Protein detail
GLNA
Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)
Entry name GLNA | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- ENZYME proteins:Ligase
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Ensembl
Entrez Gene Symbol
Gene Synonym
GLNS
Gene Description
Glutamate-ammonia ligase
Chromosome
1
Position
182378098-182392206
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificretinaCell SpecificPeritubular myoid cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- ENZYME proteins:Ligase
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component (9)
Molecular Function (6)
Biological Process (3)
KEGG (9)
- hsa00220 Arginine biosynthesis
- KEGG:hsa00250 Alanine, aspartate and glutamate metabolism
- KEGG:hsa00630 Glyoxylate and dicarboxylate metabolism
- KEGG:hsa00910 Nitrogen metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa01230 Biosynthesis of amino acids
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04724 Glutamatergic synapse
- KEGG:hsa04727 GABAergic synapse
Reactome (4)
Mediation Categories (3)
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence17
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (9)
9 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Mass Spectrometry | 1 | 38113368 |
Sequence, Structure & Domains
Sequences
Length
373
Mass
42,064
Sequence
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
3D Structural Models
Turn
64..68; 88..90; 167..169; 264..266; 290..295
Helix
5..8; 11..18; 54..56; 72..74; 114..123; 124..127; 173..186; 213..232; 259..262; 267..278; 281..287; 296..298; 327..332; 348..359
Beta Strand
26..33; 35..38; 40..49; 60..63; 69..71; 76..86; 95..102; 106..108; 130..140; 144..146; 158..160; 190..195; 201..210; 235..237; 240..243; 245..247; 251..257; 308..311; 314..316; 321..325; 337..339; 365..367
3D Structure
Electron microscopy (6); X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
24..106; GS beta-grasp; 113..373; GS catalytic
Region
2..25; Required for glutamine-induced ubiquitination by CRL4(CRBN) and proteasomal degradation
Protein Families
Glutamine synthetase family
Sequence Similarities
Belongs to the glutamine synthetase family.
Clinical Relevance
Disease Involvement (3)
Disease variantEpilepsyIntellectual disability
Related Diseases (3)
Biomarker
Discontinued in Phase 2
Drugs (13)
Interaction Protein
ENSG00000169045
Interaction Count
1
Interaction Dataset
biogrid_opencell
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No related sentences available |
| 35119778 | Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. | No related sentences available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |
| 39223661 | Proteomic profile of extracellular vesicles from plasma and CSF of multiple sclerosis patients reveals disease activity-associated EAAT2. | No related sentences available |