Protein detail
ANPRA
Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)
Entry name ANPRA | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)
Protein Function
- Kinases:RGC receptor guanylate cyclase kinases
- ENZYME proteins:Lyases
- Enzymes
- Transporters:Accessory Factors Involved in Transport
- FDA approved drug targets:Small molecule drugs
Transmembrane
474..494; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Kinases:RGC receptor guanylate cyclase kinases
- ENZYME proteins:Lyases
- Enzymes
- Transporters:Accessory Factors Involved in Transport
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0001653 peptide receptor activity
- GO:0004383 guanylate cyclase activity
- GO:0004672 protein kinase activity
- GO:0005524 ATP binding
- GO:0005525 GTP binding
- GO:0008528 G protein-coupled peptide receptor activity
- GO:0016941 natriuretic peptide receptor activity
- GO:0017046 peptide hormone binding
- GO:0042562 hormone binding
Biological Process
KEGG
- hsa00230 Purine metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04714 Thermogenesis
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04923 Regulation of lipolysis in adipocytes
- KEGG:hsa04924 Renin secretion
- KEGG:hsa04925 Aldosterone synthesis and secretion
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NPR1 | PRKACA | P17612 | S | 529 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper | KEA:9528788 |
| NPR1 | PRKX | P51817 | S | 529 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| NPR1 | PRKY | O43930 | S | 529 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| NPR1 | PRKACB | P22694 | S | 538 | phosphorylation | KEA | KEA:17570479 |
| NPR1 | PRKCB | P05771 | S | 534 | phosphorylation | KEA | KEA:17570479 |
| NPR1 | PRKCB | P05771 | T | 532 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ANF | P01160 | ANPRA | P16066 | Yes | Yes | No | iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBReactome_LRdbGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb | Cellinker:12547834HINT:1660465scConnect:8700153LRdb:12547834Cellinker:8700153connectomeDB2020:8700153LRdb:8700153Cellinker:15911069Cellinker:12488235HPMR:15911069LRdb:15911069connectomeDB2020:15911069HPRD:12547834SIGNOR:15911069connectomeDB2020:12547834HINT:12547834CellChatDB:29934640Guide2Pharma:8700153SPIKE_LC:16713569 |
| ANPRA | P16066 | A1AG1 | P02763 | Yes | Yes | No | SIGNOR | SIGNOR:23363605 |
| ANPRA | P16066 | NAR1 | P52961 | Yes | No | Yes | SIGNOR | SIGNOR:33024932 |
| ANPRA | P16066 | A1AG2 | P19652 | Yes | Yes | No | SIGNOR | SIGNOR:23363605 |
| KAPCA | P17612 | ANPRA | P16066 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointProtMapperKEAKinexus_KEAPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:20977274PhosphoSite:9528788KEA:9528788PhosphoSite:28416574 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ANPR-A receptor complex | NPR1 | P16066 | 2 | ComplexPortalPDB | PDB:9bcoPDB:9bcsPDB:8tgaPDB:9bcvPDB:9bcnPDB:9bclintact:EBI-10093340PDB:9bcp | 14755292108945511511795214600147 |
| CHST12GSPT1NPR1OGA | O60502P15170P16066Q9NRB3 | 0:0:0:0 | hu.MAP | |||
| NPPANPR1 | P01160P16066 | 1:2 | PDB | PDB:8tg9PDB:9bcq |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
1,061
Mass
118,919
Sequence
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
3D Structural Models
Turn
94..96; 149..151; 265..267; 382..386; 415..417; 428..431
Helix
52..67; 97..108; 119..132; 145..147; 163..176; 195..210; 225..238; 248..261; 278..280; 299..305; 306..308; 320..337; 345..347; 348..369; 377..381; 846..848; 855..862; 885..888; 894..912; 940..956; 997..1008; 1018..1027
Beta Strand
34..41; 72..75; 77..83; 90..92; 111..114; 136..139; 155..157; 180..188; 190..192; 214..221; 240..245; 269..273; 295..297; 309..314; 387..391; 394..398; 402..404; 408..413; 420..427; 432..435; 444..447; 850..853; 870..881; 918..923; 926..935; 972..985; 987..989; 991..996; 1013..1016; 1030..1038; 1047..1054
3D Structure
Electron microscopy (9)
Domain & Motif Annotations
Domain (FT)
528..805; Protein kinase; 876..1006; Guanylate cyclase
Protein Families
Adenylyl cyclase class-4/guanylyl cyclase family
Sequence Similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Clinical Relevance
Biomarker
Phase 2; Approved