Protein detail

GBRA1

Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) (GABAAR subunit alpha-1)

Entry name GBRA1	UniProt ID P14867	EVMP score 0.50
Frequency 1	Transmembrane count 4	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) (GABAAR subunit alpha-1)

Protein Class

Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

254..274; Helical; 280..301; Helical; 312..333; Helical; 422..441; Helical

Transmembrane Count

Ensembl

ENSG00000022355

Entrez Gene Symbol

GABRA1

Gene Synonym

EJM5

Gene Description

Gamma-aminobutyric acid type A receptor subunit alpha1

Chromosome

Position

161847063-161899981

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAdrenal cortex cells

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No
receptor	receptor	CellCellInteractions	No	Yes	No	No	No
gaba	receptor	HGNC	No	Yes	No	No	No
receptor	receptor	HGNC	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCD19	Q8TAB3	GBRA1	P14867	Yes	Yes	No	SIGNOR	SIGNOR:29360992

Protein Complex Composition

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GABA-A (a1-b1-g2) receptor	GABRA1 GABRB1 GABRG2	P14867 P18505 P18507	2:2:1	SIGNORComplexPortal	intact:EBI-48428573SIGNOR:SIGNOR-C330	35355020 34417930 14755292 29950725
GABA-A receptor (GABRA1GABRB2GABRD)	GABRA1 GABRB2 GABRD	O14764 P14867 P47870	1:2:2	CORUMCellChatDBCellPhoneDBComplexPortal	CellPhoneDB:GABA-A_a1b2d_complexCORUM:7462intact:EBI-48423922	34153311 17159992 34417930 18204487 15115768 14755292 27493204 36804572 19766404
GABA-A receptor (GABRA1GABRB2GABRG2)	GABRA1 GABRB2 GABRG2	P14867 P18507 P47870	2:1:2	CellChatDBCellPhoneDBComplexPortalCORUMCompleatPDB	PDB:6X3XPDB:6X3UPDB:8sgoPDB:8si9PDB:9drxPDB:6x3xPDB:6x3wPDB:9CRSPDB:6d6uCORUM:5809PDB:7t0wPDB:8vqyPDB:6X3VPDB:6X40PDB:8sidPDB:8SI9PDB:6x40PDB:9crsPDB:6d6tPDB:6X3TPDB:6x3uintact:EBI-9008426PDB:6x3zPDB:6X3SPDB:8SGOPDB:6x3sPDB:8DD3CellPhoneDB:GABA-A_a1b2g2S_complexPDB:8dd2PDB:7t0zPDB:6x3vPDB:6X3WPDB:8DD2PDB:6D6UPDB:6D6TCompleat:HC3449PDB:8vrnPDB:6X3ZPDB:8dd3PDB:6x3t	11992121 35933426 37607940 34417930 14755292 18790874 37892178 27493204 32879488 39843743
GABA-A receptoralpha1-beta1-beta2-gamma2	GABRA1 GABRB1 GABRB2 GABRG2	P14867 P18505 P18507 P47870	1:2:1:1	ComplexPortalPDB	PDB:9cxdPDB:9CXDintact:EBI-61254168	35933426 37607940 34417930 14755292 37892178 32879488 39843743
GABA-A_a1b2_complex	GABRA1 GABRB2	P14867 P47870	1:1	CellPhoneDBCellChatDB	CellPhoneDB:GABA-A_a1b2_complex
	GABRA1	P14867	10	PDB	PDB:6cduPDB:6d1s
	GABRA1 TMEM35A	P14867 Q53FP2	2:2	PDB	PDB:9h9e

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryR Sequencing	1	37704453

Sequence, Structure & Domains

Sequences

Length

456

Mass

51,802

Sequence

MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ

3D Structural Models

Turn

50..52; 59..63; 82..85; 171..174; 191..193; 337..339

Helix

39..49; 100..102; 117..119; 202..204; 251..256; 258..270; 271..273; 279..301; 312..336; 419..444

Beta Strand

66..81; 86..98; 109..113; 126..128; 131..133; 139..141; 144..149; 152..165; 177..188; 194..200; 205..208; 216..232; 235..248; 302..304; 346..348

3D Structure

Electron microscopy (76); X-ray crystallography (2)

Domain & Motif Annotations

Domain (CC)

The extracellular domain contributes to synaptic contact formation.; DOMAIN: The GABA-binding pockets are located at the interface between neighboring alpha and beta subunits.; DOMAIN: GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Protein Families

Ligand-gated ion channel (TC 1.A.9) family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
GABRA1 sub-subfamily

Sequence Similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.

Clinical Relevance

Disease Involvement

Disease variantEpilepsyFDA approved drug targets

Related Diseases

Acute respiratory distress syndrome Anxiety disorder Chronic insomnia Chronic pain Corneal disease Cystitis Depression Epilepsy/seizure Female pelvic pain Headache Indeterminate colitis Insomnia Liver vascular disorder Malaria Mental/behavioural/neurodevelopmental disorder Postoperative inflammation Status epilepticus Tonus and reflex abnormality Tremor-related disorder

Biomarker

Approved; Discontinued in Phase 3; Phase 2; Discontinued in Phase 1; Investigative; Phase 3

Drug Targets

FDA approved drug targets

Drugs

ZK-93423 QUAZEPAM ZOPICLONE ALPRAZOLAM TRIAZOLAM ESTAZOLAM HALAZEPAM MEPHOBARBITAL METHOXYFLURANE BARBITURATE L838417 FLUMAZENIL ACAMPROSATE CALCIUM GABOXADOL ISONIPECOTIC ACID PROGABIDE BUTALBITAL ISOFLURANE GANAXOLONE ESZOPICLONE BUTOBARBITAL CLORAZEPATE TALBUTAL NULL ZK93426 TEMAZEPAM CHLORDIAZEPOXIDE HYDROCHLORIDE MIDAZOLAM HYDROCHLORIDE BUTABARBITAL LORAZEPAM TPA023 TBPS [3H]CGS8216 PENTOBARBITAL SODIUM FLUDIAZEPAM PHENOBARBITAL DESFLURANE ETHCHLORVYNOL METHOHEXITAL SODIUM BREXANOLONE ZALEPLON DIAZEPAM CINOLAZEPAM HEXOBARBITAL NITRAZEPAM METHAQUALONE HYDROCHLORIDE OCINAPLON DIMDAZENIL [3H]GABAZINE PRAZEPAM BUTABARBITAL SODIUM CHLORDIAZEPOXIDE THIAMYLAL SODIUM PAGOCLONE CENOBAMATE PADSEVONIL PROPOFOL THIAMYLAL MEPROBAMATE FLURAZEPAM &ALPHA 3IA CLONAZEPAM CIPEPOFOL TRICLOFOS SODIUM CLOBAZAM CLOTIAZEPAM METHYPRYLON ETOMIDATE ZN2+BICUCULLINE PRIMIDONE METHOHEXITAL SECOBARBITAL TETRAHYDRODEOXYCORTICOSTERONE INDIPLON CLORAZEPATE DIPOTASSIUM ZOLPIDEM TARTRATE [18F]FLUOROETHYLFLUMAZENIL HALOTHANE TETRAZEPAM TOPIRAMATE SEVOFLURANE THIOPENTAL SODIUM BARBITAL PIPERIDINE-4-SULPHONIC ACID MRK016 AMOBARBITAL FLUNITRAZEPAM METHARBITAL CHEMBL:CHEMBL2170369 ADINAZOLAM THIOCOLCHICOSIDE OXAZEPAM [3H]MUSCIMOL &ALPHA 5IA RO15-4513 CHLORMETHIAZOLE REMIMAZOLAM PICROTOXIN LOREDIPLON RO4938581 RO19-4603 [35S]TBPS ENFLURANE REMIMAZOLAM BESYLATE ZK93423 DEHYDRATED ALCOHOL BROMAZEPAM ADIPIPLON DMCM TP003 RESEQUINIL ABP-700 ZURANOLONE CGS8216 THIOPENTAL [3H]AZIETOMIDATE METHAQUALONE SANDARACOPIMARIC ACID FLURAZEPAM HYDROCHLORIDE DARIGABAT SECOBARBITAL SODIUM ETIFOXINE ISOPIMARIC ACID BRETAZENIL ISOGUVACINE GLUTETHIMIDE

Antibody

CAB022502 HPA029363 HPA055746