneDBComplexPortalCORUMCompleatPDB | PDB:6X3XPDB:6X3UPDB:8sgoPDB:8si9PDB:9drxPDB:6x3xPDB:6x3wPDB:9CRSPDB:6d6uCORUM:5809PDB:7t0wPDB:8vqyPDB:6X3VPDB:6X40PDB:8sidPDB:8SI9PDB:6x40PDB:9crsPDB:6d6tPDB:6X3TPDB:6x3uintact:EBI-9008426PDB:6x3zPDB:6X3SPDB:8SGOPDB:6x3sPDB:8DD3CellPhoneDB:GABA-A_a1b2g2S_complexPDB:8dd2PDB:7t0zPDB:6x3vPDB:6X3WPDB:8DD2PDB:6D6UPDB:6D6TCompleat:HC3449PDB:8vrnPDB:6X3ZPDB:8dd3PDB:6x3t | 11992121359334263760794034417930147552921879087437892178274932043287948839843743 |
| GABA-A receptoralpha1-beta1-beta2-gamma2 | GABRA1GABRB1GABRB2GABRG2 | P14867P18505P18507P47870 | 1:2:1:1 | ComplexPortalPDB | PDB:9cxdPDB:9CXDintact:EBI-61254168 | 35933426376079403441793014755292378921783287948839843743 |
| GABA-A_a1b2_complex | GABRA1GABRB2 | P14867P47870 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:GABA-A_a1b2_complex | |
| GABRA1 | P14867 | 10 | PDB | PDB:6cduPDB:6d1s | ||
| GABRA1TMEM35A | P14867Q53FP2 | 2:2 | PDB | PDB:9h9e |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryR Sequencing | 1 | 37704453 |
Sequence, Structure & Domains
Sequences
Length
456
Mass
51,802
Sequence
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
3D Structural Models
Turn
50..52; 59..63; 82..85; 171..174; 191..193; 337..339
Helix
39..49; 100..102; 117..119; 202..204; 251..256; 258..270; 271..273; 279..301; 312..336; 419..444
Beta Strand
66..81; 86..98; 109..113; 126..128; 131..133; 139..141; 144..149; 152..165; 177..188; 194..200; 205..208; 216..232; 235..248; 302..304; 346..348
3D Structure
Electron microscopy (76); X-ray crystallography (2)
Domain & Motif Annotations
Domain (CC)
The extracellular domain contributes to synaptic contact formation.; DOMAIN: The GABA-binding pockets are located at the interface between neighboring alpha and beta subunits.; DOMAIN: GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Protein Families (3)
- Ligand-gated ion channel (TC 1.A.9) family
- Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
- GABRA1 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
Clinical Relevance
Disease Involvement (3)
Disease variantEpilepsyFDA approved drug targets
Related Diseases (20)
EpilepsyAcute respiratory distress syndromeAnxiety disorderChronic insomniaChronic painCorneal diseaseCystitisDepressionEpilepsy/seizureFemale pelvic painHeadacheIndeterminate colitisInsomniaLiver vascular disorderMalariaMental/behavioural/neurodevelopmental disorderPostoperative inflammationStatus epilepticusTonus and reflex abnormalityTremor-related disorder
Biomarker
Approved; Discontinued in Phase 3; Phase 2; Discontinued in Phase 1; Investigative; Phase 3
Drug Targets
FDA approved drug targets
Drugs (129)
ZK-93423QUAZEPAMZOPICLONEALPRAZOLAMTRIAZOLAMESTAZOLAMHALAZEPAMMEPHOBARBITALMETHOXYFLURANEBARBITURATEL838417FLUMAZENILACAMPROSATE CALCIUMGABOXADOLISONIPECOTIC ACIDPROGABIDEBUTALBITALISOFLURANEGANAXOLONEESZOPICLONEBUTOBARBITALCLORAZEPATETALBUTALNULLZK93426TEMAZEPAMCHLORDIAZEPOXIDE HYDROCHLORIDEMIDAZOLAM HYDROCHLORIDEBUTABARBITALLORAZEPAMTPA023TBPS[3H]CGS8216PENTOBARBITAL SODIUMFLUDIAZEPAMPHENOBARBITALDESFLURANEETHCHLORVYNOLMETHOHEXITAL SODIUMBREXANOLONEZALEPLONDIAZEPAMCINOLAZEPAMHEXOBARBITALNITRAZEPAMMETHAQUALONE HYDROCHLORIDEOCINAPLONDIMDAZENIL[3H]GABAZINEPRAZEPAMBUTABARBITAL SODIUMCHLORDIAZEPOXIDETHIAMYLAL SODIUMPAGOCLONECENOBAMATEPADSEVONILPROPOFOLTHIAMYLALMEPROBAMATEFLURAZEPAM&ALPHA3IACLONAZEPAMCIPEPOFOLTRICLOFOS SODIUMCLOBAZAMCLOTIAZEPAMMETHYPRYLONETOMIDATEZN2+BICUCULLINEPRIMIDONEMETHOHEXITALSECOBARBITALTETRAHYDRODEOXYCORTICOSTERONEINDIPLONCLORAZEPATE DIPOTASSIUMZOLPIDEM TARTRATE[18F]FLUOROETHYLFLUMAZENILHALOTHANETETRAZEPAMTOPIRAMATESEVOFLURANETHIOPENTAL SODIUMBARBITALPIPERIDINE-4-SULPHONIC ACIDMRK016AMOBARBITALFLUNITRAZEPAMMETHARBITALCHEMBL:CHEMBL2170369ADINAZOLAMTHIOCOLCHICOSIDEOXAZEPAM[3H]MUSCIMOL&ALPHA5IARO15-4513CHLORMETHIAZOLEREMIMAZOLAMPICROTOXINLOREDIPLONRO4938581RO19-4603[35S]TBPSENFLURANEREMIMAZOLAM BESYLATEZK93423DEHYDRATED ALCOHOLBROMAZEPAMADIPIPLONDMCMTP003RESEQUINILABP-700ZURANOLONECGS8216THIOPENTAL[3H]AZIETOMIDATEMETHAQUALONESANDARACOPIMARIC ACIDFLURAZEPAM HYDROCHLORIDEDARIGABATSECOBARBITAL SODIUMETIFOXINEISOPIMARIC ACIDBRETAZENILISOGUVACINEGLUTETHIMIDE
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |