Protein detail

AMPN

Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)

Protein symbol AMPN	UniProt ID P15144	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersEnzymesMetabolic proteinsPlasma proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)

Protein Class

CD markersEnzymesMetabolic proteinsPlasma proteinsPredicted membrane proteins

Protein Function

Peptidases:Metallopeptidases
Enzymes
CD markers
ENZYME proteins:Hydrolases

Transmembrane

9..32; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000166825

Entrez Gene Symbol

ANPEP

Gene Synonym

AP-NCD13gp150hAPNLAP1p150PEPN

Gene Description

Alanyl aminopeptidase, membrane

Chromosome

Position

89784895-89815401

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAdrenal cortex cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor

Function & Pathway

Protein Function

Peptidases:Metallopeptidases
Enzymes
CD markers
ENZYME proteins:Hydrolases

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M69 Pid reelin pathway
M13 Pid erbb4 pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

38 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AGT ANPEP	P01019 P15144	1:1	PDB	PDB:4fys
ANPEP	P15144	4	PDB	PDB:5lhdPDB:9caoPDB:9cam
ANPEP SFN	P15144 P31947	2:1	PDB	PDB:7aewPDB:6xwd

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Small R sequencing (Illumi HiSeq 2000 (Solexa)Mass spectrometry	16	37786918 39873726 34817906 32795414 38731868 28986585 30608700 33709510 38321535 41201090 30760538 32089743 40311616 39835386 40091455 33709510

Sequence, Structure & Domains

Sequences

Length

967

Mass

109,540

Sequence

MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK

3D Structural Models

Turn

157..160; 213..216; 311..314; 371..373; 396..398; 556..559; 579..582; 737..741; 851..853; 891..894; 925..928

Helix

70..72; 217..219; 277..279; 306..310; 315..331; 364..367; 376..394; 404..407; 408..425; 427..429; 431..434; 435..438; 440..447; 459..461; 465..470; 474..491; 493..507; 514..527; 536..544; 610..612; 624..626; 636..649; 650..652; 655..670; 676..681; 682..688; 692..709; 715..736; 747..762; 766..781; 790..792; 793..803; 806..817; 822..832; 838..848; 856..858; 859..868; 872..882; 884..890; 898..906; 912..924; 931..933; 934..965

Beta Strand

73..75; 78..91; 102..115; 118..123; 126..129; 135..142; 150..156; 161..168; 175..185; 188..200; 203..211; 231..240; 243..249; 251..253; 256..258; 261..269; 282..285; 288..293; 299..304; 338..348; 350..354; 359..363; 399..403; 510..512; 550..555; 560..565; 586..588; 590..592; 600..602; 604..608; 620..623; 631..634; 742..746

3D Structure

Electron microscopy (3); X-ray crystallography (12)

Domain & Motif Annotations

Compositional Bias

41..62; Low complexity

Region

33..68; Cytosolic Ser/Thr-rich junction; 40..62; Disordered; 69..967; Metalloprotease; 288..295; Necessary and sufficient to mediate interaction with HCoV-229E

Protein Families

Peptidase M1 family

Sequence Similarities

Belongs to the peptidase M1 family.

Clinical Relevance

Related Diseases

Psoriasis

Biomarker

Phase 2

Drugs

ANGIOGENESIS INHIBITOR NULL COMPOUND I3 [PMID: 23428964][3H]LY341495 JFD00064 COMPOUND 4 [PMID: 21105727]COMPOUND 34 [PMID: 20409708]COMPOUND 48 [PMID: 22364337]PTBE CBIPES GAMMA-INTERFERON ZINC CHLORIDE MNI-137 GSK1331258 [3H]JNJ-40068782 BTB07018 COMPOUND 1A [PMID: 25692029](1S,3R)-ACPD DCG-IV 4-MPPTS LY379268 TRIBUTYRIN THIIC JNJ-46281222 PL37 THERAPEUTIC HORMONE CEPHALOSPORIN ANTIBIOTIC MITOFLAXONE 3-MPPTS JNJ-42153605 L-CCG-I CURCUMIN CYPPTS RECOMBINANT TRANSFORMING GROWTH FACTOR COMPOUND 3 [PMID: 21105727]BETULINIC ACID PROTEASE INHIBITOR [3H]2,2,2-TEMPS BIPHENYLINDANONE A CYCLOSPORINE MNI-136 IL-13 NALOXONE HYDROCHLORIDE COMPOUND 2 [PMID: 21105727]JNJ-40068782 4-APPES COLCHICINE AZD8529 GENTAMICIN DICLOFENAC SODIUM TOSEDOSTAT CISPLATIN OPIORPHIN EGLUMEGAD (2R,3R)-APDC UBENIMEX ZINC SULFATE ANHYDROUS EPOETIN ALFA MNI-135 JNJ-40411813 CEFADROXIL ANHYDROUS CNGRC PEPTIDE-TNF ALPHA CONJUGATE GSK1331268 RO4491533 LY395756 GLUTAMIC ACID (+)-MCPG HALOPERIDOL DECANOATE LY341495

Antibody

CAB002417 HPA004625