Protein detail
PLAK
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Entry name PLAK | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Ensembl
Entrez Gene Symbol
Gene Synonym
CTNNGDP3DPIIIPDGBPGPKGB
Gene Description
Junction plakoglobin
Chromosome
17
Position
41754604-41786931
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificparathyroid glandCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificmammillary bodyBlood Cell Specificmyeloid DCBlood Lineage Specificdendritic cellsSecretome LocationSecreted to bloodSecretome FunctionImmunity
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Cellular Component
- GO:0001533 cornified envelope
- GO:0005576 extracellular region
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005882 intermediate filament
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0005915 zonula adherens
- GO:0005925 focal adhesion
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0014704 intercalated disc
- GO:0016342 catenin complex
- GO:0030018 Z disc
- GO:0030057 desmosome
- GO:0032993 protein-DNA complex
- GO:0035580 specific granule lumen
- GO:0070062 extracellular exosome
- GO:0071665 gamma-catenin-TCF7L2 complex
- GO:1904813 ficolin-1-rich granule lumen
Molecular Function
- GO:0003713 transcription coactivator activity
- GO:0005198 structural molecule activity
- GO:0005515 protein binding
- GO:0016922 nuclear receptor binding
- GO:0019903 protein phosphatase binding
- GO:0042803 protein homodimerization activity
- GO:0045294 alpha-catenin binding
- GO:0045296 cadherin binding
- GO:0050839 cell adhesion molecule binding
- GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
- GO:0106006 cytoskeletal protein-membrane anchor activity
Biological Process
KEGG
- hsa04382 Cornified envelope formation
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05202 Transcriptional misregulation in cancer
- KEGG:hsa05221 Acute myeloid leukemia
- KEGG:hsa05226 Gastric cancer
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
Reactome
- R-hsa-418990 adherens junctions interactions
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-9833576 cdh11 homotypic and heterotypic interactions
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-6809371 formation of the cornified envelope
- R-hsa-168249 innate immune system
- R-hsa-6805567 keratinization
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9762292 regulation of cdh11 function
- R-hsa-9764302 regulation of cdh19 expression and function
- R-hsa-9764561 regulation of cdh1 function
- R-hsa-9768727 regulation of cdh1 posttranslational processing and trafficking to plasma membrane
- R-hsa-9764260 regulation of expression and function of type ii classical cadherins
- R-hsa-9759476 regulation of homotypic cell cell adhesion
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013407 rhoh gtpase cycle
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-194138 signaling by vegf
- R-hsa-5218920 vegfr2 mediated vascular permeability
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| JUP | FER | P16591 | Y | 550 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:14517306KEA:14517306ProtMapper:14517306 |
| JUP | FYN | P06241 | Y | 550 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:14517306KEA:14517306ProtMapper:14517306 |
| JUP | FYN | P06241 | Y | 133 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper | KEA:14517306 |
| JUP | SRC | P12931 | Y | 644 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:8081883SIGNOR:14517306KEA:14517306ProtMapper:23911551ProtMapper:14517306 |
| JUP | EGFR | P00533 | Y | 20 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15951569 |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adherens_junction | adherens_junction | OmniPath | No | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FYN | P06241 | PLAK | P14923 | Yes | Yes | Yes | WangPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:14517306HPRD:14517306KEA:14517306ProtMapper:14517306 |
| FER | P16591 | PLAK | P14923 | Yes | Yes | Yes | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:14517306HPRD:14517306KEA:14517306ProtMapper:14517306 |
| CTNA3 | Q9UI47 | PLAK | P14923 | Yes | Yes | No | HuRISIGNOR | SIGNOR:21598020 |
| SRC | P12931 | PLAK | P14923 | Yes | Yes | No | WangSparser_ProtMapperPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:8081883KEA:14517306SIGNOR:14517306HPRD:14517306ProtMapper:23911551ProtMapper:14517306 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| JUPNXT1RANRANBP1RANBP2RANBP3RANGAP1RCC1UBCVRK1VRK3XPO1ZDHHC7 | O14980P0CG48P14923P18754P43487P46060P49792P62826Q8IV63Q99986Q9H6Z4Q9NXF8Q9UKK6 | 1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6428 | ||
| DSPJUPKRT1 | P04264P14923P15924 | 0:0:0 | hu.MAP2 | |||
| DSPJUP | P14923P15924 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Mass spectrometry | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
745
Mass
81,745
Sequence
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDMDGDYPIDTYSDGLRPPYPTADHMLA
3D Structural Models
Turn
398..401; 419..421; 430..433; 478..480; 624..626
Helix
127..131; 133..142; 144..151; 156..169; 173..180; 183..193; 199..212; 216..224; 227..233; 234..236; 240..256; 260..266; 269..272; 274..278; 282..296; 300..308; 311..321; 325..338; 344..350; 353..358; 359..362; 366..380; 390..397; 405..418; 423..429; 434..445; 449..462; 469..477; 481..487; 488..490; 495..508; 512..514; 515..520; 523..543; 556..570; 574..582; 586..592; 598..611; 615..623; 627..633; 639..651; 662..667
Beta Strand
464..466
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Repeat
132..171; ARM 1; 172..215; ARM 2; 216..255; ARM 3; 258..297; ARM 4; 298..341; ARM 5; 342..381; ARM 6; 383..420; ARM 7; 423..464; ARM 8; 470..510; ARM 9; 512..551; ARM 10; 574..613; ARM 11; 615..661; ARM 12
Domain (CC)
The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region.
Region
132..297; Interaction with DSC1 and DSG1; 574..661; Interaction with DSC1
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.
Clinical Relevance
Disease Involvement
Cancer-related genesCardiomyopathyDisease variantPalmoplantar keratoderma
Drugs
Interaction Protein
ENSG00000044115ENSG00000096696ENSG00000103126ENSG00000134982ENSG00000146648ENSG00000170558ENSG00000178585
Interaction Count
7
Interaction Dataset
intact_biogrid