Protein detail
LYAM3
P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
Protein symbol LYAM3 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
Protein Class
Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- CD markers
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
772..795; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD62CD62PGMP140GRMPPADGEMPSEL
Gene Description
Selectin P
Chromosome
1
Position
169588849-169630193
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell Specificnon-classical monocyteSecretome LocationSecreted to bloodSecretome FunctionNo annotated function
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- CD markers
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
- GO:0001530 lipopolysaccharide binding
- GO:0005178 integrin binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008201 heparin binding
- GO:0033691 sialic acid binding
- GO:0042806 fucose binding
- GO:0043208 glycosphingolipid binding
- GO:0048306 calcium-dependent protein binding
- GO:0070492 oligosaccharide binding
Biological Process
KEGG
Reactome
Canonical Pathways
- M88 Pid cd8 tcr pathway
- M54 Pid il12 2pathway
- M272 Pid cd8 tcr downstream pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| other_receptor_family | receptor | HPMR | No | Yes | No | Yes | No |
Page 1 of 7Next
Regulatory Interaction Network
2 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
830
Mass
90,820
Sequence
MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP
3D Structural Models
Turn
104..106; 112..114
Helix
53..63; 73..82; 167..170
Beta Strand
43..46; 64..67; 90..97; 100..103; 131..134; 139..141; 145..148; 154..160; 171..176; 178..185; 189..191
3D Structure
NMR spectroscopy (1); X-ray crystallography (4)
Domain & Motif Annotations
Motif
818..821; Endocytosis signal
Domain (CC)
The C-type lectin domain is required for binding to integrins (PubMed:37184585). Binding to soluble integrins alpha-V/beta-3 (ITGAV:ITGB3) and alpha-IIb/beta3 (ITGA2B:ITGB) is cation-dependent in order of preference of 1 mM Mn(2+) > Mg(2+) > Ca(2+) (PubMed:37184585). Binds to the allosteric site (site 2) of integrins and activates them (PubMed:37184585). The interaction with integrins may mediate cell-cell interactions and cell adhesion (PubMed:37184585).
Domain (FT)
58..158; C-type lectin; 159..195; EGF-like; 198..259; Sushi 1; 260..321; Sushi 2; 322..383; Sushi 3; 384..445; Sushi 4; 446..507; Sushi 5; 508..569; Sushi 6; 570..631; Sushi 7; 640..701; Sushi 8; 702..763; Sushi 9
Region
821..830; Interaction with SNX17
Protein Families
Selectin/LECAM family
Sequence Similarities
Belongs to the selectin/LECAM family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Related Diseases
Biomarker
Discontinued in Phase 1; Phase 1; Phase 3; Approved; Phase 2; Phase 2/3; Phase 4; Discontinued in Phase 2
Drug Targets
FDA approved drug targets