Protein detail

INGR1

Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)

Entry name INGR1	UniProt ID P15260	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)

Protein Class (6)

CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (5)

Predicted intracellular proteins
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

246..266; Helical

Transmembrane Count

Ensembl

ENSG00000027697

Entrez Gene Symbol

IFNGR1

Gene Synonym (2)

CD119IFNGR

Gene Description

Interferon gamma receptor 1

Chromosome

Position

137197483-137219449

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificbone marrowCell SpecificBergmann gliaBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function (5)

Predicted intracellular proteins
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

KEGG (18)

Page 1 of 2

Reactome (9)

Canonical Pathways

M30 Pid hdac classii pathway

Mediation Categories (2)

Clinical-translation mediationImmune mediation

Relations & Evidence74

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IFNGR1	JAK1	P23458	Y	457	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapper	SIGNOR:7615558 KEA:8156998 ProtMapper:7615558 phosphoELM:8156998
IFNGR1	JAK2	O60674	Y	457	phosphorylation	KEA	KEA:8156998

Ligand-Receptor Signaling (59)

59 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cytokine_type_2	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No

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Regulatory Interaction Network (8)

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IFNG	P01579	INGR1	P15260	Yes	Yes	No	iTALKKEGG-MEDICUSSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrscConnectReactome_SignaLink3HPRDCui2007Wojtowicz2020IntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbMacrophageconnectomeDB2020SPIKE_LCLRdbSPIKE	connectomeDB2020:11250200 HINT:10860730 HINT:7673114 Lit-BM-17:7673114 SignaLink3:7510216 SPIKE_LC:17145710 Baccin2019:11250200 HPRD:10986460 HPRD:12165521 IntAct:11250200 IntAct:7617032 SignaLink3:11250200 connectomeDB2020:12165521 SignaLink3:1396683 SignaLink3:16237089 HINT:30814731 Macrophage:7617032 SPIKE:16110316 InnateDB:7673114 SignaLink3:8631301 SignaLink3:7514165 SignaLink3:20304997 SIGNOR:12438563 Baccin2019:10986460 Lit-BM-17:11250200 Lit-BM-17:7617032 SignaLink3:16467876 SignaLink3:9111318 SignaLink3:18988627 Lit-BM-17:10986460 DIP:10860730 Lit-BM-17:10860730 SIGNOR:23898330 SignaLink3:18591661 SignaLink3:10986460 HINT:10986460 SignaLink3:12438563 SignaLink3:15143187 SignaLink3:29145629 SignaLink3:12165521 connectomeDB2020:10811850 SignaLink3:23331499 HPRD:11250200 SignaLink3:7673114 SIGNOR:10986460 SignaLink3:7617032 SPIKE_LC:16110316 CellTalkDB:10811850 LRdb:10811850 HINT:33961781 InnateDB:10986460 LRdb:10986460 SignaLink3:12915721 connectomeDB2020:10986460 SignaLink3:8550631 BioGRID:10986460 LRdb:12165521 SignaLink3:15530433 SignaLink3:7615558 Baccin2019:12165521 HPMR:10811850 HINT:11250200 HINT:7617032 Baccin2019:10811850 LRdb:11250200 DIP:7617032 HPMR:12438563
INGR1	P15260	JAK1	P23458	Yes	Yes	No	MacrophageKEGG-MEDICUSSIGNORReactome_SignaLink3HPRDCui2007HINTSignaLink3InnateDBWang	SIGNOR:15864272 InnateDB:12133952 Macrophage:7615558 Macrophage:8550631 SIGNOR:17063185 SignaLink3:12040185 SignaLink3:12438563 SignaLink3:29145629 HINT:12133952 SignaLink3:23331499 SignaLink3:16467876 HPRD:12133952 Macrophage:8232552 SignaLink3:24243840 HINT:33961781 Macrophage:8649432
JAK1	P23458	INGR1	P15260	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAInnateDBLi2012HPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperMacrophageSparser_ProtMapper	InnateDB:12133952 Macrophage:7615558 Macrophage:8550631 SIGNOR:19041276 KEA:8156998 HINT:12133952 Macrophage:7796299 SIGNOR:7615558 phosphoELM:8156998 HPRD:12133952 Macrophage:8232552 ProtMapper:7615558 HINT:33961781 Macrophage:8649432
JAK2	O60674	INGR1	P15260	Yes	Yes	No	PhosphoPointSIGNORHPRDCui2007PhosphoSite_KEAKEAWang	SIGNOR:23898330 KEA:8156998 HPRD:7499845 HPRD:11438544
INGR1	P15260	JAK2	O60674	Yes	Yes	No	KEGG-MEDICUSSIGNORHPRDCui2007SignaLink3Wang	SIGNOR:23898330 SIGNOR:15864272 SIGNOR:17063185 HPRD:11438544 SignaLink3:12040185 SignaLink3:23331499 HPRD:7499845
SOCS1	O15524	INGR1	P15260	Yes	Yes	Yes	HPRDWangSIGNORSignaLink3	SignaLink3:15522878 SignaLink3:18988627 SignaLink3:18708154 HPRD:15522878 SignaLink3:23331499 SIGNOR:18708154
INAR1	P17181	INGR1	P15260	Yes	Yes	No	SignaLink3	SignaLink3:18929502 SignaLink3:23331499
GSK3B	P49841	INGR1	P15260	Yes	Yes	No	SIGNOR	SIGNOR:28883123

Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IFNGR2/INFGR1	IFNGR1 IFNGR2	P15260 P38484	0:0	Guide2PharmaCellChatDBSIGNORICELLNETCellinkerSPIKE	SIGNOR:SIGNOR-C142	15032600
Type_II_IFNR	IFNG IFNGR1	P01579 P15260	2:3	CellPhoneDBPDB	CellPhoneDB:Type_II_IFNRPDB:1fyhPDB:1fg9
	IFNG IFNGR1 IFNGR2	P01579 P15260 P38484	2:2:2	PDB	PDB:6e3lPDB:6e3k
	IFNGR1 MAD2L2 SHLD2	P15260 Q86V20 Q9UI95	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	6	27863537 34817906 28986585 27894104 30646616 38321535

Sequence, Structure & Domains13

Sequences

Length

489

Mass

54,405

Sequence

MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P15260-1; Sequence=Displayed; Name=2; IsoId=P15260-2; Sequence=VSP_055589, VSP_055590, VSP_055591

Alternative Sequence

1..28; MALLFLLPLVMQGVSRAEMGTADLGPSS -> MLLKSPENSLLQFQFKYG (in isoform 2); 184..196; QYKILTQKEDDCD -> KRSCAFSLFSFFI (in isoform 2); 197..489; Missing (in isoform 2)

3D Structural Models

Turn

192..194; 222..224

Helix

88..90; 121..124; 149..151

Beta Strand

33..38; 40..42; 45..49; 58..65; 69..71; 74..86; 98..106; 131..136; 138..146; 168..178; 181..191; 197..205; 212..221; 234..237

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

335..348; Basic and acidic residues; 349..360; Polar residues; 379..391; Low complexity; 401..412; Basic and acidic residues; 415..429; Low complexity

Region

329..437; Disordered

Protein Families

Type II cytokine receptor family

Sequence Similarities

Belongs to the type II cytokine receptor family.

Clinical Relevance7

Disease Involvement (2)

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (2)

INTERFERON GAMMA-1B INDOLE-3-CARBINOL

Antibody (6)

CAB025889 HPA029213 HPA063871 CAB080493 CAB080494 CAB080495

Interaction Protein (2)

ENSG00000111537ENSG00000140688

Interaction Count

Interaction Dataset (2)

intact_biogrid_bioplexintact_biogrid

Supporting Publications1

PMID	Title	Abstract
12519789	Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.	An alpha 4-integrin may direct B cell-derived exosomes to follicular dendritic cells, which were described previously as potential target cells. Most exosome-associated proteins, including MHC class II and tetraspanins, were insoluble in 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid (CHAPS)-containing buffers.