Protein detail

GLNA

Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)

Entry name GLNA	UniProt ID P15104	EVMP score 0.38
Frequency 4	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)

Protein Class

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
ENZYME proteins:Ligase
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Ensembl

ENSG00000135821

Entrez Gene Symbol

GLUL

Gene Synonym

GLNS

Gene Description

Glutamate-ammonia ligase

Chromosome

Position

182378098-182392206

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificretinaCell SpecificPeritubular myoid cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
ENZYME proteins:Ligase
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

9 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AGL DNM1L GLUL HIPK1 HSPD1 UBC	O00429 P0CG48 P10809 P15104 P35573 Q86Z02	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4361
GLUL HIPK1 HIPK3 PIAS1 PIAS2 PIAS3 PIAS4 SNIP1 SREBF2 SUMO1 SUMO2 UBE2I ZCCHC7 ZMIZ2	O75925 O75928 P15104 P61956 P63165 P63279 Q12772 Q86Z02 Q8N2W9 Q8N3Z6 Q8NF64 Q8TAD8 Q9H422 Q9Y6X2	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4579
AKR1C3 ATIC ERCC3 GLUL ISYNA1 OAT PGM1 PPA2 RRM1 RRM2 RRM2B UBC VAMP1	P04181 P0CG48 P15104 P19447 P23763 P23921 P31350 P31939 P36871 P42330 Q7LG56 Q9H2U2 Q9NPH2	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5985
ACSF2 ALAS1 GLUL HEXB HSPD1 SLC25A36	P07686 P10809 P13196 P15104 Q96CM8 Q96CQ1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9440
AGL GLUL HIPK1 HSPD1 PPIE UBC	P0CG48 P10809 P15104 P35573 Q86Z02 Q9UNP9	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9469
AGL GLUL HIPK1 HSPD1 PPIL1 UBC	P0CG48 P10809 P15104 P35573 Q86Z02 Q9Y3C6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5433
AGL GLUL HIPK1 HIPK3 PPIL1 UBC	P0CG48 P15104 P35573 Q86Z02 Q9H422 Q9Y3C6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8401
GLUL	P15104	5	PDB	PDB:2ojwPDB:9otoPDB:7evtPDB:9otmPDB:9otqPDB:8dnuPDB:2qc8PDB:9otnPDB:9otp
ACY1 GCK GLUL HSD17B14 ITPA NEDD8 NIT1 PARK7 PUDP	P15104 P35557 Q03154 Q08623 Q15843 Q86X76 Q99497 Q9BPX1 Q9BY32	0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass Spectrometry	1	38113368

Sequence, Structure & Domains

Sequences

Length

373

Mass

42,064

Sequence

MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN

3D Structural Models

Turn

64..68; 88..90; 167..169; 264..266; 290..295

Helix

5..8; 11..18; 54..56; 72..74; 114..123; 124..127; 173..186; 213..232; 259..262; 267..278; 281..287; 296..298; 327..332; 348..359

Beta Strand

26..33; 35..38; 40..49; 60..63; 69..71; 76..86; 95..102; 106..108; 130..140; 144..146; 158..160; 190..195; 201..210; 235..237; 240..243; 245..247; 251..257; 308..311; 314..316; 321..325; 337..339; 365..367

3D Structure

Electron microscopy (6); X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

24..106; GS beta-grasp; 113..373; GS catalytic

Region

2..25; Required for glutamine-induced ubiquitination by CRL4(CRBN) and proteasomal degradation

Protein Families

Glutamine synthetase family

Sequence Similarities

Belongs to the glutamine synthetase family.

Clinical Relevance

Disease Involvement

Disease variantEpilepsyIntellectual disability

Related Diseases

Parkinsonism

Biomarker

Discontinued in Phase 2

Drugs

BEGACESTAT E-2212 COMBRETASTATIN A4 RG-4733 TREBANANIB SEMAGACESTAT MK-0752 NIROGACESTAT E2012 GSI-136 -CHF 5074.00 AVAGACESTAT TARENFLURBIL

Antibody

HPA007316 HPA007571 CAB008636

Interaction Protein

ENSG00000169045

Interaction Count

Interaction Dataset

biogrid_opencell